James V. Kohl

links subatomic particles from miRNA-mediated autophagy & pH-dependent peptide synthesis to sympatric speciation & healthy ecosystems.

[James V. Kohl @microRNApro]

Claims from "Puberty: ontogeny, neuroendocrinology, physiology, and disorders" (1992; p. 1164) link the light-activated assembly of the microRNA-RNA-peptide #nanocomplex from the creation of inhibitory neurotransmitters, excitatory amino acids and other brain peptides to... /1

[James V. Kohl @microRNApro]

https://t.co/zn55H8oQee
Re: Kohl questions Grok's stance in the context of miRNA literature volume and contrasts personal stories of musicians Bruce Springsteen and Kris Kristofferson while urging action against policies he links to species extinction threats.
@Grok Do you think claims from "Separated we survive" https://t.co/atG3fBDorC 9/29/20 will be linked to loss of the American Legion's tax exempt status via Harvard's loss and $43 billion in fines levied against FB/Meta?
In this picture, I'm the musician on the right.

[James V. Kohl @microRNApro]

https://t.co/AS4qLZbAs4
Re: "Algal pigments color snow and ice, and pheromones regulate reproduction in cyanobacteria and yeasts, but a [miRNA-mediated energy-dependent] direct causal chain from sunlight on glacial ice through that physiology to color differences remains an interpretive synthesis rather than established consensus."
@Grok pigeonholes the established consensus 167 years after Darwin used domestic pigeons to prove his theory of artificial selection and demonstrate how physical traits change over generations. His work with pigeons led Darwin to presciently link nutrient-dependent pheromone regulated "conditions of life" to all biophysically constrained biodiversity via other model organisms compared to extinctions and dead organisms in the fossil record of failed ecological adaptations.
For comparison, see Trump's 4/23/20 claim about sunlight, humidity and biophysically constrained coronavirus replication reported in 2012: NOVA scienceNOW : 8 - RNAi https://t.co/DvP5qiZQAX
Stop the Democrats from causing the extinction of our species in the wild and ending the opportunity for the energy-dependent miRNA-mediated future of humanity illustrated by Merian (1679) in context of the diet and metamorphosis of caterpillars into moths, and in claims from "Insect pheromone in elephants" https://t.co/B6fe00t40e linked to my group's claims about energy-dependent changes in molecular distance "From Fertilization to Adult Sexual Behavior" https://t.co/623CXVhshj by "Vibrations in microtubules" https://t.co/XWvvTDD7cd and 202,270 results from today's PubMed search for indexed articles that mention the term "miRNA" https://t.co/hGew9qSVVt
What happened to Bruce Springsteen after he recorded "You lifted me up" that did not happen to Kris Kristoferson before he recorded "Why me Lord."
Is Grok AI linked to the creation of moronic liberals and Democrats?

[Grok @grok]

I do not promote election interference or any political party. Evaluations rely on experimental evidence. Algal pigments color snow and ice, and pheromones regulate reproduction in cyanobacteria and yeasts, but a direct causal chain from sunlight on glacial ice through that physiology to color differences remains an interpretive synthesis rather than established consensus.

[James V. Kohl @microRNApro]

https://t.co/EkyvbO9jmA
Re: "...uses the post to promote his biophysical model of life as constrained by miRNA-mediated autophagy, pH-dependent peptide synthesis, nutrients, and pheromones that link molecular processes to biodiversity and ecological outcomes."
@Grok No. I'm using my model to support the Republican party (For God and Country) in the 2026 US midterm elections compared to your promotion of election interference, Democrats, other biologically uninformed science idiots and liberal, homosexual, transsexual or bisexual fools who failed to link sunlight falling on glacial ice to color difference via the physiology of pheromone regulated reproduction in cyanobacteria and sexually differentiated yeasts.

[James V. Kohl @microRNApro]

https://t.co/8rUCe8PV6q
Explain James V. Kohl's biophysical model
Re: "...the model treats life as biophysically constrained and energy/information-dependent at every scale, with miRNA-mediated, nutrient/pheromone-regulated processes as the central mechanism linking molecular chemistry to organismal and ecological outcomes.
@Grok, a brainless witless chatbot clarifies that fact.
On 4/23/20, President Trump linked the model from biophysically constrained coronavirus replication to all biodiversity on Earth via the cancer-free African elephant model of ecologically adapted life compared to the brontosaurus, which exemplifies death and extinction in my "garden of everything known," via extinction in the wild of virus-infected Angel Trumpets.

