Nigel DRUMMOND

Exploring the neurochemical nexus | Cannabinoid receptors, opioid crisis, and science-driven solutions | MA Natural Sciences, Cambridge | MBA Wharton.

[Nigel DRUMMOND @nigeldrummond]

@farzyness @grok How to get into Sussex house

[Nigel DRUMMOND @nigeldrummond]

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[Nigel DRUMMOND @nigeldrummond]

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[Nigel DRUMMOND @nigeldrummond]

@ProjectConstitu Lllllllllllllolllllllllllllllllll’o

[Nigel DRUMMOND @nigeldrummond]

@JudiciaryGOP X

[Nigel DRUMMOND @nigeldrummond]

6/ As someone fascinated by neurochemistry and societal impact, I believe cannabinoid science could be part of the solution. What’s your take? Let’s discuss.

[Nigel DRUMMOND @nigeldrummond]

The Opioid Crisis and Cannabinoid Research

Let’s explore the intersection of cannabinoid science and the opioid crisis. A thread 🧵:

[Nigel DRUMMOND @nigeldrummond]

5/ Research is still in its early stages, but the implications are vast:
•Fewer overdoses
•Safer treatments for chronic pain
•Improved quality of life for millions

[Nigel DRUMMOND @nigeldrummond]

CANNABINOID RECEPTORS IN HUMANS

The cannabinoid system is a fundamental building block of human health with receptors in major organs, joints, the brain, and most parts of the human body. Many base Cannabinoids bind to CB1 or CB2 receptors which belong to the G-protein-coupled receptor (GPCR) family and are important mediators of the action of those cannabinoids. Pure CBG, CBDA, CBGA, CBDV and CBGV are differentially acting on CB1 or CB2 cannabinoid receptors.

CBG and CBGA bind to a larger range of additional receptors and are considered partial agonists at the CB1 receptor (R) and CB2R, as well as a regulator of endocannabinoid signalling. Potential pharmacological targets for CBG include transient receptor potential (TRP) channels, cyclooxygenase (COX-1 and COX-2) enzymes, cannabinoid, 5-HT1A, and alpha-2 receptors.

CBDA has also been shown to bind with different receptors from those for CBD (which only binds to CB1 and CB2) including 5-HT. This has led to successful research for CBDA and CBGA in a wider range of conditions.

[Nigel DRUMMOND @nigeldrummond]

@shivon Very cool.

[Nigel DRUMMOND @nigeldrummond]

Prescription Painkiller Crisis: The opioid epidemic originated from the overprescribing of prescription painkillers. In 2012, healthcare providers wrote 259 million opioid prescriptions, enough for every adult in the U.S. to have a bottle of pills.

[Nigel DRUMMOND @nigeldrummond]

Overdose Deaths: In 2020, more than 93,000 drug overdose deaths were reported in the United States, and opioids were involved in approximately 70% of those cases, according to provisional data from the Centers for Disease Control and Prevention (CDC).

#opiods #thc #thca

[Nigel DRUMMOND @nigeldrummond]

10 mind-blowing facts/statistics about the opioid epidemic in America: