Ma. Ignacia Allende

MD, Masters student & research assistant @georgeinstitute @UNSW | Main research on Stroke, diet and sex differences

[Eric Topol @EricTopol]

Western diets are pro-inflammatory and a recipe for chronic disease risk
https://t.co/SqI614ULT6
@NatureMedicine

[Ma. Ignacia Allende @mallende1996]

Throwback to when I got my Clinical Research Fellowship Diploma #research #postgrad

[Ma. Ignacia Allende @mallende1996]

@CDawgVA You look like the guy who plays Wonderwall at parties to get girls 😂

[The Lancet @TheLancet]

Current projections estimate 153 million people will be living with dementia by 2050.

Nearly half of dementia cases could be prevented or delayed by tackling 14 risk factors starting in childhood, suggests new report from a standing Lancet Commission: https://t.co/ZFRBBbIfdZ

[Eric Topol @EricTopol]

Much of dementia—perhaps half—could be prevented or substantially delayed with attention to 14 modifiable risk factors
@TheLancet Commission 2024 report https://t.co/wsphtAfk77
New inclusion of cholesterol and vision loss as risk factors

[World Stroke Academy @WorldStrokeEd]

#MondayTip
☝️Cervical artery #dissection contributes to 2% of all ischemic strokes but up to 25% of ischemic stroke in adults <50 years of age

💎Predictors of ischemic stroke after #CAD

From: https://t.co/8s04NGeAtw
#OpenAccess

[Ma. Ignacia Allende @mallende1996]

My new paper reading implementations strategies to implement the INTERACT3 care bundle in Latin America is out! https://t.co/p7LQRT9YU4

[Dr. Sean Mullen @drseanmullen]

If I could choose just four studies out of the over 500 I’ve reviewed to convince you to take precautions from SARS-CoV-2, the following would be on my list:

1. The Lancet just published a compelling study of >16 million people demonstrating the risk of type 2 diabetes after COVID-19 was significantly higher in unvaccinated individuals compared to vaccinated ones. Hospitalized COVID-19 patients faced a dramatically higher risk of developing diabetes, which declined over time but remained elevated. Most importantly, 60% of those diagnosed with type 2 diabetes after COVID-19 continued to have the condition 4 months later (https://t.co/U08gHQoyuJ).

2. A study in The New England Journal of Medicine from February (2024) shows alarming accelerated cognitive decline in all individuals infected with SARS-CoV-2, even after a recovery period (https://t.co/B6gjgSRA8Y).

3. A preprint on macaque monkeys reveals that even mild and asymptomatic cases of COVID-19 can lead to the formation of Lewy bodies post-infection (https://t.co/01pUt1J8Wx). Moreover, a peer-reviewed study on rhesus monkeys showed an equally disturbing increased presence of tau proteins, in all monkeys (https://t.co/K2u4gjIuCJ).

4. The 2007 SARS1 mouse study, which is crucial for understanding the potential severity of coronavirus infections. No mouse survived beyond the 16th serial passage, a phenomenon we refer to as the "rule of 15" or the “passthrough rule.” This shows evidence of the evolutionary process and the dangers of allowing it to spread unabated (https://t.co/H0SC7a5Yqi).

Given the compelling evidence from these studies alone (with intentional omission of the immune dysfunction, elevated cardiac/stroke risk and gut problems), it should be clear as day, that this virus is NOT by any means “mild.” It can do lasting damage on the metabolic system and central nervous system which impairs everyday physical and cognitive functioning. It can cause performance errors and incapacity to work. It’s dangerous and threatens our way of life.

The public has been lied to and cleaning indoor air, masking indoors and vaccinating against SARS-CoV-2 are essential public health measures.

Note that I’ve left out studies showing increased risk rising with repeated infection, and I’ve omitted studies showing the efficacy of precautions… because people don’t take precautions unless they agree that infection poses a serious concern. And until now, we are fighting survival bias and people who think “brain fog” is some kind of rite of passage to immunity.

People don’t understand brain fog from SARS2 is brain damage. People also don’t understand that not being hospitalized isn’t some kind of gold star participation award that keeps you free of lifelong effects from pathogens that can persist in your blood, bone and organs. Until they understand what they’re doing to their bodies and brains, they’ll take zero action. Explain it to them, before it’s too late.

[Stroke AHA/ASA @StrokeAHA_ASA]

🧵Call for Submissions: Go Red for Women® February 2025

Stroke welcomes the submission of manuscripts focusing on the topic of cerebrovascular diseases and women. Basic, clinical, translational and population science topics related to stroke in women will be considered.

[BensenHsu @BensenHsu]

The researchers found that people who received the recombinant shingles vaccine had a significantly lower risk of developing dementia within 6 years of vaccination compared to those who received the live vaccine. Specifically, the recombinant vaccine was associated with a 17% increase in the time lived without a dementia diagnosis, which translates to 164 additional days lived without a dementia diagnosis among those who were affected.

full paper: https://t.co/JOpiMP2AFP

[The Lancet @TheLancet]

Neurological conditions now leading cause of ill health and disability globally, affecting 3.4 billion people worldwide, suggests GBD study in @TheLancetNeuro

On #WorldBrainDay:
➡️ Read the paper: https://t.co/Uzmbm2yNBW
➡️ Explore the infographic: https://t.co/cWebU9tYmL

[The Lancet @TheLancet]

The World Federation of Neurology (@wfneurology) celebrates #WorldBrainDay on July 22 to raise awareness of neurological disorders & promote brain health globally.

This year's focus is brain health & prevention.

Learn more in a letter in @TheLancetNeuro: https://t.co/oUxYyZri9w

[Eric Topol @EricTopol]

A relationship ≠ cause and effect. A major depressive disorder can underly excessive sleep duration.
A side note: many studies have concluded that 7 hours is the optimal sleep duration. For example:
https://t.co/ZG5vxJ3pCu

[Ma. Ignacia Allende @mallende1996]

So proud of my first article as a first author 🙌💗

[The Lancet Diabetes & Endocrinology @TheLancetEndo]

New—Understanding the cause of type 2 #diabetes https://t.co/IeBziX39Ry #overnutrition