Pleased to report randomized phase 2 of EP4 inhibitor ONO-4578 plus nivolumab and chemo for HER2-negative gastric/GEJ cancer in @JCO, concurrently at #ASCO2026@ASCO. ONO-4578 improved PFS (HR 0.67) and showed encouraging OS (HR 0.60), warranting phase 3.https://t.co/fLhukoRKu6
🌤️ The pancreatic cancer story is changing. RAS inhibitors are opening one front. Precision IO may be opening another. @ASCO 2026 we presented promising early 1L mPDAC data with CLDN18.2/CD47 bispecific spevatamig (PT886): ORR 52%, DCR 90.5%, mOS 14.7 months. ✨For the 1st time in decades, it feels like the code of this lethal disease is finally breaking✨.
@UPMCHillmanCC@OncoAlert@OncUpdates@OncBrothers
🆙 #ASCO26 Poster Session
🔥TRESBIEN/OGSG2101: BEACON Triplet for Early-Relapsed BRAFV600E-mutated CRC
✅ORR: 62.5% by BICR; DCR: 87.5%
✅Median PFS/OS: 7.4/33.9 m
✅Manageable safety: no Grade ≥3 AEs in ≥10% and no treatment-related deaths !!
@ASCO#ASCO26#CRC#BRAFV600E
@DrJNaidoo 20260518 In RNA-seq-based analyses (xCell), tumors lacking MTAP showed a significant reduction in the infiltration of CD4+ T cells, CD8+ T cells, and M2 macrophages, resulting in impaired immune checkpoint blockade (ICB) efficacy.
https://t.co/Cct9s8FHKF