ซ่อนเข็มในสำลี

[Shining Science @ShiningScience]

🚨 Massive 44-year study reveals that long-term cannabis use does not accelerate cognitive decline.

It debunks long-held myths about the drug’s impact on brain aging.

For decades, concerns over the long-term cognitive effects of cannabis have fueled public health warnings, yet a comprehensive 44-year study from Denmark is now challenging those assumptions. Researchers tracked more than 5,000 men from early adulthood into their mid-sixties, comparing intelligence scores recorded at age 20 to follow-up assessments at age 64. The results, published in the journal Brain and Behavior, found no evidence that cannabis use accelerates cognitive decline. In a surprising twist, those with a history of use actually showed a marginally smaller decrease in IQ points—approximately 1.3 points less—than their non-using counterparts, effectively questioning the notion that the drug inevitably impairs long-term mental acuity.

While the findings are striking, experts note that lifestyle factors and 'cognitive reserve' may play a significant role in these outcomes. The study revealed that cannabis users in this cohort often possessed higher baseline IQs and education levels, which are known to influence cognitive resilience. Crucially, the researchers discovered that neither the frequency of use nor the age at which an individual started using the substance significantly impacted their intelligence later in life. Although the study was limited to men and relied on self-reported data, it provides some of the most robust longitudinal evidence to date that past cannabis use does not inherently doom the aging brain to a faster decline.

Source: Christensen, T. W., Mortensen, E. L., & Osler, M.. Cannabis use and change in intelligence from age 20 to 64: A 44-year follow-up of 5,162 Danish men. Brain and Behavior.

[İslam Özkan (Yeni hesap) @islamozkannn]

Belgeselci Hamilton Morris ilginç bir adam. Dünyayı dolaşıp adın sanı bilinmeyen, garip halisünasyon yapıcı maddeleri ve özel uyuşturucuları bizzat deneyimleyip bunları kayda alıyor. Yapımcılığını ve yönetmenliğini üslendiği Amerikan belgesel programının adı ''Hamilton’s Pharmacopeia''.

Videodaki deneyimi, Amerika'nın Sonora Çölü'nde yaşayan kurbağalardan çıkarılan zehirle ilgili.. Zehirde, 5-MeO-DMT adlı son derece güçlü bir halüsinasyon bileşeni bulunuyor.

"Dünyadaki en güçlü doğal halüsinasyon maddelerinden biri" olan bu maddenin etkisi inanılmaz derecede güçlü ve kısa sürede benlik tamamen yok olan bir deneyim yaşatıyormuş.

Deneyimleyenler arasında "öldüm", "tanrı ile birleştim", "benliğim tamamen kayboldu" diye tarif edenler de çokmuş.

[Massimo @Rainmaker1973]

Psilocybin made human cells live 50% longer.

A new study has uncovered surprising anti-aging potential in psilocin—the active metabolite produced when the body breaks down psilocybin, the psychoactive compound found in magic mushrooms.

In laboratory experiments, researchers exposed two human cell lines (skin fibroblasts and fetal lung fibroblasts) to a 100 μM concentration of psilocin. The results were striking: lung cells took 57% longer to reach replicative senescence (the point at which cells permanently stop dividing and accumulate damage), while skin fibroblasts extended their replicative lifespan by 51%.

These findings suggest psilocin may slow fundamental cellular aging processes, possibly by lowering oxidative stress, enhancing DNA-repair pathways, supporting mitochondrial health, or dampening chronic inflammation—mechanisms that overlap with those targeted by leading experimental longevity drugs.

The benefits extended beyond cell culture. In aged female mice (19 months old at the start, equivalent to approximately 60–65 human years), a single monthly dose of psilocybin dramatically improved outcomes. After 10 months of treatment, 80% of the psilocybin-treated animals remained alive, compared with only 50% of untreated controls. Treated mice also displayed markedly fewer visible signs of aging, including reduced fur loss and graying.

This research marks the first direct demonstration that psilocybin/psilocin can influence biological aging itself, rather than solely producing psychological effects. The authors emphasize that the study used relatively conservative dosing and are now advocating for follow-up work with higher or more frequent administration, detailed assessments of immune, metabolic, and cognitive function, and investigations into whether the extended lifespan corresponds to genuine improvements in healthspan and quality of life.

["Psilocybin treatment extends cellular lifespan and improves survival of aged mice." npj Aging, 2025]

[Jaylor Rana @UnpaidPhilosphr]

Everyone romanticizes the single life until they're eating alone at 60 with a passport full of stamps and no one to call family. Money loses its thrill, travel becomes routine, and books don't answer back. Marriage or being in a relationship isn't the answer to everything, but neither is solitude. Every life extracts a price, you don't escape it, you only choose how you'll pay.

[Proton Mail @ProtonMail]

Gmail is FREE
TikTok is FREE
Google is FREE
Chrome is FREE
YouTube is FREE
ChatGPT is FREE
Facebook is FREE
Instagram is FREE
WhatsApp is FREE

You pay with your personal data.

[Nick Sortor @nicksortor]

People keep asking me why I, as an American, am concerned about African Muslims invading Spain.

