Updates from the WHO Classification of Breast Tumors, 6th Edition (not published yet)
The WHO 5th edition recommended that encapsulated papillary carcinoma (EPC) with high nuclear grade, increased mitotic activity, and/or a triple-negative or HER2-positive phenotype be graded, staged, and managed as invasive disease
In the 6th edition, the WHO now recognizes the existence of rare forms of EPC with high-grade features or ER negativity that may still be categorized as EPC
Such tumors may be encountered on core biopsy; classifying them as invasive could lead to inadvertent neoadjuvant therapy
The vast majority of EPCs should be low- to intermediate-nuclear grade and ER-positive
Dr. Tan #USCAP #pathology #PathX #PathTwitter
5 Things Every Pathology Resident Should Know About Invasive Breast Carcinoma NST
3. E-cadherin isn’t enough
E-cadherin is one of the most useful immunostains when distinguishing invasive breast carcinoma NST from invasive lobular carcinoma—but it should never be interpreted in isolation.
A panel is often more informative:
- NST: membranous E-cadherin, β-catenin, and p120 (Case A 👇)
- Lobular carcinoma: loss of E-cadherin and β-catenin, cytoplasmic p120 (Case B 👇)
Be aware of aberrant staining patterns. As always, morphology comes first—immunohistochemistry should support, not replace, the diagnosis.
#PathX #PathTwitter #breastpath
Breast - Granular cell tumor
They are inhibin positive, maybe a better stain that CD68
They are S100 and SOX10 positive CK and ER negative
Pitfall ⚠️
- They can look compressed/elongated (pic 3) instead of epithelioid like cells
- They can look like muscle (pic 4)
Dr. Cimino-Mathews #BreastPath #PathX #Pathtwitter #USCAP #pathology
هل يمكن تسريع إعداد مراجعة أدبية منهجية؟ 📚
جرّب https://t.co/xb90pG5RfT واختر Gatsbi Reviewer، أدخل موضوعك وأنشئ بروتوكول المراجعة، ثم احصل على مسودة تتضمن: العنوان، الملخص، المنهجية، النتائج، المناقشة والمراجع، مع إمكانية التصدير إلى Word وLaTeX وMarkdown. مناسبة كنقطة بداية
PhD Students - Here is an example of a good discussion section.
A good discussion section should answer 6 questions.
1. What is different in your findings compared to previous research?
2. What is similar in your findings compared to previous research?
3. How different sections of your results section correlate?
4. What are the implications of your findings for practitioners?
5. What are the implications of your findings for researchers?
6. What are the limitations or threats to the validity of your findings?
الزملاء في الدراسات العليا ||
أربع أدوات أساسية للباحثين العلميين: تعزيز الكفاءة في البحث والتحليل
في ظل التحول الرقمي للبحث العلمي، أصبحت بعض الأدوات الذكية ضرورية لكل باحث يسعى إلى رفع جودة عمله واختصار الوقت والجهد.
يقدم هذا الفيديو نظرة تحليلية على أبرز أربع أدوات حديثة تساهم في تطوير ممارسات البحث الأكاديمي:
❶ https://t.co/7Wl4kRycKv
❷ https://t.co/EofKZAlYBl
❸ https://t.co/FyPAkBxfcX
❹ https://t.co/F6YWmzO24m
هذه الأدوات لا تقتصر على تسهيل عمليات البحث فحسب، بل تُمكّن الباحث من الوصول إلى رؤى أعمق وتحليلات أكثر دقة، مما يعزز من جودة الرسائل العلمية والأوراق البحثية.
#الدراسات_العليا #البحث_العلمي #أدوات_
↴✿ فيديو توضيحي 🎥 :
Another outstanding collaboration between @IntSocUropath and @GU_Path_Society! We hope these practical recommendations help support standardized diagnosis and reporting in daily practice. #gupath
🔗 Read the full review: https://t.co/KXaKXumjT3
🔬 Low Grade Mucinous Appendiceal Neoplasm (LAMN)
The diagnosis often rests less on cytologic atypia & more on architectural features:
✅ Loss of lamina propria
✅ Fibrotic/hyalinized wall
✅ Pushing growth
Contributed by: @ardenne_m#Pathology#PathX#GIPath
MMR or MSI? One of the most common areas of confusion in oncology and pathology.
A simple way to remember it:
🧬 MMR = Machinery (IHC)
🔬 MSI = Mistakes (PCR/NGS)
✅ IHC checks whether the DNA mismatch repair proteins (MLH1, PMS2, MSH2, MSH6) are present.
✅ PCR/NGS measures the genomic consequence—microsatellite instability.
High-yield takeaway:
• dMMR ≈ MSI-H
• pMMR ≈ MSS
• MSI-L is uncommon and is generally managed similarly to MSS for most clinical decisions, including immunotherapy selection in colorectal cancer.
Save this visual for exam revision and daily oncology practice.
#MedTwitter #Oncology #Pathology #MolecularPathology #ColorectalCancer #Immunotherapy #MMR #MSI #PrecisionOncology #CancerEducation #FOAMed #MedEd #MedicalOncology #DrNB #CancerConceptsExplained
أدوات الذكاء الاصطناعي لمراجعة #الأدبيات_العلمية (AI Tools for Literature Review) لم تعد مراجعة الأدبيات العلمية (#Literature_Review) مهمة تقليدية تعتمد فقط على الجهد اليدوي، بل أصبحت مجالًا تتكامل فيه الخبرة البحثية مع أدوات الذكاء الاصطناعي لتعزيز الجودة، الدقة، والسرعة.👇👇
CLL involving the prostate it is. 😊
A diffuse, monomorphic lymphoid infiltrate with preservation of benign prostatic glands may raise suspicion for lymphoma.
Chronic prostatitis is usually more mixed and predominantly periglandular.
Ref: Differential Diagnoses in Surgical Pathology: Genitourinary System.
#DxMindMap #ProstatePath #GUPath #PathTwitter @JHUpath