Distal rectal polyp - HPV-associated glandular neoplasms are rare and mimic tubulovillous adenomas. The mucin is peculiar and apical apoptotic bodies can be plentiful (arrow).
Voltaggio L, et al. Mod Pathol. 2020 May;33(5):944-952. PMID: 31857682.
Another spectacular EBV-associated gastric carcinoma (gastric carcinoma with lymphoid stroma). This example has overt gland formation and more sheet-like areas.
This week, I learned not only that gangliocytic paragangliomas were reclassified by the WHO as composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET) - thank you Rhonda Yantiss - but also that they can express CD117/KIT to result in wrong diagnoses on small biopsies.
Inflammatory fibroid polyp is a neoplasm with PDGFRA mutations. Small bowel examples tend to present with intussusception. Mitoses (arrow) are infrequent. Gastric examples are usually antral and some have giant cells. The background eosinophils are typical. #UmiamiPath
Gastric fundic gland polyps and a foveolar adenoma from a patient with gastric adenocarcinoma proximal polyposis syndrome (GAPPS), a variant of familial adenomatous polyposis. Because the APC gene is large, the mutation was not detected until 2016. #umiamipath
PMID: 27087319
Colonic ganglioneuromas are often a component of the polyposis in patients with the PTEN hamartoma (Cowden) syndrome. These patients have skin lesions (facial trichilemmoma, acral keratoses, papillomatous papules) can develop malignancies (esp. of breast, thyroid). #umiamipath
How well do you know your variants of colon cancer? π€π¬ The WHO π has its list of recognized variants, but do you know which ones are important, which are no longer recognized, and which have been discarded? π«π‘ Dive into the details and stay informed! https://t.co/8EUSPnspQt
β³οΈThis is an awesome review
β³οΈAll the evidence you were looking for.
β³οΈThe most comprehesive review I have read!
Norton EJ, Bateman AC. Risk assessment in pT1 colorectal cancer. J Clin Pathol. 2023 Nov 24:jcp-2023-208803.
https://t.co/6hmUWcOUWS
I posted my notes on Respiratory cytology, including the new IAC-IARC-WHO system, to my teaching website, "Kurt's Notes" (https://t.co/OKmaPvGQpJ).
π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π« π«
Full notes available here: https://t.co/2VbnXnLocV
I just updated my Thyroid Cytology notes on my teaching website, "Kurt's Notes" (https://t.co/OKmaPvGQpJ) to incorporate the newest Bethesda system.
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Full notes available here: https://t.co/dySy8TY6R1