Molecular Dimensions

The official Twitter account of Molecular Dimensions

[Molecular Dimensions @molecularD]

Beckham et. al. at EMBL Hamburg used the Molecular Dimensions Morpheus screen to solve the ESX-5 type VII secretion system. The unique combination of flexible protein layers around the pore to allow large conformational plasticity.
DOI: 10.1126/sciadv.abg9923
#structuralbiology

[Molecular Dimensions @molecularD]

Using Molecular Dimensions SelenoMet Medium Complete, Lazaro et. all. from CRNS showed that the mL-GHD180 adopts a unique quaternary structure. The ACT-like and PAS-type domains indicate allosteric regulation. DOI: 10.1038/s42003-021-02222-x

[Molecular Dimensions @molecularD]

A structural basis for the inhibition of malaria cFRS by a novel series of bicyclic azetidines was solved by Shamsa et. al. https://t.co/J3yXqfvT62

Read more here: #CalibreScientific #structurebiology #crystallisation #crystallisation

[Molecular Dimensions @molecularD]

The Schiffer Lab at UMass Medical School are investigating direct acting antivirals including a non-covalent inhibitor ML188.  Using our PACT Premier screen: https://t.co/DcTN63C0lC

Read more about the research: https://t.co/lsGOsx5ix5

#structuralbiology #crystallisation

[Molecular Dimensions @molecularD]

Valle et. al. at UMR crystallised the Ebola methyltransferase domain of the 'large' L protein. Crystals were obtained after a hit on the Molecular Dimensions ProPlex screen. #CalibreScientific #structurebiology #crystallisation #crystallisation #ebola

[Molecular Dimensions @molecularD]

Blum et. al at the Paul Scherrer insititute in Swizerland improved the refinement of protein nanocrystals by statistically correcting the dynamic electron scattering,
read more here: https://t.co/aAffuu34XE

#CalibreScientific #structurebiology #crystallisation #crystallisation

[Molecular Dimensions @molecularD]

Using SelenoMet Base and medium, Abidi et. al. from CBRS examined the Bcs macrocomplex involved in biofilm secretion of pathogenetic enterobacteria.
https://t.co/plGNP3Mi9A

Complete Article Here: https://t.co/tpeL5EiIJ6

#structurebiology #crystallisation #crystallisation

[Molecular Dimensions @molecularD]

Using the Pact premier screen, Kaczmarski et. al. demonstrated that remote mutations can reshape the global confirmation of cyclohexadienyl dehydratase, funnelling it into catalytically relevant conformations.
doi: 10.1038/s41467-020-19695-9
https://t.co/0Knkpm3vF3

[Molecular Dimensions @molecularD]

Cawood et. al. at University of Leeds used Morpheus buffers to stablise oligomers with covalently tethered small molecules using "post-translational chemical modification"
doi: 10.1021/jacs.0c10629

Learn more about our buffer lines here:https://t.co/ayxK6kq1zT

[Molecular Dimensions @molecularD]

Morpheus screens were used to crystallise α-cobratoxin bound with small peptides that inhibit toxicity by Lynagh et. al. at University of Bergen
doi: 10.1021/acs.jmedchem.0c01202

Learn more about the Morpheus family of screens here: https://t.co/IvhTuKMDO0

[Molecular Dimensions @molecularD]

Crystals of the SiaABC domain grown using the @molecularD JCSG+ and Morpheus screens helps researchers to better understand biofilm growth
doi: 10.1371/journal.pone.0241019

Find out more about our screens here: https://t.co/L4AtCGNiMF

[Molecular Dimensions @molecularD]

Researchers at Sheffield crystallised the A component (SmhA) of a tripartite pore-forming toxin using @molecularD Screens: JCSG+, Pact premier, ProPlex and Morpheus
doi: 10.1107/S2053230X20013862
#CalibreScientific

Find out about all our screens here: https://t.co/vFSmVFuqJ4

[Molecular Dimensions @molecularD]

Rattlesnake venom neurotoxin structure investigated and reveal possible interactions with #CFTR found in #CysticFibrosis patients
doi: 10.3390/molecules25225290
#CalibreScientific

Learn about the MemGold used to create the crystal: https://t.co/PsyqL97Fp3

[Molecular Dimensions @molecularD]

Rodnin et. al. from @KUMedCenter examined the structure of Diptheria Toxin with crystal obtained using @molecularD drop crystallisation plates
doi: 10.3390/toxins12110704
#Calibre Scientific

Find all our plates here: https://t.co/eSAZdXABOl

[Molecular Dimensions @molecularD]

Kozak et. al. from @emblderived diffraction quality N-glycosylated proteins from the GlycoDelete HEK293 cell line using the @molecularDMorpheus I screen
doi: 10.1107/S2059798320013753
#CalibreScientific

Find out more about our Morpheus screens here: https://t.co/B8ZFT08Nil

[Molecular Dimensions @molecularD]

Using @molecularDM9 Minimal Media, Manav. et. al at @MRC_LMB investigated the inhibition of an archaeal CRISPR subunit by an anti-CRISPR protein
doi: 10.1038/s41467-020-19847-x

Find out about our media selection here: https://t.co/2SLN8przEZ

[Molecular Dimensions @molecularD]

Using @molecularDSelenoMet medium, colleagues Zhang, Bellini and Barford at the @MRC_LMB solved the crystal structure of Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex
doi: 10.1093/nar/gkaa772

Find more about our SelenoMet here: https://t.co/En8Wnmqk4r

[Molecular Dimensions @molecularD]

Our #CryoEM c-flats were used by Huo et. al. https://t.co/SaySS5Uipp

The paper published in Cell focuses on the destruction of the SARS-CoV-2 spike protein to neutralise the virus. Read more here: https://t.co/67WY9yY6rc

[Molecular Dimensions @molecularD]

Our #CryoEM c-flats were used by Chen et. al. https://t.co/3WhVSlev0l

The Cell article features a unique look into the SARS-CoV-2 Replication Complex https://t.co/etH5J37QJy

[Molecular Dimensions @molecularD]

Using a Morpheus screen: https://t.co/Wucv8yYNmi

Rut etl al Investigated the substrate specificity of SARS-CoV-2. Read more about their work here in their preprint: https://t.co/bmEC5awNOW

#COVID