Michael T Wolfinger

RNAForecast CEO | PI | RNA enthusiast with a passion for structure, dynamics, viruses, and evolution 🧬🦠

[Michael T Wolfinger @mtwolfinger]

Next week in Vienna, I'll be speaking at #RNALeaders Europe about RNA structure prediction with modified nucleotides and the role of the ViennaRNA Package in advancing computational RNA analysis. https://t.co/EBiBL1ubSY #RNA #ViennaRNA #Vienna #RNAtherapeutics #RNAvaccines

[Michael T Wolfinger @mtwolfinger]

Beyond #syntheticBiology this opens new avenues for RNA therapeutics: mechanically defined RNA elements that enhance transcript stability and protect RNAs from exonucleolytic decay without relying on native viral sequences
#RNAbiology #RNAstructure #RNATherapeutics #ViennaRNA

[Michael T Wolfinger @mtwolfinger]

🧬 New preprint out!
Rational design of mechanically active RNAs: de novo engineering of functional exoribonuclease-resistant RNAs (xrRNAs).
We demonstrate that RNA mechanical function can be designed from first principles without relying on evolutionary sequence ancestry.

[biorxiv_biochem @biorxiv_biochem]

Rational design of mechanically active RNAs: de novo engineering of functional exoribonuclease-resistant RNAs https://t.co/SB6d2xmE2F #biorxiv_biochem

[Michael T Wolfinger @mtwolfinger]

To our knowledge, this is the first example of a fully de novo engineered non-coding RNA with experimentally validated mechanical function.

Using topology- and mechanics-aware design, synthetic xrRNAs reproduce wild-type-like resistance to 5′→3′ exonucleases.

[Michael T Wolfinger @mtwolfinger]

ViennaRNA Package v2.7.1 is out! 🧬🎉 Solid update: smoother probing-informed folding (SHAPE/DMS), improved constraints handling, and nicer Python multistrand base-pair probs.
Get: https://t.co/vWUNvvE7w4
Source: https://t.co/Qq2WN8FHEc
#ViennaRNA #RNA #ComputationalBiology

[Michael T Wolfinger @mtwolfinger]

Calling #RNA & #Virology researchers! 🧬🦠
Submissions are open for the open-access Special Issue '𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝗮𝗹 𝗥𝗡𝗔𝘀 𝗶𝗻 𝗩𝗶𝗿𝗼𝗹𝗼𝗴𝘆' in MDPI Viruses, which I'm guest editing.
📝 Original research & reviews!
🗓️ Deadline: Feb 28, 2026
https://t.co/sL1uOd1dBK

[Michael T Wolfinger @mtwolfinger]

Calling all #RNA & #AI researchers! 🧬🤖 Submissions are open for the new open‑access collection “Exploring RNA Biology with Deep Learning Algorithms” in RNA Biology that I am guest editing with @YiliangDing 📄⬇️ https://t.co/gQzF5ckD5S #DeepLearning #bioinformatics #CompBio

[Michael T Wolfinger @mtwolfinger]

🚀 Our new review unveils how Musashi proteins engage UAG & AGAA motifs in viral RNAs, revealing hijack tactics & guiding next-gen antivirals! 🦠💊 Dive in 👉 https://t.co/2flxoqMdQe #RNAProtein #AntiviralTherapy #ComputationalBiology #RNA #virus #Zika

[Ramya Rangan @ramyarangan]

Do you love RNA biology and RNA structure? Join us at Atomic AI to shape the future of AI-driven drug discovery targeting RNA! We’re hiring for a computational RNA expert - check out this job posting here: https://t.co/l85R3qSKCF

[Danny IncaRNAto @incaRNAtolab]

Happy to be featured in this Technology Feature by Michael Eisenstein in Nature Methods about the present and future of #RNA structure analysis, along with @ywan_wan, @RouskinLab, @JosephYesselman and many other colleagues working in this amazing field!

https://t.co/Sv4SVawBnX

[Jonas Schmidt-Chanasit @ChanasitJonas]

Zwei schwere #Borna #Virus 🦠-Fälle in #Bayern Der @donaukurier berichtet sehr sachlich & ohne Panikmache!
Das Bernhard-Nocht-Institut ist das Konsiliarlabor für Bornaviren und steht für alle Fragen zur Verfügung. ⁦@hh_bwfgb⁩ ⁦@unihh⁩ https://t.co/HfqQR8vu27

[Marion Koopmans, publications: https://pure.eur.nl @MarionKoopmans]

Insect flaviviruses (replication deficient in human cells) as vector for arbovirus vaccines: example of recombinant virus developing protective immunity in macaques https://t.co/WkDaVHdQVY

[Danny IncaRNAto @incaRNAtolab]

Please retweet 🙏: 2 @ERC_Research-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: https://t.co/pYJ3H3j705

[Michael T Wolfinger @mtwolfinger]

#ViennaRNA v2.7.0 is out 🎉 with G-quadruplex support for circular RNAs, new methods for integrating #RNA structure probing data & energy parameters for modified bases like m5C and N1-methyl-pseudouridine. Plus many API improvements and bug fixes https://t.co/5ZzHbyt575 #Vienna

[Michael T Wolfinger @mtwolfinger]

Thrilled to have our outstanding PhD students, Leonhard Sidl and Jule Walter present our latest findings on artificial xrRNAs and synthetic xrRNA riboswitches at the German Conference on Synthetic Biology. #GCSB #computationalbiology #biochemistry #RNA #ViennaRNA

[Danny IncaRNAto @incaRNAtolab]

Very excited to share our latest preprint, led by rockstar post-doc @i_borovska. Our humble attempt to begin exploring #RNA secondary structure ensembles in a living cell (https://t.co/XMHdvLLUq6) (1/n)

[Judith Aberle @AberleJudith]

West Nil Virus in Österreich
- 21 Fälle bestätigt (Stand 3.9.2024)
- davon 10 neurologische Erkrankungen
- NÖ, Bgld, Wien, sowie importierte Fälle aus Kroatien und Ungarn
#NationalesReferenzzentrum für humane #Arbovirusinfektionen #MedUniWien

KARTE https://t.co/ndJ6SUCOkS

[Michael T Wolfinger @mtwolfinger]

@YannPonty @ppgardne Both of you will be missed!!!

[Michael T Wolfinger @mtwolfinger]

On the way to #Barcelona to attend the 2024 #Benasque #RNA meeting for the next two weeks 🧬🌐

[Michael T Wolfinger @mtwolfinger]

Excited to share our latest paper /w @RhysHParry on Xinyang flavivirus (XiFV) discovery in ticks from #China! Our research unveils unique structural #RNAs in the 3' UTR, shedding light on viral replication and translation mechanisms. https://t.co/Numqco7alN #Virology 🦟🔬