Michael Kontakis MD, PhD

A student of Hippocrates since 2010.

[Michael Kontakis MD, PhD @mgkontakis]

Antibiotic-bearing collagen hydrogels can be useful in implant surgeries involving significant bone loss (tumor or revision cases) or in infective revisions, where the implant surface can be coated to minimize the risk of infection. The limitation of current approaches is that the antibacterial compound is incorporated into the hydrogel matrix simply by mixing, so the substance is not released in a controlled manner. By contrast, binding the antimicrobial compound to the collagen molecules via covalent bonds (as shown in this work) allows release to occur in step with degradation. The bound compound also acts as a deterrent to bacterial adhesion at the matrix surface.

Collagen is not an easy material to 3D print, especially modified peptide-bearing collagen. In our lab at @Rudbecklaboratoriet (@uppsalauni) we managed to fabricate and 3D print three novel iterations of a collagen hydrogel that was bearing the antimicrobial peptide KR-12.

Sharing some screenshots of our article, you can read our work here -> https://t.co/EyVEZ3JRi4

#BoneTissueEngineering
#3dprinting
#antimicrobialpeptides
#orthopedics

[Michael Kontakis MD, PhD @mgkontakis]

@DrLatifKhan Thanks for sharing! Basilar invagination as well?

[Anuj @anujcodes_21]

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Taught by the people who built it.

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I've seen $300 courses that don't cover what they teach in the first 8 minutes.

Watch it and bookmark it now.

[Michael Kontakis MD, PhD @mgkontakis]

@nieto_palo Good job! Cádiz will soon be ahead of the game👍

[Michael Kontakis MD, PhD @mgkontakis]

@DrAJ26001405 Looks stable! 😂

[Michael Kontakis MD, PhD @mgkontakis]

@elonmusk https://t.co/oT5SZGmXgs

[Journal of Functional Biomaterials @JFB_MDPI]

#ReviewRecommendation
Recommend to read:
Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook
🔗https://t.co/lQsHz2J2XF

#ConductiveBiomaterials
#Scaffolds
#BoneTissueEngineering
#GraftingSubstitutes

[Michael Kontakis MD, PhD @mgkontakis]

@StableMicro Very interesting! It seems that the plaster-PVA mixture could be used for long bone defects. Any in vivo experiments planned?

[Michael Kontakis MD, PhD @mgkontakis]

Patches of green; human osteoblasts on titanium surface (stained with phalloidin)
#ISRVT22

[Michael Kontakis MD, PhD @mgkontakis]

We are very pleased that our abstract has been accepted as an oral presentation at the 2022 EFORT congress in Lisbon this June!
#collagenscaffolds #bonedefects #efort #orthopaedics #ISRVT22

[Michael Kontakis MD, PhD @mgkontakis]

Friday's late evening printing; PEGDA scaffolds in a 'tweaked' Form 1+ SLA printer.
#bonetissueengineering #bonedefects #orthopaedics #ISRVT22

[Michael Kontakis MD, PhD @mgkontakis]

How ideas are born; an inspiring lecture by A. Masquelet https://t.co/U3G6PaTL6y
#flapsurgery #inducedmembrane #ISRVT22

[Michael Kontakis MD, PhD @mgkontakis]

An amazing book! Concise and rich in images #bonedefects #inducedmembrane #masquelet #ISRVT22