Ying Cao

My rubbish research: the core property of cancer cell is neural stemness, which determines pluripotency&tumorigenicity.
EMT/MET/EndMT are groundless 'concepts'

[Ying Cao @NeuralGrndState]

@CellCellPress Understanding
cancer cell/metastasis/complexity/therapy
&even the inverse correlation between cancer and Alzheimer's
&...
as a whole
by understanding neural stemness as the core property of cancer cell
&the rules dictated by neural stemness.

https://t.co/I3VYJr5P24

[Ying Cao @NeuralGrndState]

Understanding metastasis by devising poorly defined concepts?
Nobody knows what is EMT, incl. specific markers, reg. nets, cellular properties, etc.
How about MTM? specific markers, reg.nets, cellular properties, etc.
If unknown, what it can help, like EMT? @CellCellPress

[Cell @CellCellPress]

In the latest issue! A 3D morphogenetic blueprint for metastatic outgrowth in breast cancer https://t.co/5wI3qNBjZR

[Ying Cao @NeuralGrndState]

@CellCellPress The core EMT factors&the master MTM regulators are represented by different mol. symbols.

But they are all embryonic neural (crest) factors, belonging to the reg. net. of neural stemness.

Guess what?
A key feature of neural stem/crest/progenitor cells is
SINGLE CELL MIGRATION.

[Ying Cao @NeuralGrndState]

Cancer is a systemic disease.
Understanding a systemic disease needs the understanding of systemic rules.
Or cancer is the manifestation of the power of the general rules dictating the animal kingdom, which are predetermined by evolution. @NutrioSci

[Nutrition Science @NutrioSci]

Tumor metabolism at the center of the cancer hallmarks

Examining tumor metabolism within the multidimensional hallmark framework provides a theoretical basis for developing more effective combinational therapies.

Open Access
https://t.co/2a6ug3Djz2

[Ying Cao @NeuralGrndState]

Understanding
cancer cell
&cancer complexity/metabolism
&even the inverse correlation between cancer and Alzheimer's
...
as a whole
by understanding neural stemness as the core property of cancer cell
&the rules dictated by neural stemness.
https://t.co/I3VYJr5P24
@NutrioSci

[Nutrition Science @NutrioSci]

Tumor metabolism at the center of the cancer hallmarks

Examining tumor metabolism within the multidimensional hallmark framework provides a theoretical basis for developing more effective combinational therapies.

Open Access
https://t.co/2a6ug3Djz2

[Ying Cao @NeuralGrndState]

Basic logic:
Metabolism is not an independent feature.
Metabolic modes are cell type dependent.
If you wish to emphasize the central importance of metabolism in cancer cell, you should make a clear definition and clarification.
Otherwise, what does it help? @NutrioSci

[Nutrition Science @NutrioSci]

Tumor metabolism at the center of the cancer hallmarks

Examining tumor metabolism within the multidimensional hallmark framework provides a theoretical basis for developing more effective combinational therapies.

Open Access
https://t.co/2a6ug3Djz2

[Ying Cao @NeuralGrndState]

@michaelzlin @StephenAtHome But how much have cancer cell&CANCER been understood?

[Ying Cao @NeuralGrndState]

@michaelzlin @StephenAtHome But how much have cancer cell&can been understood?

[Ying Cao @NeuralGrndState]

@michaelzlin @StephenAtHome understanding
cancer cell
&cancer complexity
&cancer therapy
&even the inverse correlation between cancer and Alzheimer's disease
&...
as a whole
by understanding neural stemness as the core property of cancer cell
&the rules dictated by neural stemness.
https://t.co/HJsjJin9C4

[Ying Cao @NeuralGrndState]

@michaelzlin @StephenAtHome But how much have cancer cell&can been understood?

[Ying Cao @NeuralGrndState]

@michaelzlin @StephenAtHome But how much have cancer cell&can been understood?

[Ying Cao @NeuralGrndState]

The 'synthetic lethal' approach:
blocking the cancer-promoting reg. net., i.e., reg. net of neural stemness, by non-neural differentiation factors

[Samuel Hume @DrSamuelBHume]

This week in medicine

1. A synthetic lethal approach adds to RAS inhibition in pancreatic cancer
2. A potentially best-in-class ulcerative colitis drug
3. Discovery of a defined autoimmune subtype of inflammatory bowel disease
4. Genetic therapies for sickle cell keep working
5. More data on muscle-sparing weight loss

[Ying Cao @NeuralGrndState]

@AnthropicAI Biology is not just coding.

[Ying Cao @NeuralGrndState]

All roads lead to Rome.
Different starting points, different paths

[Ying Cao @NeuralGrndState]

Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent, &not just HLA problem

[Ying Cao @NeuralGrndState]

Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent, &not just HLA problem

[Cancer Cell @Cancer_Cell]

Cancer type-specific variation in patterns of driver alterations across 50,000 tumors https://t.co/PfCqPwXSNu

[Ying Cao @NeuralGrndState]

@Cancer_Cell All roads lead to Rome.
Different starting points, different paths

[Ying Cao @NeuralGrndState]

Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent, &not just HLA problem
@Cancer_Cell

[Ming "Tommy" Tang @tangming2005]

Cancer type-specific variation in patterns of driver alterations across 50,000 tumors https://t.co/iX4GCUF6oM

[Ying Cao @NeuralGrndState]

All roads lead to Rome.
Different starting points, different roads.
@Cancer_Cell

[Ying Cao @NeuralGrndState]

Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent
@Cancer_Cell
https://t.co/qyEelXxoMS

[Ying Cao @NeuralGrndState]

Basic logic:
Tumorigenesis means progressive loss of original cell identity&gain of neural stemness
Whether a mutation drives cancer depends on whether it can confer cells with neural stemness
This is highly cell context dependent
@Cancer_Cell
https://t.co/qyEelXxoMS

[Ying Cao @NeuralGrndState]

ddx6 and adar1 are mainly embryonic neural

[Science Immunology @SciImmunology]

The RNA helicase DDX6 promotes immunosuppression in #cancer by repressing ADAR1-mediated #dsRNA stabilization, preventing interferon activation. Learn more in Science #Immunology: https://t.co/bopxCSqQYp