Max Gemmer

PhD student at Utrecht University. Interested in Cryo-ET, protein biogenesis, endoplasmic reticulum.
#TeamTomo #CryoEM #SciArt

[Max Gemmer @MaxGemmer]

Very happy to share our recent work on protein biogenesis at the ER membrane. We analyzed 150,000 ribosomes from 1000+ tomograms of ER-derived vesicles to visualize ribosome intermediates and their downstream translocon machinery.
1/

#TeamTomo #CryoEM
https://t.co/MXeQ598RvZ

[Ariane Briegel @BriegelAriane]

You always wanted a book on cryo- electron tomography, written by the leading experts in the field? I have good news-You can now pre- order this book, edited by the one and only @FriedrichForst1 and myself! https://t.co/4xM1geVTD5

[Alex J Noble @alexjamesnoble]

Muyuan has been working on this for some time, it's cool to see a manuscript: How to create full, atomic resolution scenes of biomolecules in Unreal Engine and fly around them in real-time. Really cool stuff with untapped potential.
https://t.co/dWQ6nhRnNJ
https://t.co/oRDsvwECgj

[Max Gemmer @MaxGemmer]

@v_paavilainen Thank you, Ville!

[Max Gemmer @MaxGemmer]

How is the biogenesis machinery organized to produce multispanning membrane in humans? In our most recent preprint, we characterize the composition of the multipass translocon in its native membrane environment using cryo-ET.
🧵
#TeamTomo #cryoEM
https://t.co/SyLSTqEAWs

[Ville Paavilainen 🇫🇮🇺🇦 @v_paavilainen]

Happy to report our new structure of Sec61 and the TRAP complex out now in @emboreports! This has been a nice group effort with us @BIOTECH_UH and with @JuhaHuiskonen and @LHapponen @lunduniversity.
https://t.co/iRd0CzMy6L

[Max Gemmer @MaxGemmer]

@v_paavilainen @hauryliuk @emboreports @BIOTECH_UH @JuhaHuiskonen @LHapponen @lunduniversity Congratulations to the paper and preprint! 🎉

[Max Gemmer @MaxGemmer]

9 | Big thanks to @ChailletMarten, @FriedrichForst1, and the rest of our team for their contributions. The full raw data set of unperturbed ER-derived vesicles from this and our previous paper is now also available online https://t.co/bYz7K3PWVy

[Max Gemmer @MaxGemmer]

8 | The function and interplay between TRAP, NOMO, and NCLN remains largely obscure. The architecture of the BOS complex (NCLN-NOMO) and its interaction with the insertase EMC was now characterized by the @voorheeslab. Check out their paper, too!
https://t.co/VNqE1sKuEo

[Felix Bäuerlein @FelixBauerlein]

We developed "DeepFIBing" - a new strategy to create #cryoFIB-lamellae for #cryoET in any depth of very large cells - this also works for tissue. If you want to know more, have a look into our publication in CELL with @jentoft_ida and @SchuhLab. #teamtomo https://t.co/O4qWvG4uiT

[Max Gemmer @MaxGemmer]

@DanielHurdiss @FriedrichForst1 @ChailletMarten Thank you, Dan!

[Max Gemmer @MaxGemmer]

I successfully defended my PhD thesis on protein biogenesis last week. I am really grateful to my supervisor @FriedrichForst1, colleagues and friends for this wonderful experience! In particular Juliette Fedry and @ChailletMarten who significantly contributed to our projects.

[Max Gemmer @MaxGemmer]

@FriedrichForst1 Thank you so much Friedrich!

[Max Gemmer @MaxGemmer]

@BriegelAriane @FriedrichForst1 @ChailletMarten Thank you!

[Max Gemmer @MaxGemmer]

@xlinkx_pd @FriedrichForst1 @ChailletMarten Thank you Richard!