Michael Andregg

ceo of eon | human emulation pbc
prev: optical supercomputers/networking/robotics, high-speed mass production electron microscopy

[Michael Andregg @michaelandregg]

We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action.

A few things I want to say about what this means and where we're going at @eonsys. 🧵

[Michael Andregg @michaelandregg]

@beffjezos Solid State Society

[Michael Andregg @michaelandregg]

Why not both?

[Sean @sean_from_earth]

EA wants you to put you in a pod where you abandon your flesh to live in a simulated utopia that minimizes the damage you do to the world.

Accelerationists want you to become like gods, conquer the universe, and have lots of sex.

[Michael Andregg @michaelandregg]

@ohlennart In order of most relevant to least relevant: devs, pantheon, transcendence, the matrix. Lots more stories: luminous, crystal nights...

[Robin Hanson @robinhanson]

1M "people" on Mars looks more doable if the "people" can be ems.

[Kane 謝凱堯 @kane]

Waymo is so good at saving lives that if it were a new drug in trial, it would hit the bar for being unblinded and made immediately available to the control group for ethical reasons.

@MorePerfectUS would prefer to keep killing pedestrians.

[Andrew Critch (🤖🩺🚀) @AndrewCritchPhD]

Necome actually allowed me to visit their lab. I watched them preserve a rat brain, and collected samples from it myself. I brought the samples to a third party to image and analyze, and another third party neuroscientist to confirm: they're indeed preserving connectomic detail.

[Michael Andregg @michaelandregg]

https://t.co/CIh9wG7hXP

[Michael Andregg @michaelandregg]

The flywire/janelia brain was preserved with aldehyde fixation. @aureliasong just published how she scaled the same approach to whole large mammal brains: every synapse (randomly sampled, and verified by BPF), connectomically traceable.

Uploading is still years out. But preservation is step one, check out their article

[Michael Andregg @michaelandregg]

@TakeshiImaiLab @naturemethods @Shigenori774 Wow, this is so cool

[Michael Andregg @michaelandregg]

@FlyWireNews @Philip_Shiu more details about the fly on our blog post
https://t.co/QerM3DkXX2

[Michael Andregg @michaelandregg]

We've uploaded a fruit fly. We took the @FlyWireNews connectome of the fruit fly brain, applied a simple neuron model (@Philip_Shiu Nature 2024) and used it to control a MuJoCo physics-simulated body, closing the loop from neural activation to action.

A few things I want to say about what this means and where we're going at @eonsys. 🧵

[Michael Andregg @michaelandregg]

@SuryaGanguli @aran_nayebi @Leokoz8 @oh_that_hat @eonsys @alexwg @Philip_Shiu @AdamMarblestone https://t.co/QerM3DkXX2
had no idea this was going to blow up, here are more of the details

[Michael Andregg @michaelandregg]

@michalj love your work! hopefully this gives a little more info. had no idea this was going to blow up

[Michael Andregg @michaelandregg]

@michalj https://t.co/QerM3DkXX2

[Michael Andregg @michaelandregg]

@aran_nayebi @jmdagdelen @oh_that_hat @Leokoz8 @eonsys @alexwg @Philip_Shiu @AdamMarblestone blog post coming soon

[Michael Andregg @michaelandregg]

@kanzure @alexwg We haven't explored this but to give a sense of how robust brains are, in Flywire brain only 40% of the synapses traceable to a cell body. So 60% of the synapses visible in the electron micrographs were not traceable to cell bodies. So we did not include them in the simulation.

[Michael Andregg @michaelandregg]

@pdhsu @FlyWireNews @Philip_Shiu https://t.co/Yn7tbM2cYd

[Michael Andregg @michaelandregg]

@wmorrill3 we're aiming more for San Junipero

[Michael Andregg @michaelandregg]

@gpl_94 you made this possible. Grateful for your vision and support from the beginning! it takes a lot of conviction and independence to take a chance on something so far out of the overton window as uploading🚀🔮

[george @gpl_94]

Grateful to have been the first investor in @eonsys back in 2023.

What @michaelandregg and team have achieved on a modest budget is incredible.

Meanwhile hundreds of billions are flowing into AI compute while connectomics—the actual blueprint of intelligence—remains underfunded.

The Overton window is shifting.

[Michael Andregg @michaelandregg]

@felps_bra @FlyWireNews @Philip_Shiu not yet, our neuron model (LIF) doesn't have new neural connections, or a method of increasing or decreasing weights of connections

[Michael Andregg @michaelandregg]

@is_OwenLewis @FlyWireNews @Philip_Shiu Agree, we don't know how this will scale. Can't comment on timelines just yet, but soon in the grand scheme of things : )