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twitter_bio=input(soc_signals); Non-ergodic games. Heaven is a state of mind. laissez-faire. ἔρημος. Long humanity. mundum meliorum facite. veritas. Free

[iFunny Refugee @Dr_Magnusson1]

Immigration policy where we only let in countries that have discovered at least one element on the periodic table

[Schultz @RainingSchultz]

America is cool because whenever we take the wrong tech tree, a college dropout spawns to call you dumb and build the inevitable.

[James Russo @Rames_Jusso]

@OpenAI Codex and GPT 5.6 sol can now create your product walkthrough videos with @HeyGen + @HyperFrames_ .

I pointed Codex at the open-source HyperFrames repo.

It wrote the script, generated my avatar video, recorded the product, and rendered this video.

How to 🧵

[Andrew McCalip @andrewmccalip]

Less than 100 miles away, about 50 tons of steel and copper are spinning at exactly 3,600 RPM. A giant rotor slews magnetic fields through copper windings and, per Faraday and Maxwell, induces a synchronized 60 Hz sine wave across an entire grid.

That electromagnetic wave propagates through grain oriented silicon steel, laminated transformer cores, kilometers of aluminum conductor steel reinforced cable, SF₆ insulated switchgear, substations switching hundreds of kilovolts, distribution transformers, oxygen free copper wiring, silicon MOSFETs, ferrites, multilayer ceramic capacitors, and the USB C cable plugged into my phone.

There, power feeds a capacitive touchscreen. A transparent matrix of indium tin oxide is deposited on glass. The controller continuously scans the grid. My finger changes the mutual capacitance by a fraction of a picofarad, perturbing the local electric field just enough for dedicated analog front ends to detect before software reconstructs the touch.

Iron ore. Bauxite. Silica sand. Copper ore. Lithium brines. Rare earths.

Refined. Alloyed. Crystallized. Doped. Implanted. Deposited. Etched. Polished.

We purified sand into nearly perfect single crystal silicon, grew boules, sliced wafers, placed dopant atoms with nanometer precision, fabricated chips containing tens of billions of transistors, synchronized them with clocks billions of times per second, and engineered them to execute matrix multiplications at a scale no human could comprehend.

Somewhere along the way, matmuls started to look like us.

That is an astonishing thought.

The towers of abstraction are staggering. No one person built this. No one person fully understands it. Yet every morning millions of people wake up tired, answer emails, argue over specifications, chase margins, fix defects, make payroll, and try to cover their mortgages. Somehow the whole machine keeps humming.

A planetary Swiss watch assembled from physics, markets, bureaucracy, ambition, error, and human necessity.

And after all of that, I touch a piece of conductive glass and step into the Roman forum of modern thought, where millions of minds test ideas against one another in real time.

Clockwork humanity.

It staggers the mind.

[Dina D. Pomeranz 🟣 @DinaPomeranz]

Extreme poverty worldwide has never been as low as it is today, and it's never fallen as fast as in recent decades.

We need more facts and less ideology...

[clara the urbanist @SlopHq]

every data center story says it uses "as much power as 100,000 homes" like that's a scandal. an aluminum smelter pulls five times that and it's why airplanes are cheap. measuring industry in homes is how you train a country to believe building things is a crime

[C @matthew5johnson]

@xlaflammer @USMNT @Buck Awesome! What did you use for the Joe Buck voice?

[C @matthew5johnson]

@USMNTBaldEagle @guitarm3dic387 Not 100%. Many relatively unlikely, but mathematically possible scenarios remain in which Bosnia/Qatar win and don’t make it into the top 8 of third place teams. That is a bigger risk with a Qatar win due to their big negative goal diff

[TheTechDjinn @TheTechDjinn]

It's a trade off that PostgreSQL made by using heap tables. By using heap tables, it brings so much more to the table for PostgreSQL.

Also, the PostgreSQL engineers did recognize this penalty and created HOT (Heap-Only Tuples) that can dramatically even out-pace MySQL index updates. The downside of that is the columns have to have enough free space for it to be possible. Otherwise, it falls back to standard index updates.

[Possum Reviews @ReviewsPossum]

Last night, I read the entirety of C.S. Lewis' The Screwtape Letters. It's a novel told in the form of letters written by a demon to another demon instructing him on ways to manipulate his "patient" to do evil.

This one quote sounded familiar.

[Parth @mr_samosaman]

yesterday I danced to afrobeats in the sun while shipping a core feature for my startup. 5 giant Claudes floated around our terrace in my Vision Pro. I steered them by looking, pointing & speaking at them.

you now can buy Tony Stark's sci-fi workshop for ~$2k + a week of setup.

[Aakash Gupta @aakashgupta]

Mexico paid $20 million for eight minutes in this movie. Then those eight minutes forced them to invent an entire cultural tradition.

Before Spectre, Mexico City had no Day of the Dead parade. The holiday was celebrated at home, at cemeteries, with family altars. Quiet, intimate, centuries old. Sam Mendes fabricated a massive street parade for the opening sequence, shot it with 1,500 extras in skeleton costumes across the Zócalo, and audiences worldwide assumed they were watching a real annual event.

Mexico's government had negotiated hard for the placement. Leaked Sony hack emails showed officials offered up to $20 million in tax incentives for four minutes of positive portrayal. Sony was drowning in a $300 million budget. The deal included script changes: the Bond girl had to be a Mexican actress, the villain could not be Mexican, and the city's modern skyline had to appear on screen.

