@uronote hits double figures next Friday 13th June with a session on UTUC. Brilliant panel including Kay Thomas, Mark Cutress and Nottingham's very own @davidbratt17
Michael Longley CBE
1939-2025
As I post these portraits of my dear friend today, I am filled with sadness. And a great sense of pride. Michael was one of the Belfast greats. One of the Irish greats. One of the world’s greats. 1/4
The Proteogenomics of Prostate Cancer Radioresistance out on @CRC_AACR
https://t.co/eCdjzb1ANQ
#ProstateCancer radioresistance☢️ remains a challenge in radiotherapy, with aggressive relapses often occurring, but the underlying molecular mechanisms are not well understood.
This study analyzed the genomic🧬 transcriptomic, and proteomic profiles of prostate cancer cells exposed to both conventional and hypofractionated radiotherapy, revealing that radioresistance is associated with genomic instability and impaired DNA mismatch repair, regardless of the treatment regimen. Key cancer driver genes exhibited distinct RNA and protein-level changes, with conventional fractionation triggering a more aggressive biomolecular response than hypofractionation.
The study identified POLQ (DNA Polymerase Theta) as a promising radiosensitizer, demonstrating its ability to modulate radioresistance and predict treatment outcomes in patient cohorts, providing new insights into the lethal nature of prostate cancer.
@HaasRoni@bethneilsen@Chenghao_Zhu@DrAndrewLoblaw@dr_vesi@AmarUKishan@DrMLChua@KislingerThomas@DrStanLiu
In England, we currently have many GPs unable to find permanent posts whilst at the same time patients are struggling to get appointments with their own GP. The next government must invest in core GP services to expand capacity and give people the care the primary care they need.
It’s been a long wait but @soph_cash and I are delighted to share Episode 1 of The second series of #FRCSUrocast - we start off by tackling Uroradiology with the assistance of our special guest, the fabulous @drrachelhubbard.
https://t.co/scSHPsSHhO
WIN! - A Copy of New Order’s ‘Substance’
Like, retweet, and give us a follow to be entered into our competition to win one of the all-time best compilations.
The remastered reissue is released next Friday on 2LP vinyl, 2CD, and an expanded 4CD box set.
https://t.co/Na6P8FMS5H
As we commemorate the anniversary of her passing, we pay tribute to Mary Ann McCracken. To this day she remains an inspiration as a trailblazing social activist & member of #TheLinenHall. Her commitment to abolitionism & women's rights resonates as a beacon of hope and courage 💪
⭐️ The EAU guidelines on focal HIFU and focal cryotherapy have changed ⭐️
For advice on eligibility criteria & how patients can access focal HIFU or cryo routinely via HEAT and ICE registries, DM or email.
@UkFocal@FocalSociety@IP_London