Our group @VHIO helps innovation in oncology by dissecting how aging causes cancer and translating it into improved cancer diagnostics and therapeutics.
#JournalClub
Colorectal cancer is often taught as one clone expanding toward malignancy.
But what if early lesions are polyclonal?
Hu, He and colleagues propose that multiple clones can cooperate early, before later transition toward monoclonal states.
https://t.co/Yb588SO1nY
An almost empty 1970s-looking bar. An elderly owner solving crosswords. A few rundown tables. Two board games.
Not the obvious setting for a lab memory.
But playing miners and saboteurs there will quietly become part of our lab’s history.
What if precancerous selection is local?
Young et al. show that, in human bone marrow, clonal architecture can vary substantially within just millimeters of space.
A clue that local microenvironments may shape which clones expand.
#JournalClub
https://t.co/GpzuEPL9L3
Can the aged tissue microenvironment help predict cancer recurrence?
Welcome Adelina Gheorghe, a medical oncologist joining our team to test this question in the clinic and help move our findings toward better patient care.
Tumors don’t just experience stress — they weaponize it to evade immunity.
From our Journal Club: Bossowski et al. shows stressed tumor cells secrete LCN2, reprogramming macrophages to keep T cells out.
A link between stress responses and immune evasion.
https://t.co/UcaVRKfmb3
Your epigenome may record the exposures of your life.
At our Aging & Cancer Lab seminar, Silvana Maas (Seoane Lab) showed how lifestyle and environmental exposures leave marks on DNA that can be decoded to reconstruct exposures linked to early-onset colorectal cancer.
#JournalClub
Immune escape may be less about missing immune cells and more about how tumors reprogram surrounding stroma.
Ye et al. implicate senescent CAFs.
It raises a larger question: what gives rise to stromal states that constrain immune control?
https://t.co/y8Fy0MC2Ue
#JournalClub
Why does immunotherapy fail in most colorectal cancers?
Recent study shows it is not T cells, but TGF-β signaling in myeloid cells that blocks immune control. Turning it off restores T cell response.
Are myeloid cells the missing lever?
🔗 https://t.co/QKasBehHgu
Eric J. Chow et al. find that dexrazoxane given with doxorubicin in childhood cancer is linked to improved long-term cardiac function and lower risk of poor left ventricular function in adult survivors.
#JournalClub
https://t.co/O6DbevW8vp
Piotr et al. report that intravenous iron in a mouse cancer model increases tumor iron, promotes tumor growth, and blunts anti-tumor CD8⁺ T cell responses, reducing immunotherapy/chemo efficacy.
#JournalClub
https://t.co/Zc55sqzrxl
A shared DNA methylation drift occurs with aging and tumorgenesis in the colon. Age-related inflammation and reduced Wnt signaling, which dysregulate iron metabolism and impair TET activity, drive this epigenetic drift.
#JournalClub
https://t.co/43mtQNwRCq
Ferritin buffers intracellular iron and protects cells from iron toxicity. Yi et al. show that deleting the ferritin heavy chain (Fth1) impairs normal HSPC function but restricts AML progression and prolongs survival in mice.
#JournalClub
https://t.co/TCnkPAKk5A
A healthy forty-year-old swallows a pill every morning, not because they are ill, but to shape what might happen decades later.
Ten Drugs by Thomas Hager shows how medicines reshape not only health, but how we think, live, and build societies.
#labreads
https://t.co/Io06INUw2r
A healthy forty-year-old swallows a pill every morning, not because they are ill, but to shape what might happen decades later.
Ten Drugs by Thomas Hager shows how medicines reshape not only health, but how we think, live, and build societies.
#labreads
https://t.co/Io06INUw2r
Meet Jie, our newest PhD student. She brings out-of-the-box mechanistic ideas on how myeloid cell metabolism links aging and cancer—and, unexpectedly, serious karaoke skills. We are lucky to have her on the team.
https://t.co/WtoxWNQ3ul
Sherpas evolved a rare EPAS1 variant to thrive in low oxygen on the Tibetan plateau. In our A&C Lab Seminar Series, Carlota Arenillas showed how the same EPAS1 variant is selected in hypoxic tumors—convergent evolution across scales. 🧬
https://t.co/GalKaCxOwB
Cancer isn’t supposed to strike in adolescence or young adulthood — yet when it does, patients face threats to fertility, disrupted identity and education, and cancers beyond the scope of most oncologists.
Dr. Paula Pérez, showed us how she and Vall d´Hebron are changing this.
Cancer isn’t supposed to strike in adolescence or young adulthood — yet when it does, patients face threats to fertility, identity and education, and cancers beyond the scope of most oncologists.
This week Dr. Paula Pérez showed us how she and Vall d’Hebron are working for change
When Ning, Francesca & Marc were selected to speak @SENESCEL 2025, they gave it their all, refining every argument and minute.
Their talks put our metabolic bottleneck model of aging on the field’s radar. 👏
What do you think drives tissue aging, the cell or its environment? 🤔