Marc Landers

Helping people through medical cannabis education. US Navy vet (Ret), medical cannabis patient. Daily research & stories. Free newsletter ↓

[Marc Landers @marclanders]

Cannabis users showed LESS brain aging/decline!

[Marc Landers @marclanders]

@AMartinelliWA I have a dear friend who just had a knee replacement and was in terrible pain for weeks. Opioids didn't help much. I urged her to consult with her doctor about using CBD, but do to stigma, she wouldn't do it. Sad.

[Marc Landers @marclanders]

@070guy Thanks! 😎

[Marc Landers @marclanders]

@monetization_x What days does the payments normally cover? Is it a Tuesday to a Tuesday?

[Marc Landers @marclanders]

"DEA Enforcement, Marijuana Rescheduling, and Hemp Reform. Your Webinar Questions Answered: Part 1"

Wow! Tons of information here!

Here's the table of contents!

https://t.co/gU1I0BYk9l

[Marc Landers @marclanders]

@kellser64 🙏

[Marc Landers @marclanders]

@karatademada Reminds me of the old saying about luck - "The harder I work, the more I seem to have of it."

I got accepted to the new Creator program yesterday. It was one post that did it for me. That one post got 2 million impressions!

I have no idea why that particular post did so.

[Marc Landers @marclanders]

@karatademada Stay safe!

[Marc Landers @marclanders]

I have a dear friend who just had a knee replacement and was in terrible pain for weeks. Opioids didn't help much. I urged her to consult with her doctor about using CBD, but do to stigma, she wouldn't do it. Sad.

[Anthony Martinelli @AMartinelliWA]

A randomized clinical trial published today found that patients given 400 mg of CBD following bilateral knee replacement surgery used fewer opioids and reported less pain than those receiving a placebo. https://t.co/58YFy7Da2P

[Marc Landers @marclanders]

My wish is to have AI design specific health regimes tailored to the individual.

We don't have a health care system, we have a sick care system. We need to transit to tailored systems to prevent diseases and illnesses, rather than the current system - proactive rather than reactive.

[Healthcare AI Guy @HealthcareAIGuy]

AI x bio has had an insane week.

> Radical Numerics: Omnii-1 designed phages given to a human patient
> Claude: 17 scorpion-toxin binders validated in the lab
> OpenAI: acquired Orchestra Bio
> OpenAI + PerturbAI: agents found new neurodegeneration leads in 32 minutes
> RFD4-Proteina: open programmable protein design model
> BioEmu2: new biomolecular simulation model
> Chaperone: agent framework connecting 50+ protein design tools
> Xaira: launched X-Scientist for agentic drug discovery
> Sophont: Holon-S1 predicts gene activity from pathology slides
> Boltz + BMS: bringing biomolecular models into pharma workflows
> Phylo + Bayer: deploying Biomni Lab across research teams
> Kevin Weil, ex-OpenAI, launches Warp Sciences: AI + robotic labs for drug discovery
> Carbon-X: open DNA model its team says matches GPT-6.1 Sol at ~1,000x lower cost

This is happening across the whole stack: models, protein design, simulation, agents, robotic labs, pathology, pharma workflows, and actual patient use. Bio is becoming computer.

[Marc Landers @marclanders]

0.08 µg/ml (the main optimized concentration used for the key experiments). https://t.co/tGIaadgx5Y

This is an in vitro cell-culture study on human mesenchymal stem cells (MSCs), not a clinical or in vivo human dosing study. CBD concentrations were tested in the culture medium as follows:

Viability/cytotoxicity range (MTT assay): 0.04, 0.08, 0.16, 0.31, 0.63, and 1.25 µg/ml.

Concentrations ≥0.16 µg/ml reduced viability; the IC50 was ~0.37 µg/ml. Lower doses (especially 0.04 and 0.08 µg/ml) increased viability.

Gene-expression work (RT-PCR for SIRT1, stemness markers, autophagy genes, etc.): 0.04 and 0.08 µg/ml.

Main functional experiments (immunofluorescence for p-SIRT1 and LC3, SA-β-gal senescence assay, doubling time, telomere length/telomerase, long-term culture from passages 3–9): primarily 0.08 µg/ml.

The authors selected 0.08 µg/ml as the optimal concentration because it most effectively upregulated SIRT1 and autophagy markers, preserved stemness markers (SOX2, OCT4, NANOG), reduced senescence-associated markers, and supported proliferation/telomere function without cytotoxicity.

