Navarro lab

Intracellular Signalling in Inflammatory Processes at @CBMSO_CSIC_UAM. Mad about signalling in T cells of all flavours. Current love interest: interleukin 23

[Navarro lab @mnnavarro_lab]

1/8 New paper from our lab! We identify the Src/Abl inhibitor Dasatinib as a potent suppressor of IL-23 signalling and IL-17 production in skin inflammation.

🧪 Reveals a new IL-23–Src–mTOR axis in type 3 immunity

🔗 https://t.co/RBVKthtI45

@jacionline @CBM_CSIC_UAM

[Mittelbrunn Lab @MMittelbrunn]

🔬 How do ageing T cells compromise intestinal homeostasis & can we reverse it?
With @mmgomezheras, we discuss how ageing T cells compromise gut and what therapeutic strategies could help restore them for healthier longevity.
👉 https://t.co/jkM2UbY2pR
#GutHealth #inflammaging

[Centro de Biología Molecular Severo Ochoa @CBM_CSIC_UAM]

🧬 Un estudio del grupo de María Luisa Toribio @ToribioLab revela que pequeñas moléculas producidas por el organismo podrían ayudar a frenar el crecimiento de la leucemia linfoblástica aguda de células T (LLA-T), uno de los tipos más agresivos de leucemia.
https://t.co/W6N1isknY0

[🏳️‍🌈🏳️‍⚧️Toribio Lab @ToribioLab]

Excited to share that our latest work is nearly out!
We uncover a tumor suppressor role of the miR-15b/16-2 cluster in T-ALL.
Stay tuned! Coming soon in @BloodPortfolio

[Carlos Anerillas @CarlosAnerillas]

Paper out 🎆🎆🎆 Check our latest publication 👇

Here, we propose an emerging role for the extracellular matrix as a driver of senescent cell accumulation during aging 👨‍🦳👵

Hope you guys like it! Open to any feedback/suggestions/critiques 😊
https://t.co/rK2pA54D33

[Mittelbrunn Lab @MMittelbrunn]

🚨 New paper from @MMittelbrunn Lab @CBM_CSIC_UAM
We show that butyrate extends health and lifespan in mouse models of mitochondrial disease — highlighting a powerful link between mitochondrial dysfunction and the gut microbiota

🔗 Read the paper here: https://t.co/euNOZ1xBYL

[IMDEA Nutrición @IMDEANutricion]

3️⃣0️⃣0️⃣ es el número de participantes que necesitamos para el estudio de #celiaquía 🔛

Hemos llegado al ecuador en este reto de mejorar tratamientos y crear soluciones más efectivas.
¿Nos ayudáis a cumplirlo?
🙋🏼‍♂️ https://t.co/w8vW9PmRes

#dietasingluten
#CD3Dtech @ComunidadMadrid

[Navarro lab @mnnavarro_lab]

Fantastic team! Very proud of the PhD students in the lab! Go gd go!

[🏳️‍🌈🏳️‍⚧️Toribio Lab @ToribioLab]

Also @CayuelaIgnacio Lis and Jorge from the @mnnavarro_lab at @CBM_CSIC_UAM talked about how IL-23-driven signalling shapes γδ17 T cell responses in skin inflammation 🧬
Their studies converge on understanding and modulating key pathways in psoriasis and inflammatory disease 💊

[Navarro lab @mnnavarro_lab]

Congratulations Vir!!

[Virginia García de Yébenes Mena @vgyebenes]

Very happy to share our latest lab work published in Leukemia, in which we identify the microRNA miR-28 as an effective inhibitor of ibrutinib resistance in ABC-DLBCL https://t.co/VWQMmts5vv

[Navarro lab @mnnavarro_lab]

@ToribioLab @CBM_CSIC_UAM @jacionline Thanks a lot! And thanks for all the support for this work

[Navarro lab @mnnavarro_lab]

1/8 New paper from our lab! We identify the Src/Abl inhibitor Dasatinib as a potent suppressor of IL-23 signalling and IL-17 production in skin inflammation.

🧪 Reveals a new IL-23–Src–mTOR axis in type 3 immunity

🔗 https://t.co/RBVKthtI45

@jacionline @CBM_CSIC_UAM

[Navarro lab @mnnavarro_lab]

@vgyebenes @jacionline @CBM_CSIC_UAM Thanks a lot Vir!!

[CSIC @CSIC]

💊Un fármaco aprobado para otro uso reduce la inflamación en la psoriasis en un modelo experimental

🔬Un estudio del @CBM_CSIC_UAM identifica un mecanismo desconocido hasta ahora que controla la producción de moléculas inflamatorias en esta enfermedad

➡️ https://t.co/vvvNOJ5EQd

[Navarro lab @mnnavarro_lab]

8/8 Take-home: Targeting Src signalling can suppress IL-23–driven type 3 immunity.

Dasatinib - candidate for drug repurposing in psoriasis and related diseases.
Big thanks to all co-authors & collaborators 🙌 @CayuelaIgnacio @LabTraba

#Psoriasis #Inflammation #Tcells #γδ17

[Navarro lab @mnnavarro_lab]

7/8 We identify the Src kinase Blk as a key player in γδ17 T cells: Loss-of-function experiments show that Blk is required for mTORC1 activation and IL-17 production in response to IL-23.

[Yogesh Kulathu @YKulathu]

Registration now open: 2026 #EMBO #Ubiquitin Workshop set in stunning Monopoli, Puglia 🇮🇹
Cutting edge science, great speakers, short talk opportunities, travel awards
Limited spaces. Dont miss out - register early!
Registration & more info: https://t.co/O29ToXHgoR