MD Biosciences Neuro

#Preclinical CRO that specializes in #pain and #neurodegenerative diseases. Our #Neurological & #CNS research services focus on clinically-relevant read outs

[MD Biosciences Neuro @mdbneuro]

In a head-to-head comparison of local anesthetics in pig postoperative pain, Exparel, Marcaine, and Naropin ranked in exactly the order observed in human clinical data (Castel et al., 2017, J Pain Res). Translational value for pain drug decisions. #PainResearch #Preclinical

[MD Biosciences Neuro @mdbneuro]

Pharmacological validation in the MD Biosciences pig PNT model: gabapentin reverses mechanical allodynia; aprepitant does not. Mirrors human clinical outcomes. Full datasheet with behavior, histology, and electrophysiology endpoints at https://t.co/mNOfjQqFOP.

[MD Biosciences Neuro @mdbneuro]

Psychiatric drug safety beyond behavior. MD Biosciences runs a Göttingen minipig aggressiveness model (risperidone 2 mg/kg reduced dominance behavior, p<0.001), and vitro cortical neuron screening for relative BDNF intensity and synaptic density and strength.

[MD Biosciences Neuro @mdbneuro]

In a porcine intradermal bupivacaine PK study, female animals showed peak blood concentrations approximately twice those of males (approx. 6,000 ng/ml vs 3,000 ng/ml, same 8 mg/kg dose). A 2x exposure difference by sex, measurable preclinically #Pharmacokinetics #SexDifferences

[MD Biosciences Neuro @mdbneuro]

In MD Biosciences SCI models, female Sprague-Dawley rats show greater tcMEP amplitude at 16 weeks post-injury than males. Sex as a design variable in SCI efficacy studies is not optional.

[MD Biosciences Neuro @mdbneuro]

🔬 Read the abstract: https://t.co/z4dZvmFtxM

[MD Biosciences Neuro @mdbneuro]

Sex differences may influence systemic drug exposure.

Female Göttingen minipigs showed higher exposure and delayed Tmax after bupivacaine administration in a recent MD Biosciences study.

Read the abstract:
https://t.co/VCx5K8hkYl

#pharmacokinetics #largeanimalmodels

[MD Biosciences Neuro @mdbneuro]

Rodent data often looks strong early. But predictability can decline later when translational questions around scale, delivery, durability, or procedures haven’t been evaluated.

See where these challenges emerge: https://t.co/IBuRdMcLBO

#TranslationalScience #DrugDevelopment

[MD Biosciences Neuro @mdbneuro]

MEP recordings in our SCI pig model show that immediate post-injury electrophysiology predicts functional recovery.

https://t.co/1WwSLHN6Kf

#preclinicalresearch #spinalcordinjury #electrophysiology #pigmodels #rodentmodels

[MD Biosciences Neuro @mdbneuro]

Our programs are supported by AAALAC International accreditation, NIH OLAW Foreign Assurance, and a purpose-built GLP translational research facility.

https://t.co/QBL9NhOQvG

#AAALAC #PreclinicalResearch #DrugDevelopment

[MD Biosciences Neuro @mdbneuro]

We're now accredited by AAALAC International! What this means for partners:
-Independent validation of animal care program
-Stronger data reliability
-Reduced regulatory risk
-Confidence that research is ethical

#AAALAC #PreclinicalResearch #GLP #TranslationalScience

[MD Biosciences Neuro @mdbneuro]

Curious about large animal models? Learn how pigs provide more clinically relevant data than rodents in preclinical research for CNS, pain, and wound healing. 🐖
Download the full paper here: https://t.co/7boG8UsyQK

#PreclinicalResearch #LargeAnimalModels #TranslationalResearch

[MD Biosciences Neuro @mdbneuro]

🔍 Advanced AI tools are transforming preclinical wound healing research. DeePathology’s AI-based quantitative histopathology identified and measured key healing markers in a Göttingen minipig burn model. https://t.co/fHWrdoaj8M

#PreclinicalResearch #TranslationalResearch

[MD Biosciences Neuro @mdbneuro]

In many programs, early-stage data is strong. As programs advance, predictability decreases because key translational assumptions have not been addressed. https://t.co/SHBwnL7i4C

#PreclinicalResearch #DrugDiscovery #Neuro #TranslationalResearch #PigModels #GLP #LargeAnimalModels

[MD Biosciences Neuro @mdbneuro]

Predictability is lost later because translational assumptions haven’t been evaluated early.

We mapped where this happens and why it’s difficult to detect early: https://t.co/KfuLCRpjv5

#Preclinical #Neuroscience #TranslationalResearch #GLP #LargeAnimalModels

[MD Biosciences Neuro @mdbneuro]

From acute to chronic inflammation, including rheumatoid arthritis and osteoarthritis, our translational models measure immune activation, tissue changes, and therapeutic effects with clinically relevant endpoints. Learn more here: https://t.co/Bl9u1uwiVk

#PreclinicalModels

[MD Biosciences Neuro @mdbneuro]

Join us at the Non-Opioid Pain Summit! We’re eager to connect with experts advancing non-opioid pain management and share how our preclinical models support this important research.

https://t.co/LwIdZeFDhx

#nonopioidpainsummit #painresearch #translationalresearch #neuroscience

[MD Biosciences Neuro @mdbneuro]

We are excited to introduce new models and cutting-edge tools designed to accelerate your research in 2026. Read our 2026 service catalog here:
https://t.co/EyOnUfI51i

#PreclinicalResearch #DrugDiscovery #Neuroscience #TranslationalResearch

[MD Biosciences Neuro @mdbneuro]

Advancing preclinical research requires models that reflect real-world diversity. Learn about case studies in our whitepaper that strengthen translational relevance.

📄https://t.co/VNkdB4MoZg

#TranslationalResearch #PreclinicalResearch #DrugDevelopment #EfficacyStudies

[MD Biosciences Neuro @mdbneuro]

Final day at SfN! 🧠 We’ve had a great week connecting with the neuroscience community. If you’re still here, swing by booth 820 before the day ends.

#SfN2025 #SfN25