Niccolò Arecco

Twitter is dead, find me at Postdoc @CRGenomica.
Previously: @EMBO Postdoc Fellow, PhD @EMBL.
Semi-Professional Pizza Enthusiast.

[Niccolò Arecco @NccAcc]

.@GoogleDeepMind are you planning to release #AlphaGenome predictions for each 1Mb bin of the human genome at some point?

It would be great to have them in @ensembl or @ucsc genome brower.

(Similarly to AlphaFold predictions for all proteins on UniProt)

Thanks!

[Dr. Kaia Mattioli @kaia_mattioli]

Earlier this year, I learned I have a pathogenic variant in BRCA2, which gives me a very high lifetime risk of breast cancer (55-69%), as well as an increased risk of ovarian cancer (12-29%) and pancreatic cancer (5-10%).

🧵1/ …

[Max Jaderberg @maxjaderberg]

Excited to share that the AlphaFold 3 model code and weights are now available for academic use.
Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries https://t.co/GKIOGHm317 1/2

[PayerLab @PayerLab]

Xciting news + Jobs alert! 🚨 After wonderful years at @CRGenomica, we are relocating beginning 2025 to @ChuSteJustine at @UMontreal. If you want to be part of @payerlab 2.0, come and join us! We are hiring at all levels – see job ads in the thread 🧵below. 👇 1/5

[Niccolò Arecco @NccAcc]

@TriggerLoop and only ~4000 words to make sense of it

[Niccolò Arecco @NccAcc]

@jordixiol I'm not an expert here, can you clarify how come a drug that failed phase 3 can still get FDA approval?

[Niccolò Arecco @NccAcc]

@MED_COMPLEX is this AF3?

[Niccolò Arecco @NccAcc]

@marcotrizzino You can get them from an ENSEMBL GTF file:

wget https://t.co/ejVapng2xI

zcat Homo_sapiens.GRCh38.112.gtf.gz | head -n 150 | grep -v "^#" | grep "exon" | cut -f 1,4-7 | uniq

Of course there'll a lot of crap in it

[Niccolò Arecco @NccAcc]

This is exciting!

[Pushmeet Kohli @pushmeet]

We love the excitement & results from the community on AlphaFold 3 and are doubling the AF Server daily job limit to 20. Happy to also share that we're working on releasing the AF3 model (incl weights) for academic use, which doesn’t depend on our research infra, within 6 months.

[Niccolò Arecco @NccAcc]

THIS! 👇

[Niccolò Arecco @NccAcc]

Where's the code+params?
Please!

[Google DeepMind @GoogleDeepMind]

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬

Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 https://t.co/gjw6Ip4F2M

[Niccolò Arecco @NccAcc]

@R_Mallarino @JorgeMorenoPhD @Nature Super cool story and thanks for all those marsupial genomes! 🙏

[Niccolò Arecco @NccAcc]

@cemkansu Is there a way to de-activate animations?

[Niccolò Arecco @NccAcc]

"2/3 of of alternative TF isoforms exhibit differences in one or more molecular activities"

https://t.co/eytJX1han9

[Luciano Di Croce @ludicroce]

Very happy to see our work on the unexpected role of splicing in regulating Polycomb assembly, occupancy, dimerization and histone mark deposition.
Great team work with @mirimiam, @NccAcc, @Ivuaenneo, among others! https://t.co/TroEDeR1w2

[Niccolò Arecco @NccAcc]

@jakob_tr @MolecularCell I know right?!

[Niccolò Arecco @NccAcc]

For the busy people with no time, Ivano made this great meme to capture the essence of our findings 😎

[Ivano Mocavini @Ivuaenneo]

PRC2 with splicing characteristics
Our story is finally out on @MolecularCell
TL;DR:

[Niccolò Arecco @NccAcc]

@PayerLab @mirimiam @Gabrijela_D @MolecularCell @Ivuaenneo @DiCroceLab Maybe the X chromosome next? 😍

[Molecular Cell @MolecularCell]

Online Now: Alternative splicing decouples local from global PRC2 activity https://t.co/l5dU8NL1MX