Nested Therapeutics

Nested aims to advance precision oncology medicine by finding new driver mutations hiding in plain sight to reach a broader group of patients.

[Nested Therapeutics @nestedtx]

That’s a wrap on #AACR2026! Thank you to the researchers, clinicians, and patients who made this a milestone week for NST-628 and the Nested team. More to come!

#Oncology #Biotech

[Nested Therapeutics @nestedtx]

Today at #AACR2026: Dr. Tarhini is presenting initial Phase 1 NST-628 dataset
https://t.co/fDecCkK55X

[Nested Therapeutics @nestedtx]

Two years after unveiling NST-628 at AACR’s New Drugs on the Horizon and in Cancer Discovery, we're excited to share preliminary Phase 1 data for our novel, fully brain-penetrant, pan-RAF/MEK molecular glue at #AACR26 in San Diego. https://t.co/6cza6gZzEz

[Cancer Discovery @CD_AACR]

Watch first author Meagan B. Ryan discuss her research article, NST-628 is a novel and potent pan-RAF-MEK inhibitor, published simultaneously at #AACR24:
https://t.co/s4TJxWjQQi
@nestedtx

[BiotechTV @BiotechTV]

AACR24: Having entered the clinic last night, @nestedtx's CEO discusses the preclinical profile of a brain-penetrant, pan-RAF/MEK molecular glue. #AACR24

Full video: https://t.co/LqaCvOyOBw

[Nested Therapeutics @nestedtx]

Our CSO, @ Klaus Hoeflich, recently sat down with @ Sally Church on Nested’s progress. Check out the interview on Biotech Strategy Blog and discover our impressive journey from concept to clinic in just three years. #NST628 #NestedTherapeutics #biotech
https://t.co/CAgtk57c87

[OncWeekly @OncWeekly]

FDA clears @nestedtx Nested Therapeutics' IND application for NST-628, a promising treatment for solid tumors. #oncology #cancerresearch #FDA #FDANews #OncWeekly https://t.co/ut2zbXX07l

[Cancer Discovery @CD_AACR]

Just published with the #AACR24 New Drugs on the Horizon presentation—
The pan-RAF-MEK Non-degrading #MolecularGlue NST-628 Is a Potent and Brain-penetrant Inhibitor of the RAS-MAPK Pathway with Activity Across Diverse RAS- and RAF-driven Cancers
https://t.co/FC2VNFPcvM
@nestedtx

[Elizabeth McKenna @ElizSMcKenna]

Congratulations to Klaus Hoeflich and co-authors at @nestedtx on this simultaneous #AACR24 publication in @CD_AACR!

[Nested Therapeutics @nestedtx]

Yesterday at AACR, we unveiled the preclinical data on our lead program, NST-628, during an oral presentation as part of the “New Drugs on the Horizon” series. For more insights, visit our website and stay tuned for more updates!

https://t.co/2zCdwVmZHK

[Nested Therapeutics @nestedtx]

We're proud to announce the FDA clearance of our IND Application for NST-628. Additionally, our CSO, will present pre-clinical data on NST-628 at the “New Drugs on the Horizon” Series at the 2024 AACR Annual Meeting. Stay tuned for more updates! https://t.co/xIZ146WLJO

[Nested Therapeutics @nestedtx]

Today, we announce the appointment of three members to our board of directors. “We look forward to partnering with them as we continue to build our pipeline and advance our first program into the clinic this year.” - Darrin Miles, CEO

https://t.co/sJeSe5Fg43

[Nested Therapeutics @nestedtx]

We are thrilled to share we’ve been recognized in BioSpace's prestigious NextGen Bio Class of 2024 of the hottest new life sciences companies. Cheers to an extraordinary journey ahead! #NextGen2024 #Innovation

Learn more here: https://t.co/gnq7sfCzlU

[Nature Biotechnology @NatureBiotech]

Our list of the best R&D-intensive startups spun out of universities in 2022 includes companies correcting misfolded proteins, creating second-generation GPCR agonists and mining cancer genomes for novel targets #NBTAcademicStartups https://t.co/e4srawnuGW
https://t.co/6FMj2CNZZL

[Nested Therapeutics @nestedtx]

We're excited to be featured in “Precision Oncology News” highlighting our co-founders, innovative platform and growing pipeline. Our lead compound NST-628, is anticipated to enter clinical trials in early 2024. Read more about us & the compelling science here!

[Nested Therapeutics @nestedtx]

Happy #Thanksgiving from all of us at Nested Tx!

As we head into the holiday season, let's take a moment to unwind and reflect on the impactful contributions we make every day. May this time be filled with relaxation, joy, and moments of #gratitude with loved ones!

[Nested Therapeutics @nestedtx]

Exciting news! @NewEnglandVC is set to host its 11th Annual NEVYs, and we've just received a nomination for the Emerging Life Science Company of the Year award!

Curious to find out the results? Join us on December 7th at https://t.co/irtRU99cZm! 🏆 #NEVYs23 #LifeScienceAward

[Nested Therapeutics @nestedtx]

We are #hiring! This position will be responsible for developing and preparing global regulatory strategies for multiple programs.

Reach out to learn more about us and our unique platform at [email protected]!

#precisiononcology #clinicaldevelopment #biotech

[Nested Therapeutics @nestedtx]

A huge round of applause to our presenters for an exceptional job representing Nested Therapeutics at the AACR-NCI-EORTC Conference in Boston! The team’s passion, expertise and dedication shined through as they showcased our strides made with NST-628.

#PrecisionMedicine

[Nested Therapeutics @nestedtx]

You can learn more about it here: https://t.co/sistZNYEoS

[Nested Therapeutics @nestedtx]

Today, at the 2023 AACR-NCI-EORTC Conference, we unveiled the first preclinical data on the mechanism of action, efficacy and brain penetrance of our lead candidate, NST-628, a mechanistically novel non-degrading molecular glue targeting multiple nodes in the RAS/MAPK pathway.