Excited to share that our work on the molecular evolution of CRISPR-Cas9 is out in @NatureSMB! By determining four IscB/Cas9 structures, we traced sequence of events from IscB to Cas9 and revealed how these nucleases enhanced DNA-targeting specificity.
https://t.co/K9Hn7n4pca
Our preprint is now online!
Sena1, a "super-disordered" protein, acts as a molecular lubricant that keeps aggregation-prone proteins with extended IDRs moving smoothly in the nucleus.
A wonderful collaboration with Dr. Yuki Tomari at the Univ of Tokyo.
https://t.co/RRrLiT1PZW
1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio@ColumbiaBME@Columbia
https://t.co/ZT3Ygw9tiG 🦠🧬🛠️🖥️💥
Early registration for the CRISPR 2026 meeting is extended until March 15, 2026. The Abstract deadline is March 31, 2026. Registration is required before submitting an abstract.
https://t.co/Df7HPUOHiU