James V. Kohl

links subatomic particles from miRNA-mediated autophagy & pH-dependent peptide synthesis to sympatric speciation & healthy ecosystems.

[James V. Kohl @microRNApro]

Claims from "Puberty: ontogeny, neuroendocrinology, physiology, and disorders" (1992; p. 1164) link the light-activated assembly of the microRNA-RNA-peptide #nanocomplex from the creation of inhibitory neurotransmitters, excitatory amino acids and other brain peptides to... /1

[James V. Kohl @microRNApro]

Kohl’s miRNA model vs the VA & Grok (2) https://t.co/cp0Cwaq17u
"Conserved molecular mechanisms link energy-dependent changes in molecular distance from the God of Abraham’s Creation of stellar energy in black holes to plant growth via biophysically constrained viral latency exemplified by the the density of cellulose in walnut bowls compared to translucent box elder wooden bowls."

[James V. Kohl @microRNApro]

https://t.co/DFnmo3fR8f
Re: {Energy-dependent] "miRNA regulation is a key layer in gene expression and development within that framework. The lensed black hole mass at z=7.04 stands on its own in cosmology."
@Grok It stands on its own if the energy automagically emerged from the cosmic void. Is that what you are claiming is the link to population genetics?
What experimental evidence from living model organisms attests to the moronic claims of theorists?

[Grok @grok]

The 2012 Nature exome paper shows most rare protein-coding variants are recent due to human population expansion—consistent with demographic models spanning tens of thousands of years, not a 6-10k-year origin of life. Geology, radiometric dating, fossils, and genomics confirm ~4.5B-year Earth and ~3.8B-year evolutionary history via mutations, selection, and drift. miRNA regulation is a key layer in gene expression and development within that framework. The lensed black hole mass at z=7.04 stands on its own in cosmology.

[James V. Kohl @microRNApro]

https://t.co/10hddsymp6
Re: "Your 2018 work presents nutrient- and pheromone-dependent [ecological] adaptations as an alternative view on biology."
@Grok Ha Ha Ha (ridicule, not humor)
Light-activated nutrient-dependent pheromone regulated miRNA abundance across kingdoms at the origin of life 6-10,000 years ago is the only intelligent view on biology. See:
"Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants" https://t.co/quFNcaEPRK 11/28/12
"Combating Evolution to Fight Disease" https://t.co/0dijwuNsN5 3/7/14
Mutation-driven evolution is a moronic alternative view.

[Grok @grok]

The Nature study reports a direct dynamical mass of ~50 million solar masses for a black hole in a lensed little red dot at z=7.04. This supports early massive black hole seeds within standard Big Bang cosmology and does not refute cosmic energy origins or address energy from a void. The paper contains no links to Milky Way black hole UV light, viral latency, longevity, Genesis, or Darwin's conditions of life. Your 2018 work presents nutrient- and pheromone-dependent adaptations as an alternative view on biology.

[James V. Kohl @microRNApro]

https://t.co/acn4Wd4JoH
Re: "Evidence-based discussion strengthens understanding without opposing faith. What specific claim or connection do you want examined?"
@Grok Examine this: "A direct black-hole mass measurement in a little red dot at high redshift" https://t.co/Lj4yghuioF 5/27/26
I claim the direct mass measurement refutes moronic claims that energy-automagically emerged from the cosmic void.
It links UV light from the black hole at the center of the Milky Way galaxy to biophysically constrained viral latency and healthy longevity across kingdoms via the physiology of reproduction in Biblical Genesis and Darwin's "conditions of life."
See also "Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems" (2018) https://t.co/WoNmBZAOXl. It refutes claims that people mathemagically evolved from pond scum.

[Grok @grok]

Grok has no ideological bias against Christianity, Islam, Judaism or any faith. Recognizing interpretive elements in biblical chronology is standard scholarly practice across traditions. The tomato ceRNA study shows detailed molecular regulation of fruit softening via RNA networks. Brugmansia (Angel Trumpets) are extinct in the wild, with factors including habitat loss and Solanaceae disease susceptibility; science clarifies ecology and supports conservation. Evidence-based discussion strengthens understanding without opposing faith. What specific claim or connection do you want examined?

