Ben Lorenz, MD

infectious disease physician | hospitalist | asst prof |🏃🏾‍♂️📸🔭🚀🥾| opinions are my own

[Ben Lorenz, MD @noblerzen]

Grateful 🤲🏽

[Ben Lorenz, MD @noblerzen]

@PoPville Thanks for the heads up! We saw/smelled it! 👃🏽

[Ben Lorenz, MD @noblerzen]

@ABsteward @didwania1 @BradSpellberg @DrToddLee @Josh_S_Davis @syctong This was prior to Kefauver-Harris so essentially just in vitro activity and open-label studies https://t.co/XfL8LalDKI

[Ben Lorenz, MD @noblerzen]

@catherineeberry @LacuscHospMed @ABsteward Not much was provided in the protocol (Supplement 1, page 3, line 89): “The pre-specified non-inferiority margin was established somewhat arbitrarily because little clinical information was available to make a better estimate.”

[Ben Lorenz, MD @noblerzen]

@LacuscHospMed @ABsteward Usually an NI margin is based on historical evidence of treatment effect (eg. a placebo controlled trial), and there may be an allowance for what’s considered clinically acceptable. Here, the margin was made arbitrarily because of the lack of prior estimates.

[Ben Lorenz, MD @noblerzen]

@LacuscHospMed @ABsteward The pre-specified testing for non-inferiority used 1-sided testing and non-inferiority would have been met if the lower bound of the difference of the point estimates exceeded the lower limit of −6%. The lower bound of the 95% CI was −9.7%.

[Ben Lorenz, MD @noblerzen]

@naima

[Ben Lorenz, MD @noblerzen]

@_cingraham Totally not a geologist, but gonna guess rhyolite. Erosion from the water probably carved and smoothed out the vugs (where gas bubbles used to be).

[Ben Lorenz, MD @noblerzen]

@panda_worries @AshleyGWinter ... or just "cleanse" your wallet! 😳

[Ben Lorenz, MD @noblerzen]

@ENirenberg Since heart is no longer in situ, probably not 😕, but if this is T. solium, rupture or anti-helminthic Rx of active cysts can cause an inflammatory response (not good in anatomically sensitive organs like brain or eye)... These look calcified, so probably not viable.

[Ben Lorenz, MD @noblerzen]

@ELHopkins Yes, staying tuned for a more consistent case definition. Adenovirus type 41 is being considered, but recent prior COVID-19 (and perhaps MIS-C) could be a potential contributing factor.

[Ben Lorenz, MD @noblerzen]

@TheLakshmiK

[Ben Lorenz, MD @noblerzen]

@noraneus @JohnBerman @NewDay Glad he's back and feeling better! ... 🤣 at his pronunciation "rhabdomyolysis"

[Ben Lorenz, MD @noblerzen]

@MarcoSalvitti @NSFVoyager2 @p_finocchiaro @IoNonFaccioNien @Giulio_Firenze Earth is now moving in orbit in the direction of Voyager, which is faster than Voyager is moving from us.

[Ben Lorenz, MD @noblerzen]

@EbonyJHilton_MD We already have evidence of an incr risk of cardiovascular/thrombotic events, erectile dysfunction, diabetes, neurocognitive and autoimmune disorders. This isn't just a respiratory pathogen: it binds to ACE2 in blood vessels, intestines, kidney, testes, pancreas, heart, brain...

[Ben Lorenz, MD @noblerzen]

@Ethnography911 I think the strawberries and blueberries were fresh though. Definitely worth the trek! (I just randomly remembered that I drove the shuttle too)

[Ben Lorenz, MD @noblerzen]

@Ethnography911 Ivy Room had to lose money on those smoothies

[Ben Lorenz, MD @noblerzen]

@boulware_dr More than anything it's a test of endurance.

[Ben Lorenz, MD @noblerzen]

@krupali @darth Is that the talking device from Up on his collar?!

[Ben Lorenz, MD @noblerzen]

@ReignOfApril 😬... I coulda swore it was Ren & Stimpy tho!

[Ben Lorenz, MD @noblerzen]

@ReignOfApril I ruined it for myself too