Lesli Lord

An oncology professional inspired by #Cancer #PrecisionMedicine #Patients #Survivors #CommunityOncology #HealthcareReform

[Lesli Lord @MDTweetThyself]

@F5Video @kfor We are sitting in the dark 🤦‍♀️

[Eric Topol @EricTopol]

The ramp up of cancer immunotherapy is remarkable. Now we're seeing vaccines achieve some cures or remissions in the most refractory cancers: pancreatic, melanoma, glioblastoma, renal, triple-negative breast cancer.
✓ out the new Ground Truths (link in profile)

[Dr. Pat Soon-Shiong @DrPatrick]

As predicted in our Nant Cancer vaccine patent. Most excited to see the readout of the Lynch Syndrome trial to prevent cancer. 2 year follow up coming by next year. NK cell stimulation happening so far.

[Anish Moonka @anishmoonka]

Winston Churchill fought his depression with bricks. He'd lay them for hours at his country home in Kent. He joined the bricklayers' union. And in 1921 he wrote about why it worked. It took psychology another 75 years to catch up.

He called his depression the "Black Dog." It followed him for decades. His method for fighting it back was as basic as it sounds: laying brick after brick, hour after hour.

Churchill spelled out his theory in a long essay for The Strand Magazine. People who think for a living, he wrote, can't fix a tired brain just by resting it. They have to use a different part of themselves. The part that moves the eyes and the hands. Woodworking, chemistry, bookbinding, bricklaying, painting. Anything that drags the body into a problem the mind can't solve by itself.

Modern psychology now calls this behavioral activation. It's one of the most-studied depression treatments out there. Depression sets a behavior trap. You feel bad, so you stop doing things, and doing less means less to feel good about. Feeling worse makes you do even less. The loop tightens until you can't breathe inside it.

Behavioral activation breaks the loop from the action side. You schedule the activity first, even when every part of you doesn't want to. Doing it produces small rewards: a wall gets straighter, a painting fills in, a messy room gets clean. Those small rewards slowly rewire the brain. Action comes first, and the feeling follows.

Researchers at the University of Washington put this to the test in 2006. They studied 241 adults with major depression and compared three treatments: behavioral activation, regular talk therapy, and antidepressants. For the people who were most severely depressed, behavioral activation matched the drugs. It beat the talk therapy. A 2014 review of more than 1,500 patients across 26 trials backed up the result.

Physical work like bricklaying does something extra on top of this. It crowds out rumination, the looping bad thoughts that grind people down during the worst stretches of depression. Bricklaying needs both hands and gives feedback brick by brick: each one is straight or crooked. After an hour you can see exactly how much wall you built. No room left for the mental chewing.

The line George Mack used in his post, "depression hates a moving target," is good poetry. The science behind it is sharper. Depression hates a brain that has somewhere else to be.

[Lesli Lord @MDTweetThyself]

@elonmusk @mattvanswol I prefer to support local charities…better oversight

[Lesli Lord @MDTweetThyself]

@chrisbosh Inspirational!!

[Love Music @khnh80044]

Love it. We all need this kinda energy in our lives 😍🕺💃

[Lesli Lord @MDTweetThyself]

@JVMonte2 Imagine Dragons at the House of Blues in Dallas

[memes.xlsx @ExcelHumor]

when the excel formula works on the first try

[Wholesome Side of 𝕏 @itsme_urstruly]

That one employee who gives 110% at work 😂

[Zito @_Zeets]

The texts between Conan, Will Arnett, and Jason Bateman are hilarious. Conan lost both of his parents and somehow joking about Bateman killing them is so dark and yet such a sweet way to help a friend grieve.

[Lesli Lord @MDTweetThyself]

@EUROPEANRADARS Yes

[Lesli Lord @MDTweetThyself]

@Matt_Pinner Ruth

[Lesli Lord @MDTweetThyself]

@VisionaryxAI Yes 🤨

[Uncensored USA 🇺🇸 @UncensoredUSA]

You wanted an attack dog, you got it! 😂

[Spill The Memes @SpillTheMemes]

😂

[Eric Topol @EricTopol]

Our A.I. times ;-)

[National Park Service @NatlParkService]

The first five days after the weekend are always the hardest…

[Rod Laver @rodlaver]

Still taking in that incredible men’s final at Roland Garros. So happy for @carlosalcaraz - five Grand Slams at just 22! My heart goes out to Jannik Sinner, who showed real class in defeat. What a match, thank you both. Tennis is in great hands.🚀

[Roland-Garros @rolandgarros]

CARLOS ALCARAZ DID THE IMPOSSIBLE 🤯🏆

#RolandGarros