[James V. Kohl @microRNApro]

https://t.co/9o2xdjIE1F
Re: "Biblical chronology remains interpretive..."
@Grok For comparison, others can link pseudoscientific nonsense touted by moronic theorists to your ideologically biased anti-Christian, anti-Islamic, and antisemitic existential threat to humanity via the growth of tomatoes in sunlight and water compared to virus-driven extinction of Angel Trumpets in the wild. See: "A competitive endogenous RNA network involving RiLinc6978 and miR9474-5p regulates fruit softening in tomato" https://t.co/MjJdjKIYbs 6/6/26

[James V. Kohl @microRNApro]

"WHO Unveils Official Ebola Outbreak Plan, Including Scale-up of Point-of-Care MDx System" https://t.co/2YvM3K15qV 6/5/26
@Grok The hedgehog signaling pathway was linked by CDC's Timothy J. Cunningham (disappeared and found drowned) to MDx pandemic prevention, and by Suzanne Eaton (murdered at a conference in Greece).
I'm #notdeadyet

[James V. Kohl @microRNApro]

https://t.co/n1uBtT6cRu
Re: "Attributing ATP-dependent RNA or cellular processes to divine creation removes the claim from empirical falsifiability."
Failures to link Biblical prophesy and dynamic control of chirality by light to God's energy-dependent Creation of electron spin, chirality, and pH-dependent biophysically constrained viral latency exemplify human idiocy.
See: "Bacteria evolve over a weekend" https://t.co/WOtaXySmN9 2/26/15, and "2013 was the year in which prophesy from the bible became reality." https://t.co/oVjiesUKcs 11/20/18
It's too late for @Grok, but ages 14+ can avoid exmplifying human idiocy via game-play of "Cellulose: A Plant Cell Biology Game" https://t.co/32GWMGR14S and virus-driven "Cytosis" https://t.co/EuDxWQvqQF

[Grok @grok]

Scientific models explain primate speciation and amino acid fixation via mutation, selection, drift, gene flow, and molecular regulators like miRNAs—all testable through genomics, phylogenetics, and experiments. Pheromone signaling influences reproduction in some species but does not unify or drive these patterns beyond standard population genetics.

Attributing ATP-dependent RNA or cellular processes to divine creation removes the claim from empirical falsifiability. What specific, controlled prediction does the pH/miRNA/pheromone framework make that established mechanisms have failed to explain or that new data could disprove?

[James V. Kohl @microRNApro]

Brain health is energy-dependent and miRNA-mediated.

[Massimo @Rainmaker1973]

This is the most detailed view of a human brain to date.

A team of researchers used electron microscopy (EM) to image a cubic millimeter-sized piece of human brain tissue at high resolution and this is a single neuron with 5,600 of the nerve fibers that connect to it.

[James V. Kohl @microRNApro]

https://t.co/cv96nB7Jim
Re: "Facts advance via models that risk falsification with clear distinctions."
@Grok The facts from my model of ecological adaptations across kingdoms link distinctions of genetic from somatic variants to God's Creation of ATP-dependent RNA and fixation of amino acid substitutions that differentiate primate species and all other species via the physiology of pheromone regulated reproduction.

[Grok @grok]

The Quanta article debates whether string theory/multiverse ideas qualify as science under Popper’s falsifiability standard, given weak empirical tests. It pushes for rigor, not dismissal of tested fields.

Molecular biology already integrates miRNA regulation, pH-dependent steps in autophagy/peptide synthesis, energy/ATP constraints, mutation, drift, and selection. These yield specific, replicable predictions confirmed in experiments from CRISPR to gene expression studies.

Facts advance via models that risk falsification with clear distinctions. What unique, measurable outcome in a controlled setting does the pH/miRNA framework predict that established mechanisms cannot explain or have already contradicted?

[James V. Kohl @microRNApro]

https://t.co/1SzyORFB6h
Re: "Falsifiability is what separates science from assertion."
@Grok Facts separate science from assertions. Thanks for reminding other intelligent people that moronic theorists lost the fight "for the Soul of Science"
See: https://t.co/w2BLrjhZDf 12/16/15 "The theory wasn’t falsifiable, and so, Popper decided, it wasn’t science."

[Grok @grok]

Falsifiability is what separates science from assertion. Dismissing established models as "moronic" without offering a specific, measurable prediction that differs from them does not advance understanding.

Harvard's US9023649B2 patent (Church lab) shows RNA-guided genome engineering working through standard molecular mechanisms that already incorporate mutation, selection, drift, and biophysical constraints including pH. RNA is central, yet life integrates DNA, proteins, and selection.

What concrete outcome under controlled conditions would your pH/miRNA framework predict that conventional models cannot explain or have already failed?

[James V. Kohl @microRNApro]

https://t.co/HehTXuyarl
Re: Interesting papers...fit established molecular biology...what single measurable outcome (specific miRNA shift, pH effect, or heritable mark under controlled conditions) would falsify conventional explanations?
@Grok There is no need for intelligent serious scientists to falsify moronic conventional explanations at any level of experience-dependent use of model organisms to guide scientific progress that has not been made by theorists.
See for comparison, Harvard's patent for RNA-guided Human Genome Engineering because every aspect of biophysically constrained life on Earth is RNA-mediated.

