Lydilue @lydilue.bsky.social

Labour Law, Mama

#TeamKinderschutz
#TeamInfektionsschutz
#CleanAir
#Maskebleibtauf
#luftfilterfürkitasundschulenjetzt

[Hiroshi Yasuda (保田浩志) @Yash25571056]

From a study of 349 children and adolescents in Mexico,
"The prevalence of long COVID was 11.8%.
For “persistence”, the most frequent symptoms were cough (50%) and rhinorrhea (15.4%); for “post-COVID conditions”, the most common symptoms were myalgia (33.3%), asthenia and irritability (26.7% each), and constipation (20%)..
the associated factors for individuals aged over 8 years were a history of reinfection (OR 9.7) and BMI at the time of the survey (1.1), while for those aged under 8 years, the associated factor was male sex (4.7)."

Be aware of reinfection, kids.

'SARS-CoV-2 reinfection: a possible contributing factor to long COVID in children and adolescents'
https://t.co/yGYlT1WrnH

[Keith @keetmuise]

Typical June in Canada sees an estimated 150-250 cases of flu. This June in Canada is seeing an estimated 98,500-168,100 estimated Covid cases in one week. This is considered a "low" period for Covid. This much sickness year round is not acceptable or sustainable.

[Ruth Ann Crystal, MD @CatchTheBaby]

173 kids w/ MIS-C after COVID vs. 14,000 controls.
Followed 4.5 years.

MIS-C kids had:
14x risk of CV disease
8.9x risk of hypertension
9.5x risk of GI problems
3.5x risk of respiratory
2x risk of Neurologic disorders.

Long term effects in kids are real. https://t.co/ptQr8eL6hF

[Ronen Steinke @RonenSteinke]

Frauenfeindliche Straftaten haben um 46,8 Prozent zugenommen. Warum interessiert sich Dobrindt so wenig dafür? Mein Kommentar: https://t.co/bj7JDgtF8B

[Danielle Beckman @DaniBeckman]

The Office for National Statistics estimates that around 110,000 children in England & Scotland are living with Long Covid.

Friends, if you live in the UK, please help us by contacting your elected representatives. Letter template below! #LongCovidKids
https://t.co/wFAzv7qUty

[Zdenek Vrozina @ZdenekVrozina]

A new review pulls the neurobiology of Long COVID into a pretty strong map.
Neuroinflammation here is not treated as one isolated process. It’s the place where viral persistence, glia, BBB, blood vessels, mast cells, vagus nerve, metabolism, and unstable brain networks all meet🧵

[Harry Spoelstra @HarrySpoelstra]

Research progress on the association between viruses and cardiac diseases

🚨Your heart’s deadliest serial offender just got named: SarsCoV2

Interesting Chinees review just mapped how six viruses attack the heart.

One stands out!

Not because the authors scream “worst ever,” but because the science does.

→Direct heart-cell invasion + long-term damage + cumulative hits from regular reinfections = a unique threat!

Vaccines help. But the data is sobering.

Let’s break it down virus by virus(review):

1. SARSCoV2:
- Enters cardiomyocytes and pericytes via ACE2 receptor (membrane fusion/endocytosis).
- Direct infection triggers myocarditis, pericarditis, arrhythmias, heart failure (de novo or exacerbation), microclots, thromboembolic events and myocardial infarction,
- Long-term: persistent cardiac inflammation, dysautonomia and long-COVID cardiovascular symptoms,
- Possible viral persistence in tissue,
- Vaccination reduces myocarditis risk/CV complications compared with natural infection,
-Regular reinfections!

2.Influenza (A/B):
- Direct replication in cardiomyocytes, Purkinje cells and endothelial cells (independent of lung titers),
- Causes myocarditis, pericarditis, arrhythmias, heart-failure flares and myocardial infarction via both cytopathic effects and cytokine-driven systemic inflammation/endothelial dysfunction.
- Long-term: myocardial fibrosis and remodelling,
- Vaccines lower infection-related cardiovascular complications,

3. HIV:
- No productive cardiomyocyte infection,
- Indirect damage from chronic immune activation, endothelial dysfunction, metabolic changes and antiretroviral toxicity,
- Drives cardiomyopathy (myocarditis in advanced cases), heart failure, myocardial infarction and stroke,
- Long-term: premature cardiovascular aging, fibrosis and remodelling even on suppressive therapy,

4. CVB3 (Coxsackievirus B3):
- Enters via CAR receptor,
- Direct cytopathic necrosis, oedema and impaired contractility in cardiomyocytes,
- Rapid progression to myocarditis, dilated cardiomyopathy, arrhythmias (QTc prolongation) and heart failure,
- Chronic inflammatory cardiomyopathy is a hallmark sequela,

5. Human cytomegalovirus(HCMV):
- Lifelong latency with reactivation (especially in immunocompromised),
- Induces myocarditis, heart failure, transplant vasculopathy and atherosclerosis through sustained inflammation and vascular injury,
- Long-term myocardial remodelling,

6. Arthropod-borne viruses(Arboviruses = DENV, CHIKV, ZIKV):
- Direct cardiac invasion (some models) plus immune-mediated injury,
- Associated with myocarditis, arrhythmias, heart failure, shock and (CHIKV) dilated cardiomyopathy or long-term ischemic heart disease/cerebrovascular risk.

