Paul Garrity

Prof. Biology, Brandeis. We study how flies/mosquitoes sense. Grateful to be part of @BrandeisMCB and @BrandeisNeuro. (R. Busby (logo) & C. Zhu).

[Paul Garrity @Nemvec]

Congrats Julianne!

[Paul Garrity @Nemvec]

@FedExHelp Fedex driver pulled up outside our house, then drove off without exiting vehicle. We were there/opened door. 30 min later app says we were "unavailable". Called CS, they claimed we had called to call off delivery at our house (which we had not). We are concerned.

[Josefina del Mármol @MarmolJosefina]

Attending ASCB|EMBO? Join us for a Special Interest Subgroup on Sensory Receptors, featuring @EGouaux15625 @RachelleGaudet Maude Baldwin @MPIforBI Juan Du @DuLuLabs @CoreyAHAllard and Eric Mulhall, co-organized with Paul Garrity @Nemvec @ASCBiology @EMBO #cellbio2024

[Paul Garrity @Nemvec]

@Goodflies thanks Bing!

[Paul Garrity @Nemvec]

How do mosquitoes find people to bite & places to lay eggs? Turns out, sensing water vapor is key. In new work we (Tang et al.) ID mosquito receptors for dry/moist air. KO'ing them drops blood feeding and renders females unable to find water to lay eggs. https://t.co/KPqYRS0wGE

[Brandeis University @BrandeisU]

Ava Towle '26 studies how fruit flies sense temperature through G-Protein Coupled Receptors in the Shapiro Science Center lab, highlighting some of the exciting research on campus this summer. #Research #Brandeis

📸 Gaelen Morse/Staff photographer

[Ardem Patapoutian @ardemp]

My autobiography is now published on the @NobelPrize website. It covers both my personal and professional life, highlighting the decisions and events that have had the biggest impact. I appreciate the opportunity to tell my story. Hope you enjoy reading it
https://t.co/G0BRNCzNkH

[Paul Garrity @Nemvec]

@CellReports Preview from Talross and Carlson (thanks!)

[Cell Reports @CellReports]

Sugar detection in 3D: Structure of an insect gustatory receptor https://t.co/j5c4uucc20

[Paul Garrity @Nemvec]

Now out in final form: Structural basis of ligand specificity and channel activation in an insect gustatory receptor (w/ our collaborators in the Gaudet lab)
https://t.co/IIAlTO9ZZU

[Huck Institutes @huckinstitutes]

Friday's retreat of the Center for Molecular Investigation of Neurological Disorders brought together neuroscientists and related researchers from UP and @PennStHershey with guests like keynote speaker @Nemvec.

See all the pics on our Flickr album: https://t.co/lsgn3D6ru0

[Paul Garrity @Nemvec]

Sad news: John DeModena, long-time tech w/@wormraiserand friend to so many of us, has passed. Demo’s generosity of spirit and enthusiasm for life were inspiring. There will be a celebration of Demo’s life 1/27 in the Morgan library

[Paul Garrity @Nemvec]

@Olfactozone Thanks Anand!

[Paul Garrity @Nemvec]

Preprint: Structure of an insect gustatory receptor. Heather Frank, Sanket Walujkar, Richard Walsh, Willem Laursen, Doug Theobald, me and Rachelle Gaudet. Collaborative effort 5 years in the making! https://t.co/bgvxw49ACT 1/4

[Paul Garrity @Nemvec]

@Goodflies Thanks Bing. Grateful to get to participate alongside people like Rachelle, Heather, Sanket, Richard, Doug and Willem. Have been wanting to know better what these things meant since the days of Gr28b!

[Paul Garrity @Nemvec]

@RachelleGaudet @HC2EM

[Paul Garrity @Nemvec]

For GR fans: Signature motif residues (TYhhhhhQF) make specific contributions to pore helix: T helps form hydrophilic path; Y binds lipid head group; QF gates pore entrance. Also new: intersubunit fenestrations of both GRs and ORs are inhabited by pore-penetrating lipids. 4/4

[Paul Garrity @Nemvec]

Take homes: Unlike known ORs, Gr9’s ligand-binding pocket is larger, solvent accessible and heavy on polar/aromatics. Using structure-based alignments and alphaFold, we leverage this to examine structural and chemical properties of GRs more broadly. 3/4

[Cheng Huang @ChengHuangThu]

We are back to business! The very first in vivo voltage imaging in Huang lab. Look at how this neuron changes firing mode. This simplistic voltage scope only costs ~$50k, mostly @Thorlabs parts. Let me know if you want a full part-list to build your own one.