Sean Maden

Sean is a senior-level bioinformatician (he/him; views mine) #analytics #programming #python #bash #shiny #workflows #etl #genomics #rnaseq #epigeneti#verified

[Sean Maden @MadenSean]

Big ups #megwhite and #jackwhite of #thewhitestripes for induction into The Rock & Roll Hall of Fame. I have fond memories listening to their records in HS and college, binge-watching Under Blackpool Lights. Well earned! #rockandrollhalloffame #thewhitestripesmusic #bluesrock

[Sean Maden @MadenSean]

@homsiT Just wondering how do I properly read a proper read?

[Sean Maden @MadenSean]

@pkoo562 @zrcjessica From the retrospective, was it wise to base the experiment around deep ensembles initially? It makes intuitive sense, I just wonder if ensemble parsimony is showing its age. Perhaps student models and ensemble models converge in performance but for entirely different reasons.

[Sean Maden @MadenSean]

@YudiXie235 Excited to learn about your journey and progress. I am interested in the origins of Bayesian modeling and its divergence from frequentist approaches, where the dichotomy makes sense. The latter part of your post seems too behavioral to be impartial.

[Sean Maden @MadenSean]

@selcukorkmaz In addition to differences to be aware of when reporting either SE or SD, work that uses one measure or the other can suggest important details about model assumptions, experiment conditions, etc. For example, if SE is used but not SD, it could be there are Bayesian alternatives.

[Sean Maden @MadenSean]

A helpful perspective on the societal value of empirical pursuit. STEM disciplines and public funded research needs more support than ever, especially going in to this next administration.

[David A. Markowitz @DavidAMarkowitz]

The $3B Human Genome Project was started under a Republican administration and later acknowledged by the Obama admin to have returned $141 to the economy for every $1 spent. Science has a higher ROI than any other category of government spending.

[Sean Maden @MadenSean]

@OdedRechavi Publish negative results however possible, whether a lab protocol, preprint, or manuscript. Further, why was it negative, could it be bias or latent factors, and does it warrant a new letter, method, or review? Do others in your field agree or have similar unreported findings?

[Sean Maden @MadenSean]

Into the Abyss: How a Deadly Plane Crash Changed the Lives of a Pilot, a Politician, a Criminal and a Cop - Carol Shaben

[Sean Maden @MadenSean]

Outliers - Malcom Gladwell

[Sean Maden @MadenSean]

Demon Copperhead - Barbara Kingsolver

[Sean Maden @MadenSean]

The Tiger: A True Story of Vengeance and Survival - John Vaillant

[Sean Maden @MadenSean]

@MishaTeplitskiy This is a norm that needs to change. Replication of science is science, and further presents its own set of challenges over original or entirely novel work. Groundbreaking insight has its place, but we should not neglect teaching/training/collaboration opportunities so much.

[Sean Maden @MadenSean]

@johnrushx Appreciated . Please no smoking

[Sean Maden @MadenSean]

The more you know! One of the best mathematics channels on YouTube uses GitHub.

[Tom Dörr @tom_doerr]

3Blue1Brown's animation code is public

[Dr. Catharine Young @DrCatharineY]

Scary

Credit: @twisteddoodles

[Bobby Weir @BobWeir]

Well, OK, I guess it all depends on your worldview; you can see your place in the world as something to defend from those who might want to take some or all of it from you—or you can see it as a grand adventure, a place to make dreams come to fruition for yourself & others.
(1/3)

[Sean Maden @MadenSean]

Absurdly anachronistic aestheticism.

[Megan Gozzard @PhDood1es]

What geneticists fear the most: The Cambridge Plot.

[Sean Maden @MadenSean]

Remember to follow me here >

[Sean Maden @MadenSean]

Job search insights: #employers should recommend and re-evaluate good #applicants for alt open positions, not simply serve decline emails. #Recruitment cost can be drastic, rerouting benefits applicants & employers, and it would improve org perception. https://t.co/at8AAYpzl2