Nick Myles

MD, Pathologist, Clinical professor, UBC

[Nick Myles @nmakrets]

@dnunan79 @Catalogofbias I'd say spectrum bias in diagnostic testing AI

[Nick Myles @nmakrets]

@BMJ_EBM @AdeAdamson @KatyJLBell @DellMedSchool @SydneySPH @DellMedCPC So, what could be done differently? Not to diagnose melanoma in situ and not to exise it and play gamble? We admit MIS diagnosis is not life threatening, everyone knows.

[Nick Myles @nmakrets]

@BMJ_EBM @EmmaGrundtvig I wonder if data presented reflect a. invasive vs non-invasive melanoma b. thickness of invasive melanoma as the strongest predictors of outcome. If patient presents with the pigmented lesion we have to diagnose it by applying current criteria.

[Nick Myles @nmakrets]

@karamchandanij @CAPACP Hi Jason, let me know if I could be of any help. I am now at IARC /WHO in Lyon. Perhaps we can design a course or sumposium for the next CAPACP convention. Best wishes

[Nick Myles @nmakrets]

@oke_jason WOW! Goal is set to increase cancer incidence at low stage ... We know it will work, thank you, lead time bias!

[Nick Myles @nmakrets]

@dnunan79 minimum ?.a choice of: contribution to design, data collection and study execution, analysis, drafting and /or substantial scientific editing..no different to the formal authroship rules. Pure technical/spell check would be insufficient, but good for kind acknowledgement !

[Nick Myles @nmakrets]

@MUNMed I am curious did you adjust to stage?

[Nick Myles @nmakrets]

@LeQuesneLab @NHSGGC Sweet and beautiful !

[Nick Myles @nmakrets]

@LeQuesneLab @xolisajane Hi John how;s life?

[Nick Myles @nmakrets]

@carlheneghan ..No, we are obliged to condemn any calls to lift it.

[Nick Myles @nmakrets]

@LeQuesneLab @xolisajane Agree. I saw myself in emerge, OR, or ..in the autopsy suite. I still loved to talk to live patients thought, despite all these years in path, but not in the wards...

[Nick Myles @nmakrets]

@oke_jason Jason, one inevitably hit death classification bias issue/ competing mortality causes, as recent CNN case of an advanced cancer pt who officially died of COVID, being fully vaccinated.

[Nick Myles @nmakrets]

@BareReality News from Canada: 'If you have not received your COVID-19 vaccine before Oct. 26, 2021, You will not be permitted to work, on-site or remotely; You will be placed on unpaid leave, and/or see a pause to your contract, education or on-site research You will not be able to use.etc"

[Nick Myles @nmakrets]

@dnunan79 YES The test should resolve or shift diagnostic uncertainty. No uncertainty=no tests. We are now in a muddy world of screening ..for risk factors. Tests for risk, risks for tests? We are facing a self-reference loop fallacy, mathematicians say.

[Carl Heneghan @carlheneghan]

Deaths in Britain above average for sixth week running https://t.co/gWbbif0War

[Nick Myles @nmakrets]

@carlheneghan @CebmOxford What an anomalous notch between Dec2020 and Jan21

[Nick Myles @nmakrets]

@MaxCRoser @guardian Fear and controversies sell the news, and fuel revolts if dominate

[Nick Myles @nmakrets]

@carlheneghan Any thoughts on "gain of function " experiments? Ethical? https://t.co/TT6TqeE4kp

[Nick Myles @nmakrets]

@mypathologistmd @berthagarcia5 @virchow @sholzberg @VirginiaWalley Absolutely overdue..many recent problems stemmed from a lack of understanding of medical testing process as a whole and over-reliance on expectation of "perfect test performance (unknown to medicine)".

[Nick Myles @nmakrets]

@bullox_ovea Нашелся!