María Muñoz

Building AI models for personalized cancer vaccines

[María Muñoz @mmunozpz]

@Mawuko @invokebio Thanks! We train our own models yes.
Here you have a recent blog post on how we do things:

https://t.co/OXJJwJ0dSF

And it will link you to the recent model preprint we have published. Follow @invokebio for more updates and details! 🚀

[María Muñoz @mmunozpz]

Hello from San Francisco!
Decided it’s finally time to make my first post in x. I’m María Muñoz, AI researcher at @invokebio where we’re building AI models for designing personalized cancer treatments.

I will be posting updates and my projects here. Follow along for the ride 🚀

[María Muñoz @mmunozpz]

@EmiPerezAnsaldi @invokebio @miriamgonp Thank you Emiliano, me and the rest of @invokebio team are already in touch with her.

[María Muñoz @mmunozpz]

Hello, our model predicts which neoantigens (little sequences presented by tumor cells) are the most prone to "invoke" an immune response and we can design personalized cancer vaccines with those. The evaluation for the model is done through several datasets from the field that serve as ground truth of measured response to T cells (immune cells) in the lab. Apart from that @invokebio is actually dosing real patients TODAY, so we also have real outcomes.

You should check our public preprint:

https://t.co/K7Xe0Rk5C6

We have there all the benchmarking with real and open numbers. And follow us for more updates! 🚀

[María Muñoz @mmunozpz]

@iurex @invokebio Lo haré! Sigue también a @invokebio ahí estarán todos los updates pronto.

[María Muñoz @mmunozpz]

@RaduTiciu @invokebio Thank you Radu! It was explosive yes, I’m honored to see it happened. You should follow @invokebio for all our updates 🫡🚀

[María Muñoz @mmunozpz]

@Coinperiscopio @invokebio JAJAJAJAJAJA, para nada, ni yo ni nadie en @invokebio es malvado, podéis dormir tranquilos!

[María Muñoz @mmunozpz]

@bitcoinpendium @invokebio @miriamgonp Hola David, si estamos en contacto ya!

[María Muñoz @mmunozpz]

Hi,

That’s a fair question. In cancer is a bit different, is just the name they have but they are not vaccines given to healthy people to prevent them from cancer.

Personalized cancer vaccines are given when someone is already fighting cancer, after doing a biopsy and sequencing their tumor you can analyze what the tumor is presenting in the surface of its cells (neoantigens), which are unique from patient to patient, and vaccinate the patient with the ones that you think can “invoke” a higher immune response, your immune system will learn it has to attack those and it will fight the cancer itself. You should check @invokebio recent blog to explain our exact approach and results:

https://t.co/7vIUXFWbxz

And interestingly, this immune response has memory, so these vaccines are often given after removing the tumor with surgery to now “prevent” a relapse.

Hope the explanation was easy to follow, happy to answer follow up questions or just DM me 🫡

[María Muñoz @mmunozpz]

@Andrew_Smales @invokebio Thank you Andrew, will do! You should follow also @invokebio we will start sharing updates there soon

[María Muñoz @mmunozpz]

@DontFearAI @invokebio NEMo 🚀
@invokebio ‘s model we have for predicting immunogenicity in neoantigens (what to put in a vaccine for a given so that your own body can fight it)

Check it out: https://t.co/POhBykZ1Qg

[María Muñoz @mmunozpz]

@darmstadiym @invokebio @uc3m Universidad Carlos III de Madrid

[María Muñoz @mmunozpz]

Hi Diego, that’s a really good question. Our model predicts which neoantigens (little sequences presented by tumor cells) are the most prone to "invoke" an immune response and we can design personalized cancer vaccines with those. The evaluation for the model is done through several datasets that serve as benchmarks of measured response to T cells (immune cells) in the lab. Apart from that @invokebio is actually dosing real patients TODAY, so we also have real outcomes.

You should check our public preprint: https://t.co/K7Xe0Rk5C6
We have there all the benchmarking with real and open numbers. And follow us for more updates! 🚀

[María Muñoz @mmunozpz]

@VarunGangal @invokebio Agree, SF has something special

[María Muñoz @mmunozpz]

@kaveenhimash @invokebio Nice to hear that Kaveen, you should follow @invokebio for all the updates 🚀

[María Muñoz @mmunozpz]

@JackFOmni @invokebio thank you Jack, it is an incredible challenge yes, follow @invokebio for updates!

[María Muñoz @mmunozpz]

@generativist @invokebio Hi Johnny!
Thanks for the welcome. Yes, our technology should work also for chordoma. Follow @invokebio for future updates🫡

[María Muñoz @mmunozpz]

@alpas17_ @invokebio

[María Muñoz @mmunozpz]

@KirchukNicolas @invokebio Awesome Nicolas! Let's talk soon

[María Muñoz @mmunozpz]

@GuliMoreno @invokebio @exp8fellowship From Spain to the moon 🇪🇸🔥