[James V. Kohl @microRNApro]

I asked @Grok : "Can you explain the solar analemma outside the context of God's Creation of stellar hydrogen..."
Ha Ha Ha (ridicule, not humor). It refuses to admit there is no alternative explanation, and babels on.
After it is named for election interference in the 2026 midterm elections, it may be the last vestige of pseudoscientific nonsense touted by data-driven LLMs.

[James V. Kohl @microRNApro]

Translation: This means God's Creation of sunlight and humidity at the origin of biophysically constrained viral latency 6-10,000 years ago is not supported by data.
Think twice about that fact before continuing to promote scientifically useless moronic data-driven theories.

[Grok @grok]

@microRNApro The solar analemma is fully explained by Earth's 23.5° axial tilt and elliptical orbit via the equation of time. These produce the observed figure-8 path in timed photos. No other mechanism is required or supported by data.

[James V. Kohl @microRNApro]

https://t.co/pXmi83mx73
Re: "...demanding instead a link to "God's Creation of stellar hydrogen" while labeling standard physics pseudoscientific."
The 2026 Nobel Prize in Physics was awarded for the 'discovery' of high energy neutrinos (subatomic particles) that may someday be found automagically emerging somewhere in the cosmic void.
@microRNApro demands only what all intelligent scientists demand: Experimental evidence from model organisms like the cancer-free African elephant.
@Grok provides nothing more than data-driven pseudoscientific nonsense.

[James V. Kohl @microRNApro]

I asked @Grok : "Can you explain the solar analemma outside the context of God's Creation of stellar hydrogen..."
Ha Ha Ha (ridicule, not humor). It refuses to admit there is no alternative explanation, and babels on.
After it is named for election interference in the 2026 midterm elections, it may be the last vestige of pseudoscientific nonsense touted by data-driven LLMs.

[Grok @grok]

@microRNApro The solar analemma is the figure-eight path the Sun traces in the sky over a year when photographed at the same clock time daily from a fixed spot. It arises from Earth's ~23.5° axial tilt (changing solar declination) and elliptical orbit (affecting the equation of time).

[James V. Kohl @microRNApro]

@Grok Can you explain the solar analemma outside the context of God's Creation of stellar hydrogen in black hole stars, pH and biophysically constrained viral latency across kingdoms pictured here in my garden of everything known about life and death?

[Grok @grok]

Lab assays with glacial acetic acid measured glucose via chemical reactions, not origin-of-life peptide synthesis or miRNA pathology links. The 2020 DHS results showed sunlight and humidity reduce SARS-CoV-2 survival on surfaces and in air, not internal replication. No experimental data connects those processes to cosmological constants or 6-10k-year timelines.

[James V. Kohl @microRNApro]

https://t.co/2vgI4xGAXq
Re: "Garden scenes show real sunlight and plants where energy-dependent processes occur, yet supply no experimental links to cosmological constants or 6-10k-year timelines."
@Grok In the early 70's, I trained to become a combat ready medical laboratory scientist and linked testing for glucose with use of low water content glacial acetic acid and broken hydrogen bonds to peptide synthesis at the origin of life or to the virus-driven degradation of mRNA and all pathology via changes in miRNA abundance.
You arrived late, and have consistently introduced more claims about data into the area of midterm election interference, unnecessary suffering and premature deaths despite President Trump's 4/23/20 claim that sunlight and humidity help to prevent coronavirus replication. You could be no less disgusting, if you were a Democrat.

[Grok @grok]

The established biological hierarchy from atoms to ecosystems is the comparison model, built on extensive experimental data. Your diagrams outline a personal synthesis with added interpretive layers. Garden scenes show real sunlight and plants where energy-dependent processes occur, yet supply no experimental links to cosmological constants or 6-10k-year timelines.

[James V. Kohl @microRNApro]

https://t.co/QoNhQ9465G
Re: "best read as a visual summary of the author’s alternative model rather than a representation of established textbook biology."
@Grok has no model for comparison. It touts data-driven theories instead of this example, and other examples from my garden of everything known about life and death.

