Needful

21
Huge Nerd (Anime, Marvel, DC, Star Wars)

[Needful @Needful_HP]

@hiddenhush This shit is literally such a good show man. The writing, cinematography and CGI is absolutely dope. Just LOOK at these visuals

[DRUSKI @druski]

How Conservative Women in America act 😂🇺🇸

[DiscussingFilm @DiscussingFilm]

OpenAI is shutting down its AI video slop-making platform Sora.

[The Cinéprism @TheCineprism]

Hans Zimmer cooked 🔥

[kiara : KAYDA TO THE FINALS @jetweste]

how it feels to know i never switched up on timothée

[DiscussingFilm @DiscussingFilm]

The first trailer for ‘DUNE: PART 3’ has been released.

In theaters on December 18.

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[COLE @colehairlesscat]

Thank you, Dr. Mariano Barbacid!

[All day Astronomy @forallcurious]

BREAKING🚨: This is Mariano Barbacid, the scientist who may have discovered the cure for pancreatic cancer.

[Spencer Hakimian @SpencerHakimian]

🚨BREAKING: Alex Pretti’s Colleagues Hold a Moment of Silence.

[DiscussingFilm @DiscussingFilm]

“I Lied To You” from ‘SINNERS’ is now an Oscar-nominated song.

Miles Caton is one of the youngest Oscar nominees ever in his category.

[DiscussingFilm @DiscussingFilm]

‘SINNERS’ has broken history as the MOST-NOMINATED FILM OF ALL TIME at the Oscars with 16 nominations

See the full nominees list: https://t.co/IuSVQZPi7d

[ToonHive @ToonHive]

The Season 2 ending of ‘Frieren: Beyond Journey’s End’ was fully hand-drawn using only colored pencils, created by artist Mimei Aoume (@aoumemimei).

[Abhishek @abhishekcode42]

You watch first 4 seasons of this series, thinking it's so good, so good.
Then season 5 and season 6 take the peak to the newer peaks.
One of all time great shows.

[DiscussingFilm @DiscussingFilm]

Sebastian Stan is playing Harvey Dent in ‘THE BATMAN: PART 2’

(Source: https://t.co/FsjC1dk7CW)

[Needful @Needful_HP]

@DM_Arts_ Can you make these as wallpaper engine backgrounds?

[AnimeTV チェーン @animetv_jp]

【Official Teaser】
Black Clover New Season
Scheduled for 2026 on Crunchyroll!
#ジャンプフェスタ #JumpFesta2026

✨More: https://t.co/QoE2PGo7Nl

[DiscussingFilm @DiscussingFilm]

‘DAREDEVIL: BORN AGAIN’ Season 2, ‘INVINCIBLE’ Season 4 and ‘THE BOYS’ Season 5 will all release new episodes during the same time.

[thenerdking @thenerdking215]

The US is literally trying to force the strawhat flag into alt right protest groups to try to change how the public views it as a symbol.

Don’t let the literal world government try to twist the meaning of One Piece.

One Piece = liberation, not far right oppression.