The Maus Lab

Our group @VHIO helps innovation in oncology by dissecting how aging causes cancer and translating it into improved cancer diagnostics and therapeutics.

[The Maus Lab @maus_lab]

#JournalClub
Colorectal cancer is often taught as one clone expanding toward malignancy.

But what if early lesions are polyclonal?

Hu, He and colleagues propose that multiple clones can cooperate early, before later transition toward monoclonal states.
https://t.co/Yb588SO1nY

[The Maus Lab @maus_lab]

An almost empty 1970s-looking bar. An elderly owner solving crosswords. A few rundown tables. Two board games.

Not the obvious setting for a lab memory.

But playing miners and saboteurs there will quietly become part of our lab’s history.

[The Maus Lab @maus_lab]

What if precancerous selection is local?

Young et al. show that, in human bone marrow, clonal architecture can vary substantially within just millimeters of space.

A clue that local microenvironments may shape which clones expand.
#JournalClub

https://t.co/GpzuEPL9L3

[The Maus Lab @maus_lab]

Can the aged tissue microenvironment help predict cancer recurrence?

Welcome Adelina Gheorghe, a medical oncologist joining our team to test this question in the clinic and help move our findings toward better patient care.

[The Maus Lab @maus_lab]

Tumors don’t just experience stress — they weaponize it to evade immunity.
From our Journal Club: Bossowski et al. shows stressed tumor cells secrete LCN2, reprogramming macrophages to keep T cells out.
A link between stress responses and immune evasion.
https://t.co/UcaVRKfmb3

[The Maus Lab @maus_lab]

Your epigenome may record the exposures of your life.

At our Aging & Cancer Lab seminar, Silvana Maas (Seoane Lab) showed how lifestyle and environmental exposures leave marks on DNA that can be decoded to reconstruct exposures linked to early-onset colorectal cancer.

[The Maus Lab @maus_lab]

#JournalClub

Immune escape may be less about missing immune cells and more about how tumors reprogram surrounding stroma.

Ye et al. implicate senescent CAFs.
It raises a larger question: what gives rise to stromal states that constrain immune control?

https://t.co/y8Fy0MC2Ue

[The Maus Lab @maus_lab]

#JournalClub
Why does immunotherapy fail in most colorectal cancers?

Recent study shows it is not T cells, but TGF-β signaling in myeloid cells that blocks immune control. Turning it off restores T cell response.

Are myeloid cells the missing lever?

🔗 https://t.co/QKasBehHgu

[The Maus Lab @maus_lab]

Eric J. Chow et al. find that dexrazoxane given with doxorubicin in childhood cancer is linked to improved long-term cardiac function and lower risk of poor left ventricular function in adult survivors.
#JournalClub

https://t.co/O6DbevW8vp

[The Maus Lab @maus_lab]

Piotr et al. report that intravenous iron in a mouse cancer model increases tumor iron, promotes tumor growth, and blunts anti-tumor CD8⁺ T cell responses, reducing immunotherapy/chemo efficacy.
#JournalClub

https://t.co/Zc55sqzrxl

[The Maus Lab @maus_lab]

A shared DNA methylation drift occurs with aging and tumorgenesis in the colon. Age-related inflammation and reduced Wnt signaling, which dysregulate iron metabolism and impair TET activity, drive this epigenetic drift.
#JournalClub
https://t.co/43mtQNwRCq

[The Maus Lab @maus_lab]

Ferritin buffers intracellular iron and protects cells from iron toxicity. Yi et al. show that deleting the ferritin heavy chain (Fth1) impairs normal HSPC function but restricts AML progression and prolongs survival in mice.
#JournalClub

https://t.co/TCnkPAKk5A

[The Maus Lab @maus_lab]

A healthy forty-year-old swallows a pill every morning, not because they are ill, but to shape what might happen decades later.

Ten Drugs by Thomas Hager shows how medicines reshape not only health, but how we think, live, and build societies.
#labreads

https://t.co/Io06INUw2r

[The Maus Lab @maus_lab]

A healthy forty-year-old swallows a pill every morning, not because they are ill, but to shape what might happen decades later.

Ten Drugs by Thomas Hager shows how medicines reshape not only health, but how we think, live, and build societies.
#labreads

https://t.co/Io06INUw2r

[The Maus Lab @maus_lab]

Meet Jie, our newest PhD student. She brings out-of-the-box mechanistic ideas on how myeloid cell metabolism links aging and cancer—and, unexpectedly, serious karaoke skills. We are lucky to have her on the team.

https://t.co/WtoxWNQ3ul

[The Maus Lab @maus_lab]

Sherpas evolved a rare EPAS1 variant to thrive in low oxygen on the Tibetan plateau. In our A&C Lab Seminar Series, Carlota Arenillas showed how the same EPAS1 variant is selected in hypoxic tumors—convergent evolution across scales. 🧬

https://t.co/GalKaCxOwB

[The Maus Lab @maus_lab]

Cancer isn’t supposed to strike in adolescence or young adulthood — yet when it does, patients face threats to fertility, disrupted identity and education, and cancers beyond the scope of most oncologists.

Dr. Paula Pérez, showed us how she and Vall d´Hebron are changing this.

[The Maus Lab @maus_lab]

Cancer isn’t supposed to strike in adolescence or young adulthood — yet when it does, patients face threats to fertility, identity and education, and cancers beyond the scope of most oncologists.
This week Dr. Paula Pérez showed us how she and Vall d’Hebron are working for change

[The Maus Lab @maus_lab]

When Ning, Francesca & Marc were selected to speak @SENESCEL 2025, they gave it their all, refining every argument and minute.
Their talks put our metabolic bottleneck model of aging on the field’s radar. 👏

What do you think drives tissue aging, the cell or its environment? 🤔

[Mate Maus @MateMaus]

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