Bruce J MacLachlan

Structural Immunologist at Cardiff University. Big fan of HLA presentation and recognition by innate and adaptive receptors, cycling and cats.

[Gallimore Godkin Lab @GallimoreGodkin]

We are excited to share new research from our group! A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. @CellReports
https://t.co/jHsRp9CLO1

[Bruce J MacLachlan @MacLachlanBJ]

Finally, some images of the crystals that help to further our understanding of CD4+ T cell / HLA-II biology. 8/8

[Bruce J MacLachlan @MacLachlanBJ]

Our study on CD4+ T cell epitopes of SARS-CoV-2 is published online in @CellReports. We define model antigens presented by HLA-DR1 and assess the impact of Spike mutations on T cell recognition 1/8. @GallimoreGodkin @CUSystemsImmu https://t.co/8LwBhst9qQ

[Bruce J MacLachlan @MacLachlanBJ]

Massive thanks to the team, Chen, @GallimoreGodkin & collaborators @LongLabGroup. @WelshGovernment/@LlywodraethCym & @wellcometrust for funding this work, @DiamondLightSou (mx beamlines, i04 & i04-1) & @ResearchWales for continued funding. 7/8

[Bruce J MacLachlan @MacLachlanBJ]

Extremely excited to start today as a recipient of a Health and Care Research Wales - Health Research Fellowship! Many thanks to the support of @ResearchWales in helping to ask questions about how the immune system recognises cancer.

[Health and Care Research Wales @ResearchWales]

We are proud to announce the recipients of our 2021-22 funding call awards.

Read more about the people and projects we invested in:
https://t.co/Ae7ubPMdUB

[@[email protected] @NadiaHalidi]

A tribute to Dr. Ling Felce.
I just read about the horrific Oxford accident: a cyclist trapped beneath a lorry and died at the scene. The very same place I hated and dreaded. Then, I found out that the person who died, was my former labmate and friend Ling! I'm shocked and 1/7

[Immunotherapy Advances Journal @IMTadvances]

New review | Seven mysteries of #LAG3: A multi-faceted #immune receptor of increasing complexity 🔍

🔗https://t.co/4vqlaQptqJ
✍ Stephanie Burnell @Capitani_L @MacLachlanBJ et al. @GallimoreGodkin

[Bruce J MacLachlan @MacLachlanBJ]

@WaelAwadMoh @arc_gov_au @Jamie_Rossjohn @RossjohnLab @MonashBDI @Monash_FMNHS Amazing, congratulations Wael!

[EF Pro Cycling @EFprocycling]

Nothing beats a good “morning ride” 😅 #thealttour

[💮Nicole La Gruta @NicoleLaGruta1]

Very pleased to share our study, first author @PiroozZareie, with @RossjohnLab @GrasLab, showing that canonical TCR-pMHC docking is critical for localization of coreceptor-associated Lck to the CD3 complex for signaling @ScienceMagazine @MonashBDI https://t.co/CepHGw7rAt

[Rossjohn lab @RossjohnLab]

New NK cell KIR paper from the lab, in collaboration with Andrew Brooks and Julian Vivian. @MonashBDI @MoradiShoeib
https://t.co/o4FszV0gvA

[Sandra Lopez-Leon MD PhD @sandralopezleon]

🦠 El ciclo replicativo del #coronavirus
https://t.co/AAlKAlj2jw

[Rossjohn lab @RossjohnLab]

In collaboration with Andrew Brooks' lab and Julian Vivian's lab, latest paper on Natural Killer cell receptor (KIR3DL1) recognition of HLA-I.
https://t.co/Mok2SIghwn @ImagingCoE @TheDohertyInst @MonashBDI

[Michael Crowther @Michael44364760]

Here's a new review, co-written by me and Prof Andy Sewell, on MR1-restricted T-cells in different disease states, published in Current Opinion in Immunology. Link to the free paper (for 50 days) here! https://t.co/UfEswEG1D2

[Novo Amor @iamnovoamor]

the most wholesome way to end the year. Thanks for using my song @dog_rates ♥️