It’s simple: Spain will issue the invaders passports, and the invaders will use those passports to come HERE.

It’s INEVITABLE.

The invasion MUST be repelled.

[Tropah @TropahPalm]

Kick streamer Mexican Andy climbed to the top of the tallest trash mountain in India

The mountain even has its own mini trash rivers with dirty water running through it ☣️😷

[millllllionaire 🦭อยากเป็นแมวน้ำ @MIU_MILL]

เบื่อกราฟฟิกทุกอย่างที่มาจากเอไอมากๆ ทั้ง โพสต์ขายของขายประกัน โพสต์ปกคลิป โพสต์รับสมัครงาน ไหนจะรูปในแอพเดลิเวอรี่อีก คือมันแพทเทิร์นเดียวกันหมด เอียนมากๆ

[0HOUR1 @__0HOUR1_]

Spain has no women refugees. Yes, 30K men will want to have sex with Spanish women.

Enjoy Africa

[Dexerto @Dexerto]

Thai travel YouTuber Hlun Solo has been found dead at age 27 in a hotel room in Tbilisi, Georgia

His family reported him missing after more than two weeks without contact

[Abdul Qadeer @Ju_n0on]

@Dexerto Georgia is the most ra#!st country i’ve ever visited. The Police is corrupt took 50 lari from me literally on Europe square. People are ra#!st give you weird look and don’t help you in navigation or don’t even like to talk to you. Immigration is a nightmare.
I’m sure he’s killed

[มังกรน้ำทะเล @Mangkon_namtale]

[ ลองจินตนาการดู... ถ้าวันนี้คุณตายไป ]

ไม่กี่ชั่วโมงแรก: ครอบครัวจะจมอยู่กับความโศกเศร้า

ผ่านไป 1 วัน: ญาติมิตรจะรู้ข่าว บางคนเสียใจ บางคนแค่ทอดถอนใจ

ผ่านไป 7 วัน: จะมีแสงเทียนและคำไว้อาลัยปรากฏขึ้นในโซเชียล

ผ่านไป 2 สัปดาห์: ทุกอย่างจะกลับสู่ความเงียบสงบ เหลือเพียงคนใกล้ชิดจริงๆ ที่ยังทำใจไม่ได้

ผ่านไป 1 ปี: ชื่อของคุณแทบจะ���ม่ถูกพูดถึงอีกเลย

ผ่านไป 3 ปี: อาจเหลือเพียงพิธีกรรมเล็กๆ ที่บันทึกว่าคุณเคยมีตัวตน

หลายปีผ่านไป: บนป้ายหลุมศพอาจมีดอกไม้บ้าง แต่ส่วนใหญ่จะมีแค่ฝุ่น

สุดท้าย: ทุกคนจะกลับไปใช้ชีวิตปกติ ราวกับว่าคุณไม่เคยมีตัวตนอยู่บนโลกนี้เลย

พราะฉะนั้น... คุณนั่นแหละคือ "เจ้าของโลก" ในนี้วันที่คุณหลับตาลง โลกทั้งใบสำหรับคุณก็แค่ "ปิดเครื่อง" ไปเท่านั้น

คนอื่นรอบตัวก็เป็นแค่ NPC ในเกมชีวิตของคุณ ทุกเรื่องราวที่เจอคือ "ภารกิจชั่วคราว" และทุกความลำบากก็แค่การ "ตีมอนสเตอร์เพื่อเก็บเลเวล"

หัดใจดีกับตัวเองให้มากๆ รักตัวเองให้สุดหัวใจ ใส่ใจกับ "สุขภาพ" และ "อารมณ์" ของตัวให้มาก เรื่องอื่นที่เหลือ มันไม่ได้สำคัญขนาดนั้นหรอก

[Joey Swoll @TheJoeySwoll]

10 signs you're doing well in life:

1. You have a roof over your head.
2. You ate today.
3. You have a good heart.
4. You care for others.
5. You have clean water.
6. Someone loves you.
7. You try to do better.
8. You have clean clothes.
9. You have dreams.
10. You’re breathing.

[ซ่อนเข็มในสำลี @Manhuntalone]

@run817 นักข่าวไปสัมต้องจ่ายเงินนะครับ ถ้าไม่จ่ายไม่ให้สัม บุคคลที่ดึงคนทั้งชาติตกต่ำ ป่านนี้น่าจะอยู่ใยนรกชาใช้กรรม

[Night Sky Today @NightSkyToday]

JUST IN🚨: Cannabis is Officially Off the US Government's most Restricted Drug List.

[Creepy.org @creepydotorg]

Just a friendly reminder that Sarah Connor was thrown into an insane asylum for trying to sabotage AI data centers.

[Polymarket @Polymarket]

JUST IN: Nearly half of U.S. employers have reportedly stopped testing job applicants for marijuana, as companies warn screening is making it harder to recruit workers.

[𝕯𝖆𝖛𝖎𝖉 @DavidSimon13700]

Drug testing for jobs should exclude cannabis. Period

[Democrats Deliver @DemzDeliver]

🚨 Senate Democrats introduce bill to legalize marijuana nationwide.

[STONERS R US 🍃 @_StonersRUs_]

Gangster granny 😎