STOPCAP at #ESMO26
Benefit of #radiotherapy in de novo M1 #prostatecancer on OS & PFS.
Restricted to <5 bone or low volume mets on conventional imaging.
No interaction with other patient/tumor characteristics.
Another proof that metastasis directed therapy improves outcomes, this time in castration resistant #prostatecancer
Congrats to the PCS IX team!
author link at @TheLancetOncol: https://t.co/SLt68cCuQP
Distant failure after SBRT for oligometastatic disease is a common pattern of progression.
Yet, we lack validated post-progression models to guide treatment.
We tested whether Distant Metastasis Velocity (DMV) can fill this gap - and validated it across multinational cohorts 🧵
🎗️Congrats to @NicolasDemogeot for this achievement.
✨ @GETUG_14, just published in
@EUplatinum
🔵 Phase III
🔵 376 pts (high risk and intermediate risk): high-dose RT versus STADT-RT
🔵'' High'' dose = 80 Gy
🔵 ADT decreased BF and MF but not OS
https://t.co/XXRM9jHM5T
❓ESTRO & EORTC proposed a classification to standardize reirradiation. But does it predict outcomes or toxicity?
🫁☢️ We applied the classification in thoracic reirradiation for NSCLC.
Here’s what we found.
🧵
1/ 🧨 OMET trial (GORTEC 2014-04) in oligometastatic HNSCC
👥 N=69, SABR alone vs SABR + chemo + cetuximab
🧪 Key finding: Similar 1-year OS without ⬇️QoL (SABR 55.2% vs chemo-SABR 53.3%).
🏆SABR alone had⬇️toxicity and QoL impact.
📉 Gr 3–4 tox: 8.8% (SABR alone) vs 60%
🧵
1/6 We selected five Editor's Choice articles from the last several months, based on importance to the multidisciplinary oncology community - all free to read.
https://t.co/0BRRhV9dXQ
In men diagnosed with GG1 prostate cancer undergoing active surveillance, higher adherence to American dietary guideline recommendations may be associated with a lower risk of grade reclassification. https://t.co/5u3ao6YM5z
Aiming to refine your #radonc in 2025 !
Offer RT for low-volume metastatic PC pts, only ?
What benefit of RT is to be communicated ?
How about SBRT or surgery ?
Virtual Grand Rounds in Radiation Oncology
Jan 8th / 17:00 - 17:30 CET
Dr Alberto Bossi
👇
https://t.co/VMPm8mqf0R
🎉 Excited to share our latest work: RadOncCalc – A Mobile-Friendly Tool to Enhance Radiation Oncology Practice 📱⚛️
How does RadOncCalc help radiation oncologists save time and enhance patient care? Let’s break it down in this Tweetorial!
https://t.co/i1ooN43w7v
🧵👇
📣@whallradonc presents phase II trial of dose escalated RT and elective nodes in VERY high risk #prostatecancer.
➡️10-year med. F/U
➡️>25% risk of clinical nodal involvement.
➡️outstanding 96% 10-year freedom from distant Mets
💥Hallelujah!
#pcsm#ASTRO24
Congrats to my friend @YG_TAO & GORTEC for this huge trial of IO in LA HNSCC
Avelumab-cetuximab inferior to cisplatin CRT in fit patients but superior to cetuximab-RT for PFS in cisplatin ineligible population.
#ESMO2024
In this nonrandomized controlled trial, olaparib monotherapy led to high and durable PSA50 response rates in patients with high-risk biochemically recurrent prostate cancer following prostatectomy. https://t.co/bnNEUS2ZSv
Online First:
Adaptive #radiotherapy (up to 74 Gy) or standard radiotherapy (66 Gy) for patients with stage III non-small-cell #lungcancer, according to [18F]FDG-PET uptake (RTEP7–IFCT-1402): a multicentre, randomised, controlled, phase 2 trial
https://t.co/nLnDsIzY8c
CARLHA Phase II trial @stephane_supiot
In @EurUrolOncol
👑 Salvage RT + sTADT + Abi :
- 3-yr bRFS = 81.5%
- most common late AE (all grades) was urinary incontinence (15.2%)
- 11% pts had a CTC count of ≥5, correlated with poorer bRFS (p = 0.042)
https://t.co/SqcvRFJBNi
Dose-escalated simultaneous integrated boost #radiotherapy in early #breastcancer (IMPORT HIGH): a multicentre phase 3 non-inferiority, open-label randomised controlled trial, published in @TheLancet
👉Read it before your patients: https://t.co/VCFWaO48xF
#ESTRONewsletter#radonc