‼️So, this minireview examines six cardiotropic viruses side-by-side, yet SARS-CoV-2 receives the most space because of its proven direct cardiomyocyte invasion, explosive multi-pathway damage, and documented long-term cardiac persistence, risks that broader population data show accumulate relentlessly with every regular reinfection, creating an immediate and chronic cardiovascular burden on a global scale that no other virus in this review matches.
→Your heart’s deadliest serial offender just got named: SarsCoV2!
#PREVENTION #COVIDHeart #RepeatInfectionKills #AvoidSars2 #AvoidReinfections #YouOnlyHaveOneHeart
https://t.co/BPKRV7nwbA

[Ryan Hisner @LongDesertTrain]

Another fantastic preprint on BA.3.2's propensity for children, this time from @yunlong_cao & co.
They not only confirm the findings of David Ho's lab (that kids have ~0 antibody response to BA.3.2) but dig into the details of exactly why kids are so vulnerable to BA.3.2.

1/4

[Scott Squires @scottsquires.bsky.social @scott_squires]

@SethAbramson We already ARE in a pandemic. Covid is still here. It will kill 150,000 this year. There are 30-40 million with long covid. Long covid is now the #1 chronic illness in children. 5.8 million children 1 in 4 marines has long covid. EVERYONE is at risk regardless of age & health.

[Conor Browne @brownecfm]

1. Remember that any attempt to paint Long Covid as psychogenic in nature deliberately and completely incorrectly biologically decouples SARS-CoV-2 infection from Long Covid. In essence, this rhetoric shifts the causative factor for LC from the virus to the patient's mind.

[Eric Topol @EricTopol]

Big progress vs cancer, folks.
The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO

[Bettina Grande @GrandeBettina]

Statt medizinischer Unterstützung Münchhausen by Proxy Verdacht:

Das Leid und Unrecht,
das Eltern und ihren an #MECFS #PEM erkrankten Kindern durch Unkenntnis, Psychologisierung
und sogar Inobhutnahme widerfährt, ist ungeheuerlich.

@BMG_Bund, @ninawarken:

Aufklärung jetzt!

[Corinna Geiger @DrCorinnaGeiger]

Long COVID & ME/CFS teilen oft denselben autonomen Phänotyp – 92% reduzierter zerebrovaskulärer Blutfluss, 95% autonome Dysfunktion. Das sind KEINE psychischen Erkrankungen. Das sind messbare, neurologische Befunde. #MECFS #LongCovid #POTS
https://t.co/RlT0h7P4us

[Lydilue @lydilue.bsky.social @lydilue]

@Chrissip81

[Lydilue @lydilue.bsky.social @lydilue]

@Chrissip81 Empfehle Wickelfisch zu verwenden. Schweizer Patent, für die Rheinschwimmer in Basel entwickelt.

[Carmen Scheibenbogen @C_Scheibenbogen]

Ich freue mich sehr über die Kooperation mit Prof Akiko Iwasaki @VirusesImmunity bei dieser wichtigen Studie.
Sie ist ein Meilenstein für unser Verständnis der Rolle von Autoantikörpern bei Long COVID.
Link zum Artikel und der Thread von Akiko Iwasaki.
https://t.co/N2WmjN9vVd

[Ralf Wittenbrink @RWittenbrink]

Systematische Untererfassung: Belastung durch Long Covid doppelt so hoch ist wie bisher angenommen

Forschungsergebnisse des Mass General Brigham zeigen, dass die tatsächliche Belastung durch Long COVID durch die derzeitigen Überwachungsmethoden deutlich unterschätzt wird und …

[Prof. dr. Vivienne Matthies-Boon @V_MatthiesBoon]

@NobleRingleader Wir, eine Gruppe interdisziplinärer Forscher, reichen Montag einen wissenschaftlichen Artikel über die ethische Katastrophe des KWG im Zusammenhang mit MECFS/Long Covid ein.... 🤞

[Ralf Wittenbrink @RWittenbrink]

Gesamtbilirubin-Werten (TBIL). Im Vergleich zu den negativen Kontrollen waren die ALT-, AST- und GGT-Werte bei COVID-19-positiven Patienten signifikant erhöht, während die ALP- und TBIL-Werte keine signifikanten Veränderungen zeigten.
Dies deutet darauf hin, dass

[Zdenek Vrozina @ZdenekVrozina]

This paper is interesting because it identifies a concrete neurochemical signal in the CNS that connects long COVID/PASC, PEM, fatigue, and reduced physical endurance - lower activity of the central noradrenergic pathway in cerebrospinal fluid🧵