Manuel Peitsch

Retired CSO, with a passion for #THR and deep knowledge of the field. Opinions continue to be my own.

[Manuel Peitsch @ManuelPeitsch]

@LivePippas …anyhow, happy to help advance THR!

[Manuel Peitsch @ManuelPeitsch]

@LivePippas Nice demonstration of the threshold for https://t.co/JTCJ5TChfH. The study based on two papers from 1996 and 2010.
By a simple use of arithmetics one can see that e-vapor leads to exposure below the no effect level, while cigs is above.

[Manuel Peitsch @ManuelPeitsch]

@LivePippas That law was first formulated about 500 yrs ago, a time when concepts like “atom”, molecules, etc were to appear far in the future. Nevertheless, Paracelsus observed that “sola dosis facit venenum”. What is it that “modern” public health does not get in this universal law?

[Manuel Peitsch @ManuelPeitsch]

@LivePippas @VapingAlliance @RCPhysicians You are spot on! I also analyzed a lot of data, including that generated by our labs, and come to the same conclusion.

[Manuel Peitsch @ManuelPeitsch]

@SimonChapman6 @JonathanFoulds All these phenomena follow the same law. Latency and dose are mostly independent variables.

[Manuel Peitsch @ManuelPeitsch]

@SimonChapman6 @JonathanFoulds He’d say “Sola dosis facit venenum”. As simple as that: 1) test them, 2) evaluate their tox profile, 3) regulate on the basis of scientific facts. Opinions are unimportant, only solid scientific facts rooted in excellent execution with doses relevant to human consumption matter.

[Manuel Peitsch @ManuelPeitsch]

@SimonChapman6 @JonathanFoulds Clearly societal debates are necessary to develop sound policies that maximize the net population benefits of reduced risk products, but they do not override or obscure the results of the scientific facts that flow from the 1st law of toxicology.

[Manuel Peitsch @ManuelPeitsch]

@SimonChapman6 @JonathanFoulds Important to remember that nature’s laws are not up for negotiations. Also worth remembering that the 1st law of Tox doesn’t care about our needs or wants, doesn’t care about our opinions and ideologies, our policies and governments, our funding sources and conflicts of interest.

[Manuel Peitsch @ManuelPeitsch]

@TahirTturk @NTR_Journal Let’s be accurate: the best option for a smoker to reduce the risks associated with smoking is to quit immediately. However, the risks accumulate during past smoking will only decrease following well-known decay curves. Ergo, the best option is to never start!

[Manuel Peitsch @ManuelPeitsch]

@jkelovuori @NTR_Journal Decades of conflating the effects of smoking with nicotine got us here. Using non-scientific and false arguments to achieve an important objective eventually backfires. The goal does not justify the means, ever.

[Jason Sheltzer @JSheltzer]

Fascinating new preprint on bioRxiv tackles a whale of a question:

Whales are huge. So why don’t they get a ton of cancers?

https://t.co/z0KjxPUebi

[Manuel Peitsch @ManuelPeitsch]

@TECCnews @LungAssociation Amazing: the number of lies and scientific errors in this post. Start with solid particles: only in cigarette smoke, not in a e-cig aerosol. We are actually among the very few people who analyzed this in detail. So that is a fact, and please correct your statement.

[Manuel Peitsch @ManuelPeitsch]

@GregTHR @ChaunceyGardner @jgitchell Well, same story as with cigs… combustion vs absence of combustion.

[Manuel Peitsch @ManuelPeitsch]

@ChaunceyGardner @jgitchell We informed a few a couple of years ago and we developed a test “à la cotinine test” with a small company. Also total NNAL can be used instead/in addition to CYMA. It has a longer half life and hence adds confidence.

[Manuel Peitsch @ManuelPeitsch]

@ChaunceyGardner @jgitchell Nicotine exposure combined with the exposure to acrylonitrile (CYMA), a specific cigarette combustion marker, gives a good indication of the source of that nicotine. Nicotine with CYMA in smokers and dual users; nicotine without CYMA in « pure��» e-cig, HTP, Snus or pouch users.

[Manuel Peitsch @ManuelPeitsch]

@ChaunceyGardner @jgitchell Nicotine exposure combined with the exposure to acrylonitrile (CYMA), a specific cigarette combustion marker, gives a good indication of the source of that nicotine. Nicotine with CYMA in smokers and dual users; nicotine without CYMA in « pure » e-cig, HTP, Snus or pouch users.