Bushra Khan

Making some changes

[Jason Hickel @jasonhickel]

Bombing Iran in the middle of negotiations, while starving Cuba, while genociding Palestinians, while threatening to invade Greenland… the US and Israel are the single greatest threat to humanity and it’s not even close. We are all forced to live in the nightmare they create.

[Brandon Stanton @humansofny]

“I remember taking my final exam, getting stuck on an answer, and thinking: ‘Who cares, I’m about to die.’ I knew something was very wrong. Medical school is always tiring, but this was a different kind of tired. I was getting by on multiple cups of coffee, multiple energy drinks. Large lumps had begun to appear in my neck. After the exam I stumbled down the hall to the ER and the doctors told me that my organs were failing. It took eleven weeks to make a diagnosis: a rare disease called Castleman’s. But there was no cure. A priest read me my last rites. I said goodbye to my family and prepared to die. But a last-minute dose of chemotherapy saved my life. Over the next year I relapsed three times. Each one almost killed me. The last was the worst: I spent a month in the ICU, and it took seven different chemotherapies to bring me back. By then I’d reached the maximum dose of chemo a human can tolerate. The doctors told me I was out of options, and the next relapse would certainly kill me. I only had one hope. A tiny hope, but a hope. I had to cure the disease myself. It takes a billion dollars and ten years to create a new drug; I didn’t have the money or time. My only chance was to discover an existing drug that would work. I made spreadsheets of every similar disease and every drug used to treat it. I wrote over 2000 emails to every doctor who’d published a paper on Castleman’s. I started studying samples of my own blood, but I ran out of time. Another relapse put me back in the ICU; from my hospital bed I asked the doctor to cut out one of my lymph nodes. I took it to the lab and discovered a particular protein called mTOR that was sending my immune system into overdrive. And that’s when I knew. I knew from my research that a drug called Sirolimus inhibits mTOR. My doctor was hesitant to prescribe it; there was no research to support my theory. But he took a chance, and within days my symptoms began to disappear. I still take the pill every day, eleven years later. I was able to marry my wife and have two beautiful kids. And through my work I’ve been able to save thousands of lives, by repurposing fourteen different drugs to treat rare diseases.”
---------------
Epilogue:
In 2022, @DavidFajgenbaum co-founded Every Cure, a nonprofit organization on a mission to save and improve lives by repurposing existing medicines to treat devastating diseases. While many drugs could be repurposed to treat many more diseases than they were intended to treat, there are no incentives in our current system to unlock these additional uses. Every Cure utilizes an AI platform to identify the most promising new uses for existing medicines for further laboratory research and clinical trials and works to get these treatments to all of the patients who can benefit. They have already launched 8 drug repurposing programs, including injection of the numbing medicine lidocaine for breast cancer and the vitamin derivative leucovorin for a subgroup of children with autism spectrum disorder who have anti-folate receptor antibodies.

[Benny James @Beno_ldn]

You know you're getting old when you're entering your D.O.B on a website & you need to fuckin spin it like you're on the Wheel Of Fortune.

[Words @wordsporn]

Sonder

[Classy Arabic Poetry @ClassyArabic]

Working hard won't
make you more money;
you won't lose any
if your take your time.

No sadness
or joy endures,
no ease lasts forever
nor pain.

If your heart is filled
with acceptance,
you and the king of the world
are the same.

— Imām al-Shāfiʿī

[Ahmed Gaza @ahmedabd_gaza]

They didn’t find empty land
They emptied the land.

[Peter Daou @peterdaou]

Please tell me, what kind of person starves children to death? What kind of person shoots starving children?

[Mr. Nobody @MmisterNobody]

Who else feels like something huge is about to happen?

[Yash Tiwari @dryashtiwari]

In the parallel universe 🥰

[🍂 @Lovandfear]

“The hypocrisy of being human; the constant tug between solitude and company, the desire to love so desperately and simultaneously be detached from it all, of wanting everything and wanting nothing”.

— Unknown

[🍃 @ladybuginit]

Twitter do your thing.
I'm looking for a small furnished apartment for 3 people in (lhr) areas linked with raiwand road.

[Tahir Imran Mian ✈ @TahirImran]

People in Islamabad are making shit load of money manipulating the embassy appointment system.
German embassy appointment starts around Rs.40 thousand.
US embassy appointments are being sold at around half a million rupees depending on dates.

[Aqsa. @ItsmeAqsaa]

Everytime i came across a dua it feels like Allah really wanted me to make it because most of the time its about my situation or for future. "Reminder helps the believer" because what you are seeking is seeking you, what you wanted rn or in future is already being told you to+

[Bushra Khan @made_of_atom]

@PicturesFoIder Ink heart, coherence

[Sarah @itsSarahAman]

My “Half of 2023” wisdom:

- Life can be the deepest pit of despair one day, and then make you feel like you won the lottery the next. Wait for the few good days, and know that the bad ones won’t last. “No feeling is final.” Say it to yourself until you believe it. Live by it.