Then the movie opened in 182 countries and tourists started booking flights to Mexico City for the parade.

The parade that did not exist.

Tourism authorities panicked. Visitors were arriving expecting the spectacle they saw in the film and finding nothing. So in October 2016, the government spent $500,000, hired 650 volunteers, built dozens of floats and giant skeleton marionettes, and staged the first real Día de los Muertos parade in Mexico City's history. 250,000 people showed up. They openly called it a "Spectre-style parade" in press materials.

Ten years later, the parade draws millions. Anthropologists call it the "pizza effect," where a cultural element gets exported, transformed abroad, and reimported as authentic. Mexico's most famous public celebration of its most sacred holiday was invented by a British director shooting a $300 million spy movie.

That tracking shot is doing more for Mexico City's economy every November than the $20 million they paid for it.

[Afshine Emrani MD FACC @afshineemrani]

5/5
I want to be honest about what this moment means to me.
I'm a cardiologist. I have held dying hearts in my hands. I have watched 50-year-old fathers code on my table because plaque ruptured in an artery that looked "fine" last year. I have told wives their husbands aren't coming home.
To see a future where a single infusion prevents that plaque from ever forming. Where a vaccine hunts cancer before it takes root. Where metabolic disease is treated at its source before it ever reaches the heart.
This is beyond anything I imagined when I started in medicine.
Our children will live past 100 — not frail, not declining, but strong and vibrant and full of life. With gene editing, peptides, personalized vaccines, and the ancient wisdom of healthy living that has always been the foundation.
I have spent my career fighting diseases we could only manage. The generation that comes after us may never face them at all.
God is good. We are living in Messianic times.

[Swan @AndySwan]

You're much more of a slave to the 1% that commit 50% of crimes than you are to the 1% that create 40% of the wealth.

[Katie Lam @Katie_Lam_MP]

In 1980, we had one regulator for every 11,000 people working in financial services.

Today, it's closer to one regulator for every *75* people.

Bureaucrats always create more rules and always work to expand their powers. The idea that we can "regulate for growth" is ludicrous.

[Bryce Hanna @photobiogenesis]

When mPTP pores open it dramatically increases the permeability of the inner mitochondrial membrane

This rapidly dissipates the charge gradient, and is used to free radicals to signal stress to the cell nucleus, and with prolonged activation kills the mitochondria and cell

"Staying in the resting living state signifies being alive. Engaging in reversible shift between the resting and active living state represents life activity. Irreversible shift into the active state ends in the death state"
- Gilbert Ling

[Nick Norwitz MD PhD @nicknorwitz]

🚨New Paper: "Seven Years of 700 Cholesterol Without Coronary Atherosclerosis: A Lean Mass Hyper-Responder Case Report"

Link: https://t.co/5VnRpZlFdR

For the past 7 years, I’ve been running what is essentially a natural experiment in cholesterol and heart health.

During that time, I’ve largely lived with:

👉Total cholesterol around 700 mg/dl
👉LDL cholesterol between 500–600 mg/dL

I recently underwent advanced coronary CT angiography imaging with AI-guided analysis. This is not a CAC. It measures all plaque (soft + calcified), with expert interpretation and AI-guided analysis capable of quantifying plaque down to the cubic millimeter (mm3).

Now, to address the obvious question:

Am I too young for plaque?

In brief: No.

The clearest comparison is individuals with homozygous familial hypercholesterolemia, who often have similarly extreme LDL/ApoB levels and can develop advanced plaque as toddlers, and even heart attacks as early as age 8.

Also, nutrition influencers in their 30s have publicly shared quantified plaque scores from these same imaging technologies. In one recent case, a plant-based influencer in his thirties was found to have 61.3 mm³ of plaque despite having far lower lifetime LDL exposure. (He can identify himself if he so chooses.)

My case also isn’t a one-off.

There are many individuals like me, including older individuals with similar LDL-C and ApoB without any plaque.

The difference is that I’m an unusually well-characterized subject, with extensive metabolic data and health markers tracked over time. You can learn more at the newsletter or open-access paper, linked above.

The science of heart health is not settled. And cholesterol is not a simple story.

🚨 If you want to help spread the word...

Quote Tweet this post (or create an original post) including the article link with a thought. Academic papers are increasingly evaluated using attention metrics. Original posts from unique users are one way to increase these metrics and help ultimately increase its reach.

🚨 If you want to learn more, I'll include more learning resources below 👇

[Brandon Luu, MD @BrandonLuuMD]

Your phone impairs cognitive performance even when you’re not using it.

Turn it off and put it in another room.

[Nicolas Badre @BadreNicolas]

The odds of having dementia at age 85 were close to 1 in 3 in the 80s; now they are 1 in 10.

I don’t think we have a great explanation: better cardiovascular health, diet, and education are often mentioned. Good news nonetheless.

Carnall Farrar. (2025, March 27). Dementia trends.

[Joe Lonsdale @JTLonsdale]

What a naive and wrong point of view. So much of leftist politics and thinking these days is about justifying envy.

I’ve co-founded six different multi-billion dollar companies, with more on the way.

AOC perhaps isn’t bright enough to make a lot of money without massive grift - sure.

But 10000’s who worked with me are rich; some are also billionaires! Our innovation sector is the best in the world, solving problems and growing the pie with US talent for a brighter future for all.

I’m aligned against cronyism. But demonizing success is totally unAmerican.