Megan Joseph, PhD

Post doctoral researcher with the Jungmann lab studying T cell synapses using DNA-PAINT microscopy. MPIB She/Her.

[Megan Joseph, PhD @MDJoseph97]

Incredibly proud to share that my PhD work is out in Science Signaling and made it to the journal cover!!🥳 Congratulations to all authors and a massive thank you to my supervisors @ssimoncelli and Prof. Andrew Cope.

[Science Signaling @scisignal]

A new imaging analysis uncovers an important molecular brake on T cell remodeling and activation, in vitro experiments reveal an unexpected role for the cell cycle regulator CDK1, and more this week in #ScienceSignaling. https://t.co/pqaGMgtKQm

[Genetic Engineering & Biotechnology News @GENbio]

T-Cell Synapse Formation Is Restrained by PTPN22–PSTPIP1 Signaling

T‑cell synapse remodeling depends on a PTPN22–PSTPIP1 axis that restrains actin dynamics and may offer insights into #autoimmunity
@MDJoseph97 @ssimoncelli @ucl
#cancerimmunotherapy #Tcell
https://t.co/pa8RNB6TF3

[Science Signaling @scisignal]

How do T cells restrain their activation?

A team applies DNA-PAINT to visualize the immunological synapse and shows PTPN22 restricts actin remodeling and antigen sensitivity by interacting with PSTPIP1 at the plasma membrane. @MDJoseph97 @ssimoncelli https://t.co/JuJucH35IA

[Sabrina Simoncelli @ssimoncelli]

New paper out in @SciSignal — and we made the cover! 🎉 We uncovered a new role for autoimmunity gene PTPN22 in shaping the T cell immunological synapse.

https://t.co/wjhBUQntW9

A thread 🧵 1/6

[Megan Joseph, PhD @MDJoseph97]

@ceciliazaza @oliviapldalby @ssimoncelli 🥳🥳🥳🥳🥳

[Megan Joseph, PhD @MDJoseph97]

@SteveTheChemist @ssimoncelli Thank you!

[Megan Joseph, PhD @MDJoseph97]

It was a wonderful moment celebrating my PhD graduation! Thank you to everyone who helped me along the way. Especially my primary supervisor @ssimoncelli

[Megan Joseph, PhD @MDJoseph97]

New paper from the Simoncelli lab!
It was truly an honour to work with this amazing bunch of researchers. Congratulations to all the authors 🥳

[Sabrina Simoncelli @ssimoncelli]

🚨 New paper alert! 🚨
Can we simultaneously achieve deep, high-res, large field-of-view imaging without the usual trade-offs? 🤔
🧬🔬 YES: #DNA_PAINT + Spinning Disk Confocal + Optical Photon Reassignment (#SDC_OPR)! #SuperResolution
📄 https://t.co/YKYgcDyMLG @NatureComms 🧵👇

[Megan Joseph, PhD @MDJoseph97]

@RetoPaul @JungmannLab Thank you! I believe so yes 😊

[Megan Joseph, PhD @MDJoseph97]

What a great way to announce my new post doctoral research position with the @JungmannLab by showing off my amazing graduation hat made by my fellow lab members! Thank you all for my wonderful gifts.

[Megan Joseph, PhD @MDJoseph97]

@SteveTheChemist @ssimoncelli @uclbiosciences @LondonNanotech @KingsCollegeLon @LIDo_DTP Thank you!

[Megan Joseph, PhD @MDJoseph97]

Thrilled to announce that yesterday I passed my PhD viva examination 🥳 Thank you to my supervisors for all their support @ssimoncelli and Prof. Andrew Cope and to @uclbiosciences, @LondonNanotech @KingsCollegeLon, and @LIDo_DTP. Here are some celebratory Simoncelli lab photos

[Megan Joseph, PhD @MDJoseph97]

@coffee_lipe @ssimoncelli @uclbiosciences @LondonNanotech @KingsCollegeLon @LIDo_DTP Thank you!

[Megan Joseph, PhD @MDJoseph97]

Thank you also to @Orbyts1, I wouldn't have got here without you!

[Megan Joseph, PhD @MDJoseph97]

@MDV_Lab @ssimoncelli @uclbiosciences @LondonNanotech @KingsCollegeLon @LIDo_DTP It really does!

[Megan Joseph, PhD @MDJoseph97]

@l_masu @ssimoncelli @uclbiosciences @LondonNanotech @KingsCollegeLon @LIDo_DTP Thank you! ❤

[Sabrina Simoncelli @ssimoncelli]

Thrilled to share our latest work in @NanoLetters! Can we measure association and dissociation constants within cell environments? Check out how we use single-molecule localization microscopy to determine protein-protein interactions in T cells. 🥼🔬 💪 https://t.co/kDZzgdfe0s

[Martijn Zwijnenburg @ZwijCompChem]

Megan Joseph from the Simoncelli group gives the third talk of the annual @UCLChemistry Ramsay Medal Symposium about her work on studying immune cells with super resolution microscopy

[Megan Joseph, PhD @MDJoseph97]

@coffee_lipe Thank you Felipe! Hope you're enjoying the post-doc!

[Megan Joseph, PhD @MDJoseph97]

Thank you so much Sabrina for helping me start my scientific journey and all your support over the last four years! I'm honoured to have been your first PhD student and I've learnt so much from you.

[Sabrina Simoncelli @ssimoncelli]

Congrats to my first PhD student, Megan @MDJoseph97, on submitting her thesis today! 🎉 It’s been an absolute honor to supervise you, and I’ve learned so much from your incredible work. Best of luck in your new postdoc – I know you’ll do wonders! 🌟 #ProudSupervisor #NextChapter

[Megan Joseph, PhD @MDJoseph97]

@_AishaMumtaz_ Thank you!