Working on a very cool @darwintreelife assembly today.
Haplotype resolved assembly of PENTAPLOID Rosa agrestis.
They have asymetric meiosis with two chroms forming bivalents and the other three inherited as univalents through the egg.
Spot the bivalent pairs in the HIC map.
Excited to announce our new review: Beyond the Human Genome Project: The Age of Complete Human Genome Sequences and Pangenome References. w/ @BenedictPaten @rajivmccoy@khmiga@EimearEKenny et al. https://t.co/3lCv6qoWby
Interesting #AssemblyCuration today @SangerToL. HiC-phased diploid assembly of a dragonfly. Curating both haplotypes together in a merged map. Pics show X and Y sex chromosomes that were mashed up between the haps and also lots of false duplication by hifiasm to be removed.
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In this preprint, Aylwyn Scally, Richard Durbin and I present evidence for deep population structure shared by all modern humans https://t.co/SuKa5I4Dqj @aylwyn_scally@richard_durbin
First step in a community project to provide a uniformly assembled, annotated and searchable set of bacterial genomes, our preprint on our initial release of 1.9 million genome assemblies+taxonomic estimates. (figure compares with previous 661k dataset)
https://t.co/RLQiUBZJNk
Delighted this is out, led by @bricoletc , culmination of 10 yrs of work,started by Sorina Maciuca. New genome graph methods took a lot of work, but paid off, and Brice showed gene conversion between genes explained unusually deeply diverged lineages in 2 surface antigen genes.
I worked in Shane's team for 4 years. They were some of the best years of my life. One of the positions is to replace me. Our DToL project is wonderful. I'm still in the project, just in another position now. Apply today! @darwintreelife
We're also seeking a Principal Computer Scientist - someone to lead on algorithm and method development for genome assembly - so many challenges still remain from polyploids, to very large genomes, and complex symbiotic mixtures (https://t.co/68QzaUS4PG). Come join us!
There are two senior/bioinformatician roles to work on genome assembly, data analysis and the development of methods and software to support assembling genomes across diverse taxa from the Tree of Life (https://t.co/s8zqB6fDf3).
@nature_spotter @mprous1@StevenFalk1 Upstream from me 😁. Suggest contacting [email protected] who can put you in contact with Caroline’s core lab team. They’ll likely ask about how the samples were preserved…
I've been dying to tell you all! I'm going on a national tour in 2023 representing the Australian Institute of Physics @ausphysics Looking forward to meeting lots of people as the Women in Physics lecturer.
https://t.co/XdJgWb3WLz
we are delighted to see the first of many @WellcomeOpenRes genome notes for Anopheles now out. this first one is a single insect @PacBio HiFi assembly for the major malaria vector Anopheles funestus. https://t.co/Ha3rNowwxM 1/n
Read our #DarwinTreeOfLife article for @NatureEcoEvo, where we ask "Does #genome size matter?"
For our scientists, trying to work out resources needed for each species, the answer is a resounding "yes!"
Find out more: https://t.co/j9O7nzBcmT
@KewScience @CibeleCaio@mcshane
Safely sharing non-identifiable sequences from private cohorts of complete genome assemblies: https://t.co/UjRZCtPaMI (Or: How to build a global pangenome from siloed data)
We are recruiting for the Tree of Life Assembly team here @sangertol. With >500 genomes down, we are on our way to the @darwintreeoflife goal of generating high quality chromosomal assemblies for all eukaryotic species in the UK, but there are many challenges remaining.