Manikandan

Nature lover | Science student | Runner | #RNA | Postdoc @embl | PhD @SinghMLab @MBU_IISc @IIScBangalore

[Manikandan @mani_rps]

A part of my PhD Thesis got published today in @NAR_open. A short non-technical thread about the relevance of our study.
https://t.co/71TrjmqDKV

[EMBL @embl]

50 years of structural biology in the French Alps!

🎂 @EMBLGrenoble celebrates its anniversary alongside alumni, partners, and collaborators, reflecting on past and future achievements. Congratulations!

[Manikandan @mani_rps]

@KasitC10 @MolSystBiol @ChristineMoene @molina_lab @EMBLHeidelberg Congrats Kasit! 💐

[Manikandan @mani_rps]

Amazing work - CRISPR-Cas13 systems likely evolved from Type III TA systems!

[Shai Zilberzwige-Tal @zilberzwige]

RNA-guided systems span kingdoms, from bacterial immunity to eukaryotic gene regulation. How did they evolve? We traced the origins of CRISPR-Cas13 and identified its likely ancestor: an RNA-based toxin-antitoxin (TA) system. Here’s what we uncovered:
https://t.co/oTGjiN2V3H
1/8

[Manikandan @mani_rps]

@zilberzwige Amazing work! Congrats 💐

[Shai Zilberzwige-Tal @zilberzwige]

RNA-guided systems span kingdoms, from bacterial immunity to eukaryotic gene regulation. How did they evolve? We traced the origins of CRISPR-Cas13 and identified its likely ancestor: an RNA-based toxin-antitoxin (TA) system. Here’s what we uncovered:
https://t.co/oTGjiN2V3H
1/8

[Molecular Cell @MolecularCell]

Structural basis of 5′ splice site recognition by the minor spliceosome https://t.co/unazhryWaT

[Molecular Cell @MolecularCell]

Online Now: Structural basis of 5′ splice site recognition by the minor spliceosome https://t.co/bwQXctrVdk

[Olivier Duss @OlivierDuss]

First paper of our lab today @Nature by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl

https://t.co/ui1h01VaQW

[nature @Nature]

Nature research paper: Tracking transcription–translation coupling in real time https://t.co/a24Xxcxdo0

[EMBL @embl]

EMBL Group Leader Olivier Duss and his research team discovered how two molecular machines in bacteria work together and watched their interactions as a real-time movie.

Read the full article to discover how they put snapshots in motion:

https://t.co/3n8BjLzC3C

[EMBL @embl]

Meet Romain Linares, cryo-electron microscopy (cryo-EM) expert at EMBL Grenoble.

In this interview, he talks about his role in managing the cryo-EM platform to explore molecules at the atomic level and his passion for stargazing.

https://t.co/mk7odyZHSl

[EMBL @embl]

Congratulations, Olivier Duss, Simone Köhler, and Eva Kowalinski!

The three EMBL Group Leaders have received ERC Consolidator Grants for their innovative research projects aimed at understanding fundamental cellular mechanisms.

Read more here 👉 https://t.co/ierBNdvwSE

[IISc Bangalore @iiscbangalore]

Hearty congratulations to Prof Raghavan Varadarajan on winning the 2024 Tata Transformation Prize🎉

His lab aims to develop a cost-effective vaccine for Respiratory Syncytial Virus (RSV) which affects 30 million people annually.
https://t.co/OkEOw8nLTj

[König Lab @koenig_lab]

📢 Our work on CDS #m6A mediated RNA decay (CMD) is out in @MolecularCell ! Decay relies on ribosome pausing at m6A containing codons. Great collab with the Zarnack lab & colleagues. Check it out here: https://t.co/KSi8SdR91i
Thank you @imbmainz @Uni_WUE @ItsRMaP1 🥳

[Manikandan @mani_rps]

@mbuanand @JCIM_JCTC @KrishnaKanthbio @LindorffLarsen @JeetainMittal @debayanbiophys Congrats @KrishnaKanthbio and @mbuanand !!

[Manikandan @mani_rps]

@3DRNA_CryoEM @TalesRocha15 @febos41 @jmbujnicki @JMolBiol Congrats Nagendar!

[Saikumar @saikumarjj82]

https://t.co/q00CTDjV0H

@ashwinravi99

Pls do spread the words… Govind is missing

[Prof. Nikolai Slavov @slavov_n]

Timescales in Cell Biology

[Manikandan @mani_rps]

@IshikaPramanic2 @WebsterMichael0 @JohnInnesCentre Congrats Ishika👏🏼

[IISc Bangalore @iiscbangalore]

We are deeply saddened by the passing of Ratan Tata, a visionary leader, philanthropist, and former President of IISc's Court.
A condolence meeting was held today at the Institute to pay respects to him.