The CBD stock was prepared at 1,000 µg/ml in ethanol and diluted into the medium. https://t.co/tGIaadgx5Y

In short, the dose/concentration used for the positive findings was 0.08 µg/ml (80 ng/ml).

[Marc Landers @marclanders]

CBD Keeps Stem Cells Youthful for Brain Repair!

CBD slows cellular aging in stem cells, which are vital for tissue repair and brain regeneration.

It boosts SIRT1 (a "youth protein"), enhances autophagy (cellular cleanup), preserves stem cell potency, reduces aging markers, and protects telomeres.

This anti-aging effect could support long-term brain health.
https://t.co/q8TgYN40au

[Marc Landers @marclanders]

The study was funded by the Rocky Mountain Cannabis Research Center (via NIDA grant P50DA056408–02) and an NIMH training grant (T32MH015442–46). https://t.co/tGIaadgx5Y

These details appear in the Funding Information section of the full text on PMC (PMC12889878). The authors (including Anika Guha and Kent E. Hutchison at the University of Colorado Anschutz Medical Campus) report no conflicts of interest. https://t.co/tGIaadgx5Y

The underlying data came from the UK Biobank (a large UK cohort resource with its own separate funders, such as Wellcome and the MRC), but the analysis and this specific paper were supported by the U.S. NIH grants noted above.

[Marc Landers @marclanders]

@Sparky_Flush Links are in the individual posts. 😎

[Marc Landers @marclanders]

For you today!

Cannabis does NOT speed up cognitive decline or raise dementia risk in seniors!

Cannabis use in older adults is linked to brain networks that look younger!

Recreational Cannabis Users Report 96% LESS Brain Fog and Memory Issues.

[Marc Landers @marclanders]

@Cannascenti Thanks for your support! 😎

[Marc Landers @marclanders]

Out today!

CBN: Guardian of the Brain Against Aging and Disease?

CBD Keeps Stem Cells Youthful for Brain Repair!

Could CBD be a game-changer for Parkinson’s?

And more! Stay tuned!

[Marc Landers @marclanders]

@SwtCharlemaigne Thanks for the kind words and your support! 😎

[Marc Landers @marclanders]

I posted many studies yesterday about the neuro protection of cannabis. 😎

[Anthony Martinelli @AMartinelliWA]

A new case report authored by researchers from several universities and research institutions documents a brain cancer patient who regained the ability to walk and showed improvements on MRI scans while using cannabinoids and terpenes. https://t.co/SNlBOBhi1X

[Marc Landers @marclanders]

@dedskunks Thanks! 😎

[Marc Landers @marclanders]

Yeah! I made it!

I'm in the Original Content Rewards program!

Thanks to all of you!

I'll work even harder to bring you all great content! 😎

[Marc Landers @marclanders]

@Clear_Right_JP Thanks. I wasn't sure I'd make it as cannabis is such a contentious topic. 😎

[Marc Landers @marclanders]

Brain tumors shrink dramatically when treated with cannabis compounds!

Glioblastoma (brain cancer): Cannabinoids alone worked very well – they significantly shrank tumors.

Adding them to the standard drug temozolomide also helped.

Breast cancer: Cannabinoids reduced tumor size noticeably.

Synthetic cannabinoids + doxorubicin (a common chemo drug): Showed the biggest tumor shrinkage in breast cancer models.

Lung cancer and prostate cancer: Also showed good, significant tumor reduction.
https://t.co/vtOREBwKGA

[Marc Landers @marclanders]

Could CBD be a game-changer for Parkinson’s?

CBD helped more cells survive and reduced cell death caused by 6-HODA.

It lowered harmful ROS and cell membrane damage (MDA).

It boosted the cells’ antioxidant defenses (higher SOD, GSH, and total antioxidant capacity).

It increased protective genes (Nrf2, Bcl-2) and reduced harmful genes (Bax, Casp3). What does it mean?

It may protect nerve cells from damage like that seen in Parkinson’s disease.

It works by activating a pathway (Nrf2) that helps cells fight oxidative stress and damage.
https://t.co/8g0KZAYuUI

[Marc Landers @marclanders]

Cannabinoids Protect Against Tau Protein Damage

Substance abuse like alcohol and opioids can hyper phosphorylate tau protein, leading to brain decline similar to Alzheimer's.

But cannabinoids may protect by calming enzymes, reducing inflammation, and boosting brain flexibility (neuro plasticity).

This highlights cannabis's potential in countering drug-induced neuro degeneration.
https://t.co/k2bPBrDBts