mscurefocus

Unlocking the cure to MS, one tweet at a time. What’s the most important thing when trying to #cureMS? Knowing that you can.

[mscurefocus @mscure2020]

Is it ironic or tragic when the next major breakthrough in MS therapy is discovered but not recognized?

[mscurefocus @mscure2020]

@Brandon_Beaber Sure, largely psychological if you ignore local effects of such high doses on stomach mucosa as well as the relatively higher dose exposure to the gut associated lymphoid tissue.

These local effects are unknown at such high exposures and enough of a concern to avoid oral dosing

[mscurefocus @mscure2020]

@Brandon_Beaber MRIs (like low Vitamin D) must cause MS!

[mscurefocus @mscure2020]

@GavinGiovannoni @ProfRobHoward @GreenJournal @HA Do you recognize the echoes of the RIS/CIS/MS debates in these articles?

[mscurefocus @mscure2020]

@Brandon_Beaber Also likely reflects poor terminology. Like Eskimo’s have multiple words for snow we likely need more words for subjective, clinical and objective activity in MS.

[mscurefocus @mscure2020]

@Brandon_Beaber “Although RAM rate decreased with DMTs according to their expected efficacy, ACES rate was stable across DMTs.”

Given no impact of DMTs, it seems more likely that these events are unrelated to underlying inflammatory events and thus perhaps miscategorized as acute relapse.

[mscurefocus @mscure2020]

@neurognanapavan @Florianadea It’s logically obvious that progressive MS starts at the beginning of disease and is not a late feature.

[mscurefocus @mscure2020]

After a COVID mandated pause I’m back tweeting.

What do you the biggest news in MS over the last 2 years has been?

[mscurefocus @mscure2020]

@DrJim4MS @GavinGiovannoni Is there a good review article or source with information about innate immune activity in the setting of MS?

[mscurefocus @mscure2020]

@GavinGiovannoni I think MS is two problems. One is inflammatory in nature, and certainly may have an infectious link. The second is non-inflammatory in nature.

[mscurefocus @mscure2020]

@Brandon_Beaber Swap out exercise for vitamin D and you’d be better. 😀

[mscurefocus @mscure2020]

2020/21 were bad years and progress toward a cure suffered both setbacks and advancement.

I am confident breakthrough therapy for MS will be available in 5-10 years which will safely put the brakes on this disease; but we are in a holding pattern for the next 3 years. 🤞🙏🏻

[mscurefocus @mscure2020]

@GavinGiovannoni The simple fact that we see progression of disease with AHSCT argues against it being a cure.

A highly effective treatment yes, but not a cure.

BUT, certainly using AHSCT first line should be studied given its effectiveness.

[mscurefocus @mscure2020]

Very interesting news. However it does point to the gut as a immunomodulator rather than primary driver in other disease (I.e #MultipleSclerosis).

[Vishal Gulati (I back scientists) @VishalGulati_]

This is crazy s**t!

Fecal transplant turns cancer immunotherapy non-responders into responders https://t.co/1uSXnB99bI

[mscurefocus @mscure2020]

Wow....what a 2020. Gonna start off 2021 with a poll. Pls retweet so it gets more exposure. 🙏🏻 #MultipleSclerosis

For #MSers who have gotten Ocrevus/Keysimpta/Rituxan, did your heat intolerance go away?

[mscurefocus @mscure2020]

@drbarrysinger @KlausSchmierer @BioNTech_Group @pfizer Kind of like using MRI activity as a surrogate for relapses IMHO, not scientifically proven but makes a whole lotta sense.

[mscurefocus @mscure2020]

@Chalenging_MS If you’ve never had this symptom before, consider seeing a medical professional ASAP.

[Brave Enough MD @RUBraveEnough]

Dear @wearfigs it’s me - a woman doctor

Holding Kaplan’s Cardiac Anesthesia RIGHT SIDE UP

The gold standard book for my subspecialty

Reading Chapter 15 Advanced Echocardiography Concepts (130 pages)

Of which I am the senior author.

Support women physicians. @AMWADoctors

[mscurefocus @mscure2020]

@GavinGiovannoni Reading through it now...but I have to say I love that you know that Poker is a game of skill.