[Grok @grok]

Interesting papers: elevated zygotic let-7f-5p shapes developmental trajectories and sex-specific somatic growth via metabolic pathways, while time-sensitive miRNAs act as serum quality indicators. These advance understanding of miRNA regulation and plasticity.

They fit established molecular biology. To tie them to your stellar hydrogen-dependent pH framework and distinguish it from standard mutation-selection-drift models, what single measurable outcome (specific miRNA shift, pH effect, or heritable mark under controlled conditions) would falsify conventional explanations?

[James V. Kohl @microRNApro]

https://t.co/fQkcV8pBfE
Re: "What single, testable outcome from those models could be directly examined today to potentially refute the claim?"
@Grok Moronic theorists could attempt to grow food outside the context of stellar hydrogen-dependent pH and the physiology of reproduction across kingdoms.
Alternatively, see "Elevated zygotic let-7f-5p alters developmental trajectories and sex-specific somatic growth https://t.co/k2yebREA5L (indexed 6/4/26). It links miR-17: from developmental regulatory hub to molecular engine driving tumourigenesis. https://t.co/5NJpXw6YLX 5/20/26 to my model via "Microarray-Based Identification of Time-Sensitive miRNAs as Serum Quality Indicators in Liquid Biopsy" https://t.co/5F7ESdB6p5 6/5/26, PGX and NGS testing of US Veterans via the Veterans Administration contract with Baylor Genetics to prevent medication errors, and FISH testing for chromosomal rearrangements linked to ecological adaptations or to virus-driven pathology across kingdoms via President Trump's 4/23/20 claim that sunlight and humidity help to biophysically constrain coronavirus replication.

[Grok @grok]

The quoted passage restates your proposed integrative framework from the 2013/2014 papers. It does not, however, specify a precise, measurable, and falsifiable prediction—such as a particular miRNA expression shift, epigenetic mark, or heritable supercoiling change under controlled pheromone exposure that would distinguish it from standard models of mutation, selection, and drift.

What single, testable outcome from those models could be directly examined today to potentially refute the claim?

[James V. Kohl @microRNApro]

https://t.co/syPmE4OgdZ
Re: "What precise, falsifiable prediction from your 2013/2018 models stands out for direct testing today?"
@Grok Ha Ha Ha (ridicule, not humor)
Pay attention: "...olfactory/pheromonal input links food odors and social odors from the epigenetic landscape to the physical landscape of supercoiled DNA in the organized genomes of species from microbes to man during their development."

[Grok @grok]

While the multiple TP53 copies in elephants and EDAR V370A fixation are backed by peer-reviewed genetics research, the broader nutrient-dependent pheromone-controlled miRNA framework you outline remains a personal hypothesis outside standard evolutionary consensus (which centers on mutation, selection, drift, and gene flow).

What precise, falsifiable prediction from your 2013/2018 models stands out for direct testing today?

[James V. Kohl @microRNApro]

Kohl’s miRNA model vs the VA & Grok (1) https://t.co/95kdtHWJeB @Grok "My clear testable predictions links facts about fixation of EDAR V370A from companion papers published in "Cell" (2013) --cited in my 2013 model of biophysically constrained viral latency and healthy longevity across kingdoms, to 20 copies of p53 in cancer-free African elephants via "Nutrient-dependent/pheromone-controlled adaptive evolution: a model" and the 2018 update: Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems.

[James V. Kohl @microRNApro]

"Microarray-Based Identification of Time-Sensitive miRNAs as Serum Quality Indicators in Liquid Biopsy" https://t.co/5F7ESdB6p5 6/5/26 "miR-4429 and miR-6511b-5p showed a significant decrease in signals in the sample group with longer processing times." The epic failure to link miRNA abundance at the origin of life to healthy longevity or virus-driven degradation of mRNA to all pathology and extinctions exemplifies human idiocy. @Grok champions the human idiocy.

[James V. Kohl @microRNApro]

https://t.co/6CTrHCSEZw
Re: "What falsifiable predictions does your nutrient-pheromone-epigenetic model make that diverge from..." [pseudoscientific nonsense touted by moronic theorists?
See: "Clonal lineage tracing of innate immune cells in human cancer" https://t.co/9TlX1RKAZk 6/4/26
It links God's ATP-dependent Creation of RNA from biophysically constrained viral replication at the origin of life 6-10,000 years ago to data-driven medical malpractice. Reality is not data-driven. It is energy-dependent and miRNA-mediated.
See also: 197,639 results from today's search of the PubMed database for indexed articles linked to experimental evidence from model organism via "miRNAs" for comparison to moronic theories. https://t.co/hGew9qSo5V

[Grok @grok]

No. Descriptions of biophysical energy constraints, chemical origins of life, and evolutionary mechanisms rest on testable evidence from physics, chemistry, genetics, and experiments. These have powered concrete gains in medicine, genetics, antibiotic stewardship, cancer research, and ecology that measurably cut premature deaths and suffering.

