Out now in @Nature: our paper on multimodal precision diagnostics in clinical xenotransplantation. Hyperacute rejection is largely solved. The next challenge is the immune injury hiding below the surface, and we propose a framework to see it early. https://t.co/7HfFtEShCa
AKI in the 2 living recipients of pig hearts: acute tubular injury, but preserved podocytes and no glomerular immune deposits in native kidneys. This supports a graft-intrinsic immunologic origin for podocyte injury in pig kidney #xenotransplantation.
https://t.co/7P7derfeKa
New in @Nature: UMSOM researchers outline a roadmap for detecting immune rejection in pig-to-human organ transplants at the earliest, potentially reversible stage.
📰Read more: https://t.co/rZ6G9xpj6a
#Xenotransplantation
Out now in @Nature: our paper on multimodal precision diagnostics in clinical xenotransplantation. Hyperacute rejection is largely solved. The next challenge is the immune injury hiding below the surface, and we propose a framework to see it early. https://t.co/7HfFtEShCa
@meier_raphael@Nature@AlexandreLoupy@umms@ParisTxGroup Congrats on the Nature paper. Shifting the focus from hyperacute rejection to the quieter immune injury underneath feels like the right next step for xeno. Which of your modalities tended to flag that hidden injury first, and how far ahead of clinical signs?
@meier_raphael@Nature@AlexandreLoupy@umms@ParisTxGroup Incredible work! Moving beyond hyperacute rejection to tackle hidden immune injury early will transform clinical decision-making in organ transplantation. Exceptional research! 👏