Alejandro Llorente, Ph.D.

Postdoctoral fellow at Columbia University in the laboratory of Dr. Oliver Clarke. Protein design & structural biology

[Alejandro Llorente, Ph.D. @LlorenteJandro]

@labordabio Very cool job Carlos.
Podemos ponernos en contacto?
I would love to send you a message 😊

[Rowan Reads @RowanReads]

https://t.co/wQUm8mfQu5

[Vincent, MD @vincent_toxins]

What if designing a protein felt less like writing code and more like sculpting something with your hands?

A new bioRxiv preprint introduces ProteinSketch, a VR environment where researchers can physically sketch protein backbones in 3D, shape the volume they want a protein to occupy, and let a diffusion model turn those gestures into molecular structures.

Put on a headset, use both hands to draw a topology or define a curved 3D envelope, and RFdiffusion continuously refines that spatial idea into candidate proteins.

This sounds almost like a futuristic interface demo, but the deeper problem is real: generative protein models are becoming extremely capable, while communicating high-level spatial intent to them remains surprisingly difficult.

A sequence prompt is easy to type. “Build me a protein that bends around this molecular surface, enters this gap, and presents a binding interface here” is much harder.
ProteinSketch makes geometry itself part of the conversation.

The researchers used volumetric constraints to generate unusual anisometric protein shapes and confirmed shape fidelity by cryo-EM. They also used the same framework for functional binder design and to extend existing minibinders toward molecular surfaces that conventional design approaches struggled to reach.

What I like about this direction is that it changes the interface to generative biology. We have spent enormous effort teaching models the geometry of proteins. The next challenge may be giving humans a more natural way to express the geometry they actually want.

Maybe the future protein-design language will not be text at all. It may be shape, motion and space.

Preprint : https://t.co/iGy1Dtn8tB

[Anindyadeep @anindyadeeps]

In last one day, I predicted more than 1200+ structures, feels like Ksh Aetchum, gotta catch em all!

[Alkatranck @alkatranck]

@MasterChef_es Este video es probablemente lo más asqueroso que he visto en todas las ediciones de #masterchef. Enhorabuena por promover y hacer apología del bullying.

[Alejandro Llorente, Ph.D. @LlorenteJandro]

9/9 If you want to learn more about the how we modified NIS selectivity, the lessons that we learn from its Cryo-EM structure, as well as read our proof-of-principle showing that this proposed therapy can work:
Check out our manuscript! 👇
https://t.co/DY43yAzDcm

[Alejandro Llorente, Ph.D. @LlorenteJandro]

1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵 #Science #proteinengineering https://t.co/DY43yAzDcm.

[Alejandro Llorente, Ph.D. @LlorenteJandro]

8/9 ✅My work details how we successfully engineered a version of human NIS that transport as much ReO��⁻ as WT-NIS, and it doesn’t transport I⁻. We created a molecular tool that could be used to kill cancer cells while leaving healthy thyroid tissue untouched!

[Innerworld App @innerworldapp]

Heal and grow with a community that gets it. 💜

[Innerworld App @innerworldapp]

📣 Last call! 📣 Today is the final day to enter our *final* ticket giveaway for Jewel's show in Austin, TX on Oct. 1!

Follow us and visit the link below to enter. Winner will be picked TOMORROW, September 27th 🎟️✨
https://t.co/QOCfx6S9Oc

[Alejandro Llorente, Ph.D. @LlorenteJandro]

Is there anyone with experience in importing particles from CryoSparc back to RELION who would be willing to teach me how to do it? 🙏🏻

[Innerworld App @innerworldapp]

Innerworld 2.0 is live! This update brings a sleek, user-friendly interface that makes it easier to find events and connect with our vibrant community. Plus, we've optimized the mobile version for a seamless experience on the go. Dive into a smoother, more intuitive Innerworld!

[Innerworld App @innerworldapp]

First Jewel Ticket Giveaway is live!

Our CSO Jewel has begun her summer tour! Join the fun—visit the link below to win two tickets to see Jewel live in San Diego at the Rady Shell on July 23rd!

🗓️ Promotional Period: Now - 7/18
🎟️ Winner Picked: 7/19

https://t.co/M3vQWYB8EE

[Óscar Puente @oscar_puente_]

¿No es maravilloso?