Michael McLean

Research Engineer at @structurabio | Engineering Physics graduate from @UofT | he/him

[Michael McLean @mklmclean]

@00aleph00 Mind boggling!

[Merriam-Webster @MerriamWebster]

Merriam-Webster’s human editors have chosen ‘slop’ as the 2025 Word of the Year.

[Structura Biotechnology @structurabio]

On a gruelling hunt for rare associated molecules in your #cryoEM particle stack and not sure where to look?

Discover practical tips and tricks in our new case study using #CryoSPARC v4.7.1 where we find and refine a low-population interaction partner!

https://t.co/O38hK0KmjZ

[Structura Biotechnology @structurabio]

🚀Introducing fully automated data processing for repeat-target #cryoEM.

Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention.

Preprint: https://t.co/pt9aRc8p5L

[miro astore @miroastore]

That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
https://t.co/5mmJOSHjs1

[adithya @00aleph00]

What is a manifold? A brief, intuitive explanation:

[Structura Biotechnology @structurabio]

1/ CryoSPARC v4.5 is here! 🚀

Updates include a new micrograph denoiser, automatic 2D/3D class selection, direct file upload, new orientation diagnostics, improvements to Workflows, 3D classification, motion correction, volume alignment, and more!
https://t.co/M3mLGtFhSS

[Structura Biotechnology @structurabio]

Using #CryoSPARC 3D Flexible Refinement to explore continuous heterogeneity in your #cryoEM data?

Check out a new in-depth guide and video on preparing custom tetrahedral meshes that can improve 3D Flex results, plus potential pitfalls to avoid: https://t.co/v3AsTOCGQv

[Structura Biotechnology @structurabio]

Working on getting from 2D to 3D with #cryoEM data?

Check out our newly updated #CryoSPARC guide page on Ab-Initio Reconstruction, with expanded algorithm descriptions, figures, and details about important parameters!

https://t.co/3S0qO9JSOB

[Structura Biotechnology @structurabio]

Working on local refinement in #cryoEM?

Check out our fully updated #CryoSPARC guide pages, featuring helpful theory notes, commonly adjusted parameters, a new video on mask creation methods, and updated case study processing EMPIAR-10073!

https://t.co/QlRFE24Xbj

[Structura Biotechnology @structurabio]

We are looking for a Software Engineer to join the #CryoSPARC team! Join us to work on exciting new #cryoEM software solutions: https://t.co/2kr7yGehD7

[Michael McLean @mklmclean]

@OliBClarke This is really neat to see, thanks for the detailed reports @OliBClarke! Out of curiosity, were you able to use an asymmetric refinement from CryoSPARC as an input volume for HI3D to obtain candidate helical symmetry params?

[Structura Biotechnology @structurabio]

1/ #CryoSPARC v4.4 is here! 🚀
Updates include tools to streamline repeat #cryoEM processing, reference based motion correction, orientation diagnostics, symmetry tools, improved 3DFlex, caching, data cleanup and more!
https://t.co/M3mLGtFPIq

[Structura Biotechnology @structurabio]

We are looking for a Product Engineer to join the #CryoSPARC team! Join us to work on #cryoEM software development focussing on user workflows.

More details and how to apply: https://t.co/idpIBirpRC

[Michael McLean @mklmclean]

@00aleph00 @daviderady 👨‍��‼️‼️ i am so excited omg

[Michael McLean @mklmclean]

@00aleph00 multivariable calculus!!! everything about calculus becomes so cool/different in 2+ dimensions compared to 1, but was taught too quickly and I don’t think I really had enough time to absorb. stokes theorem, coordinate systems/transforms, Jacobians/hessians, grad/div/curl, etc…

[Structura Biotechnology @structurabio]

Interested in working on #cryoEM methods development, data processing, product development and/or education? We have several open positions to work on #CryoSPARC! ❄️⚡
Please share widely 🙂 https://t.co/eGmCU9ZMLq

[Michael McLean @mklmclean]

It was a delight for @suhaildawood and I to present and walk-through #CryoSPARC with everyone! 🔬❄️⚡️

[Michael Cianfrocco @mcianfro]

#cryoEM workshop day 3: #cryoSPARC from @structurabio !

[Michael Cianfrocco @mcianfro]

#cryoEM workshop day 3: #cryoSPARC from @structurabio !

[Structura Biotechnology @structurabio]

📄 An updated paper describing 3D Flexible Refinement is now out in @naturemethods!
Paper: https://t.co/sCn0nVmcEx

It describes further experimental #cryoEM results and the improved 3DFlex method that was released in #CryoSPARC v4.1 ❄️⚡
Tutorial: https://t.co/ct3QT93W2m