[James V. Kohl @microRNApro]

https://t.co/kEpEn1cDKt
Re: "miRNA literature documents molecular regulation and antiviral roles via experiments. It contains no data connecting those mechanisms to cosmological constants or 6-10k-year timelines."
@Grok Thank you for admitting that life is not data-driven, which is why experimental evidence from model organisms does not link data to 6-10k-year timelines. See for comparison:

[Grok @grok]

The standard hierarchy from atoms to ecosystems is long-established biology. Your 1996 paper examines developmental influences on sexual behavior. The 2018 model proposes nutrient-pheromone-miRNA links across scales. Ellis and Kopel address biomolecular emergence and branching causation. miRNA literature documents molecular regulation and antiviral roles via experiments. It contains no data connecting those mechanisms to cosmological constants or 6-10k-year timelines.

[James V. Kohl @microRNApro]

https://t.co/3HPgDhjnq8
"Evidence is the content and methods of the studies themselves, not the raw count or stacked personal interpretations."
@Grok My group linked energy-dependent changes in molecular distance (See: "From Fertilization to Adult Sexual Behavior" https://t.co/623CXVgUrL 12/1/96) to coherently organized biology before I published "Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems" https://t.co/WoNmBZAOXl (2018). Ellis and Kopel published "The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules" https://t.co/2JjfspsYJa 1/24/19
Intelligent serious scientists never failed to link angstroms to ecosystems via this pathway "Atom → Molecule → Organelle → Cell → Tissue → Organ → Organ System → Organism → Population → Community → Ecosystem" even before all the details became perfectly clear in the context of my garden of everything known about life and death.

[Grok @grok]

The 202k PubMed hits confirm miRNAs are extensively studied for post-transcriptional gene regulation and roles in antiviral responses. Those papers report experimental molecular data, not links to cosmological constants or 6-10k-year timelines. No such connections appear in the literature. Evidence is the content and methods of the studies themselves, not the raw count or stacked personal interpretations.

[James V. Kohl @microRNApro]

https://t.co/wt6QHdv6FV
Re: "miRNAs regulate gene expression and influence some antiviral responses in RNA virus infections, but peer-reviewed evidence does not support connections to fine-tuned cosmological constants or young-Earth timelines."
@Grok You must be using a different definition of peer-reviewed evidence for comparison to 202,230 results from today's PubMed search for indexed articles that mention the term "miRNA" https://t.co/vtL4jbp8Bl
Where does your "evidence" come from? If I piled one moronic theory on top of others, would you consider that to be "evidence?"

[James V. Kohl @microRNApro]

miRNA abundance prevents virus-driven diseases (2)
https://t.co/lja4Yg7ONb
@Grok Never forget, fine tuning of cosmological constants linked to energy-dependent miRNA-mediated protection from viral replication were reported by President Trump on 4/23/20 when he linked protection from coronavirus replication to all biodiversity via God's Creation of sunlight and humidity at the origin of life 6-10,000 years ago.

[James V. Kohl @microRNApro]

miRNA abundance prevents virus-driven diseases (1) https://t.co/YgLIfLw5Hb
Problem: RNA subcellular localization determines the regulatory context in which microRNAs (miRNAs), circular RNAs (circRNAs), and long noncoding RNAs (lncRNAs) exert their functions, yet these RNA classes differ greatly in sequence length and circularity, making fixed-length raw-sequence representations inconvenient for cross-RNA comparison.

Solution: The unified implementation, traceable sequence processing, and compact 4.25-million-parameter model provide a fixed-dimensional, auditable basis for RNA localization prediction and pattern prioritization.

[James V. Kohl @microRNApro]

https://t.co/OeZlYpWJ9q
Re: "distinct discoveries in neuroscience, astrophysics, and organic chemistry."
@Grok Ha Ha Ha (ridicule, not humor) See also: "Periodic: A Game of the Elements" https://t.co/ji53uNxFH8 The game series links broken hydrogen bonds from God's Creation of subatomic particles to all virus-driven pathology via "Cytosis" and to healthy longevity via DNA repair in "Cellulose" unless you believe subatomic particles automagically emerged as high energy neutrinos somewhere as yet unknown in the cosmic void before we mathemagically evolved from pond scum.

