moligotech

At Moligo Technologies, we enzymatically produce of long and ultra-pure DNA strands at industrial scales.

[Cosimo Ducani @CosimoDucani]

Purity Length Scale. That'show @moligotech 's DNA synthesis platform will make gene technologies and therapies safer, more effective and affordable. If you are interested in knowing how we are going to make kilos of 10 kb ultrapure sssDNA visit our booth at @BuiltWithBio

[moligotech @moligotech]

The comparison between genetic tools available for prokaryotes and even invertebrates such as drosophila has historically vastly outnumbered those for vertebrate models. It is time to redress that balance: https://t.co/OxNd5ZS5dv #molecularbiology #MolecularGenetics

[moligotech @moligotech]

The use of CRISPR in research to understand biological processes and diseases will accelerate research and provide new therapies and diagnostics that might never ultimately be attributed to CRISPR. Check this article to learn more: https://t.co/OxNd5ZS5dv

[moligotech @moligotech]

Which donor template should you choose?
AAVs have some specific and important advantages such as their ability to package and securely deliver up to 5Kb of ssDNA, but if you need longer sequences, we’ve got you covered. https://t.co/cLHN3UKOzd
#DNA #Crispr #science #DNADonor

[moligotech @moligotech]

A publication in Nature Communications showed CRISPR has been used to understand host factors that regulate SARS-CoV-2 entry. It also highlights the speed & scale of CRISPR to advance science at a much faster rate than was previously possible. https://t.co/0qdlM3LayF

[moligotech @moligotech]

An alternative to viral vectors? How about lipids? They can have different chemical properties and are used to form lipoplexes with unique features. https://t.co/QAyWArKEEj #lipids #lipoplexes #dnadelivery

[moligotech @moligotech]

As opposed to microinjection, electroporation is a good technique to use for cell population, it has quite high transfection efficiency & it’s quite easy to use in any standard research laboratory. Read more: https://t.co/QAyWArK6OL #microinjection #Researchlab #Electroporation

[moligotech @moligotech]

Hydrodynamics is probably the technique that better represents the idea of physical delivery methods, since it uses the physical property of the blood as liquid, to deliver the desired cargo in-vivo. https://t.co/QAyWArK6OL #hydrodynamics #moligotechnologies #dnadelivery

[moligotech @moligotech]

Are adeno-associated viruses the safest category of viral vectors? They do not trigger an immune response and they are not known to cause or be related to any human disease. https://t.co/QAyWArK6OL #AAV #moligotechnologies #dnadelivery

[moligotech @moligotech]

In the majority of gene therapies in the current clinical trials or under development, the nucleic acid cargo consists of long DNA molecules which can be present in a variety of forms. https://t.co/QAyWArK6OL #clinicaltrials #clinicaltrialsguru #clinicaltrialsite

[moligotech @moligotech]

AAVs are relatively expensive & time consuming to produce compared to dsDNA and ssDNA. The length of the donor template is also restricted by the packaging capacity of the virus which is less than 5 kb. Learn more: https://t.co/cLHN3UKOzd

[moligotech @moligotech]

Picking the right donor template can significantly affect the outcome of your CRISPR experiments or therapies. Could ssDNA improve your efficiencies? Learn more: https://t.co/cLHN3UKOzd #ssDNA #dsDNA #CRISPRexperiment #DNA

[moligotech @moligotech]

Powerful technology has brought genome editing into the spotlight. It is possible to modify a specific genetic sequence to substitute a defective gene, but how do you get the DNA efficiently into the cells? https://t.co/QAyWAs1HGj #genomeediting #genomeproject #genomesequencing

[moligotech @moligotech]

Picking the right donor template can significantly affect the outcome of your CRISPR experiments or therapies. Moligo is changing the way ssDNA can be used. Find out more here: https://t.co/cLHN3UKOzd

#ssDNA #dsDNA #CRISPRexperiment ##DNA

[moligotech @moligotech]

The main disadvantage of AVs is the strong immune response that they can trigger which can reduce the effectiveness of treatment as well as being dangerous. https://t.co/QAyWArK6OL #adenovirus #dnadelivery #moligotechnologies

[moligotech @moligotech]

The ability to create knockouts that will be much faster to generate new mouse models to study neurons in the future. This will help provide insights from neuronal disease, cognitive processes and modeling emerging technologies on the human nervous system.https://t.co/OxNd5ZS5dv

[moligotech @moligotech]

The comparison between genetic tools available for prokaryotes and even invertebrates such as drosophila has historically vastly outnumbered those for vertebrate models. It is time to redress that balance: https://t.co/OxNd5ZS5dv #molecularbiology #MolecularGenetics

[moligotech @moligotech]

The use of CRISPR in research to understand biological processes and diseases will accelerate research and provide new therapies and diagnostics that might never ultimately be attributed to CRISPR. Check this article to learn more: https://t.co/OxNd5ZS5dv

[moligotech @moligotech]

Which donor template should you choose?
AAVs have some specific and important advantages such as their ability to package and securely deliver up to 5Kb of ssDNA, but if you need longer sequences, we’ve got you covered. https://t.co/cLHN3UKOzd
#DNA #Crispr #science #DNADonor

[moligotech @moligotech]

A publication in Nature Communications showed CRISPR has been used to understand host factors that regulate SARS-CoV-2 entry. It also highlights the speed & scale of CRISPR to advance science at a much faster rate than was previously possible. https://t.co/0qdlM3LayF