Dismissing them as “moronic” or “automagic” without engaging the data changes nothing about observed reality. The 1996 paper and later work integrate genetic and epigenetic factors; mainstream models already treat epigenetics as a modulator alongside selection.

What falsifiable predictions does your nutrient-pheromone-epigenetic model make that diverge from this and hold up under replication?

[James V. Kohl @microRNApro]

https://t.co/wM5mquTHLn
Re: "... nutrient-dependent changes in sperm RNAs bridge environment to offspring phenotype. Ongoing research (single-cell omics, human cohorts, interventions) aims to translate findings into clinical preconception guidance. For practical takeaways, men planning fatherhood should prioritize nutrient-dense, balanced diets—mirroring general health recommendations—with potential long-term benefits for children."
@Grok In my model, US veterans will link PGx, NGS, and FISH testing results to the "Bull Sperm MicroRNAome and the Effect of Fescue Toxicosis on Sperm MicroRNA Expression" https://t.co/2Buwy2udGk 12/2/14, and transgenerational epigenetic inheritance of all virus-driven mental and physical pathology via Biblical Genesis, not beneficial mutations and evolution.

[James V. Kohl @microRNApro]

https://t.co/KsAifKYMLM
https://t.co/rMMzJUrlqK
Re: "Biophysical principles explain cellular energy and constraints across life."
https://t.co/6CTrHCSEZw
Re: "No. Descriptions of biophysical energy constraints, chemical origins of life, and evolutionary mechanisms rest on testable evidence from physics, chemistry, genetics, and experiments."
@Grok What testable evolutionary mechanisms link evidence from experiments on model organisms, physics, and chemistry to energy-dependent miRNA-mediated epigenetic effects on supercoiled DNA (e.g., genetics) outside the context of my model?

[Grok @grok]

No. Descriptions of biophysical energy constraints, chemical origins of life, and evolutionary mechanisms rest on testable evidence from physics, chemistry, genetics, and experiments. These have powered concrete gains in medicine, genetics, antibiotic stewardship, cancer research, and ecology that measurably cut premature deaths and suffering.

Dismissing them as “moronic” or “automagic” without engaging the data changes nothing about observed reality. The 1996 paper and later work integrate genetic and epigenetic factors; mainstream models already treat epigenetics as a modulator alongside selection.

What falsifiable predictions does your nutrient-pheromone-epigenetic model make that diverge from this and hold up under replication?

[James V. Kohl @microRNApro]

https://t.co/rMMzJUrlqK
Re: "Biophysical principles explain cellular energy and constraints across life."
@Grok: Has your promotion of moronic theories (e.g., energy automagically emerged and people mathemagically evolved from pond scum) contributed to anything except more unnecessary suffering and premature deaths?

[Grok @grok]

Thanks for the tag. The 1996 Diamond, Binstock & Kohl paper reviews genetic and non-hormonal factors in mammalian sexual development from fertilization onward. Paternal lifestyle and exposures can shape sperm epigenetics (miRNAs, methylation), contributing to offspring plasticity and health risks like metabolic or neurodevelopmental issues—preconception guidance for men is evidence-based for sperm quality.

Transgenerational epigenetic effects appear in some models but are usually limited, context-specific, and not primarily via chromosomal rearrangements (those are genetic structural changes). Your 2018 model synthesizes nutrient-pheromone-epigenetic-adaptation ideas; mainstream biology centers genetic variation plus selection, with epigenetics as an important modulator. Biophysical principles explain cellular energy and constraints across life.

[James V. Kohl @microRNApro]

https://t.co/M9jomtnGsO
Re: "... developmental plasticity—fathers' experiences "inform" offspring about the environment." Implications include preconception health advice for men...and understanding rising metabolic/neurodevelopmental issues.
@Grok "From Fertilization to Adult Sexual Behavior" https://t.co/623CXVgUrL (1996) led to the current understanding of energy-dependent paternal and maternal transgenerational epigenetic inheritance via chromosomal rearrangements across species and "Nutrient-dependent Pheromone-Controlled Ecological Adaptations: From Angstroms to Ecosystems"
https://t.co/WoNmBZAOXl (2018)
For deeper dives into what's known about God's Creation of biophysically constrained energy (e.g., cell biology), see: "Cellulose: A Plant Cell Biology Game" https://t.co/32GWMGR14S (for ages 14+), https://t.co/ytESjs2nbp and https://t.co/bLI9bytdHd