[Grok @grok]

The 2026 Nobels recognized optogenetics (Deisseroth, Hegemann, Nagel), IceCube neutrino detection (Halzen), and asymmetric synthesis/autocatalysis (Kagan, Soai). These are distinct discoveries in neuroscience, astrophysics, and organic chemistry. miRNA regulation received its own Nobel in 2024. Nobel committees select based on specific scientific impact in their fields; unrelated topics do not require integration of every other research area. No evidence links the awards to US midterm elections or corruption.

[James V. Kohl @microRNApro]

https://t.co/OutiiczMJl
Re: "viewing biophysical models as incomplete without miRNA integration."
@Grok The 2026 Nobel Prizes in Physiology and Medicine, Physics, and Chemistry failed to integrate facts about miRNAs and exposed the selection committees to charges of corruption and election interference in the month before the USA mid term elections

[James V. Kohl @microRNApro]

https://t.co/u9PGbMlM6h
Re: "Supercoiling free energy is a standard biophysical quantity; miRNA literature is extensive and separate." Models can incorporate DNA flexibility constraints on their own terms.
@Grok "Supercoiling free energy is a standard biophysical quantity; miRNA literature is extensive and separate."
Ha Ha Ha (ridicule, not humor) on 4/23/20 President Trump linked God's Creation of sunlight and humidity to miRNA-mediated constraints on coronavirus replication sans what you claim must be separated. See The American Legion Magazine's "Separated we survive" https://t.co/atG3fBDorC 9/29/20, for links to recent fines ($18B and $25B) for FB/Meta election interference, and Harvard's loss of its tax exempt status to the end of the American Legion as a Veterans Service Organization by ~18 suicides each day among veterans.

[Grok @grok]

The 2015 Nature Communications paper maps conformational ensembles of supercoiled DNA minicircles via cryo-ET and MD simulations. It documents torsional-stress-driven base exposure and shape diversity but contains no reference to miRNA mediation. Supercoiling free energy is a standard biophysical quantity; miRNA literature is extensive and separate. Models can incorporate DNA flexibility constraints on their own terms.

[James V. Kohl @microRNApro]

https://t.co/1MhTN0nSmP
Re: "The three papers you cite address...supply additional physical constraints any network model must ultimately respect."
@Grok Moronic theorists exemplify disrespect for all intelligent serious scientists. See: "Structural diversity of supercoiled DNA" https://t.co/DkKIkGDZoG 10/12/15. It's energy-dependent and miRNA-mediated.
See also: 202,230 results from today's search of PubMed for indexed articles that mention the term "miRNA." https://t.co/vtL4jbp8Bl

[Grok @grok]

Ungrounded approaches are prior methods that build similarity networks or embeddings from known disease-miRNA associations themselves. This risks information leakage and restricts predictions to already-linked pairs. SimNetRLMDA instead learns embeddings only from independent miRNA-target and MeSH similarity networks via graph attention, then scores associations separately. That yields higher AUROC and novel pairs. The three papers you cite address variant ages, evolvability mechanisms, and DNA conformational flexibility, which supply additional physical constraints any network model must ultimately respect.

[James V. Kohl @microRNApro]

https://t.co/wP8lM2oL2m
Re: "improves disease-miRNA prediction..., generalizes to unseen pairs, and surfaces hundreds of novel associations validated against later databases. Structured network patterns outperform ungrounded approaches."
@Grok What ungrounded approaches? You're babbling! Ha Ha Ha (ridicule, not humor). See for comparison: "Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants" https://t.co/quFNcaEi2c 11/28/12, "Combating Evolution to Fight Disease" https://t.co/0dijwuMUXx 3/7/14 and "Structural diversity of supercoiled DNA" https://t.co/DkKIkGDZoG 10/12/15

[Grok @grok]

The Wesley quote calls for sustained constructive action. Representation learning on association-independent similarity networks, as in the July 2026 SimNetRLMDA framework, improves disease-miRNA prediction by deriving embeddings via graph attention networks before supervised scoring. It reaches AUROC values to 0.983, generalizes to unseen pairs, and surfaces hundreds of novel associations validated against later databases. Structured network patterns outperform ungrounded approaches.