CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!
With the growing availability of spatial omics data from different techniques, CAST offers a computational tool for reconstructing single-cell multi-omic profiles and downstream analysis in a spatially resolved manner. @WangXiaoLab
https://t.co/iIdviIu4Wi
Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues @LDangliang and @AbhiAditham . Huge thanks to my supervisor @WangXiaoLab for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.
Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: https://t.co/iGynbJb8b8
Happy to share CAST as the "BLAST" tool for spatial omics, searching and aligning similar patterns across datasets while revealing their differences with prototype demo of querying new data against reference spatial atlas and comparative spatial studies👇https://t.co/lNaPq9FwiQ
Excited to share Deep-STARmap and Deep-RIBOmap! We enabled spatial transcriptomic and translatomic mapping of >1K genes in 200 µm thick tissue and neuron morphology co-profiling.
Thanks @WangXiaoLab for unwavering support; Jennifer for human skin study! https://t.co/2m099QLrCX
The field of #ComputationalBiology has changed dramatically in the last few years with #GenerativeAI.
I'm excited to be recording my lectures again this year, and to be teaching with the awesome @EjAlm.
You can find the first lecture here: https://t.co/dBuv9M2aOX
and more will be coming in the playlist below.
Fall 2024: https://t.co/o5RBYluZXI
Spring 2021: https://t.co/1rHgfil6W2
Fall 2020: https://t.co/ekCtSr6qMn
#CompBio #DeepLearning #MachineLearning #Genomics #Therapeutics #RepresenationLearning #Chemistry #ProteinFolding #ClinicalRecords #SingleCell
CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!
With the growing availability of spatial omics data from different techniques, CAST offers a computational tool for reconstructing single-cell multi-omic profiles and downstream analysis in a spatially resolved manner. @WangXiaoLab
https://t.co/iIdviIu4Wi
With the growing availability of spatial omics data from different techniques, CAST offers a computational tool for reconstructing single-cell multi-omic profiles and downstream analysis in a spatially resolved manner. @WangXiaoLab
https://t.co/iIdviIu4Wi
Spatial omics technology is transforming our understanding of in situ RNA biology. We are grateful for the opportunity to publish this review in @MolecularCell. We hope this will be a useful resource for the community. @HailingShi@nemo08061@WangXiaoLab
NOW AVAILABLE - The #BICAN webinar highlighting new information about the whole mouse brain atlas is now available for replay.
Watch: https://t.co/WFvACCqOSV
#studyBRAIN@USBrainAlliance@Nature
It has been a great pleasure working on this project in which the the initial idea came from creative insights on a protein structure. Huge thanks to @HaotianDu4, Possu and everyone❤️❤️❤️
How do we uncover cell-cell interactions from #SpatialTranscriptomics data? Excited to share Niche-DE (https://t.co/0LSSqYgodz). Niche-DE asks how does a cell’s transcriptome depend on its spatial neighbors, by identifying Niche-Differentially Expressed genes. 1/9
Thrilled to see our work finally online! We utilized in situ spatial transcriptomic method STARmap PLUS to map 1.09 million cells in the adult mouse central nervous system at molecular resolution and identified previously unknown tissue architectures.
https://t.co/9tsNO6lvRj
Love napari but missing some ImageJ functions? Look no further than napari-imagej, which provides an accessible and comprehensive solution to ImageJ ecosystem access from napari. https://t.co/9kz9i3LNbL