@catherineeberry @LacuscHospMed @ABsteward Not much was provided in the protocol (Supplement 1, page 3, line 89): βThe pre-specified non-inferiority margin was established somewhat arbitrarily because little clinical information was available to make a better estimate.β
@LacuscHospMed @ABsteward Usually an NI margin is based on historical evidence of treatment effect (eg. a placebo controlled trial), and there may be an allowance for whatβs considered clinically acceptable. Here, the margin was made arbitrarily because of the lack of prior estimates.
@LacuscHospMed @ABsteward The pre-specified testing for non-inferiority used 1-sided testing and non-inferiority would have been met if the lower bound of the difference of the point estimates exceeded the lower limit of β6%. The lower bound of the 95% CI was β9.7%.
@_cingraham Totally not a geologist, but gonna guess rhyolite. Erosion from the water probably carved and smoothed out the vugs (where gas bubbles used to be).
@ENirenberg Since heart is no longer in situ, probably not π, but if this is T. solium, rupture or anti-helminthic Rx of active cysts can cause an inflammatory response (not good in anatomically sensitive organs like brain or eye)... These look calcified, so probably not viable.
@ELHopkins Yes, staying tuned for a more consistent case definition. Adenovirus type 41 is being considered, but recent prior COVID-19 (and perhaps MIS-C) could be a potential contributing factor.
@EbonyJHilton_MD We already have evidence of an incr risk of cardiovascular/thrombotic events, erectile dysfunction, diabetes, neurocognitive and autoimmune disorders. This isn't just a respiratory pathogen: it binds to ACE2 in blood vessels, intestines, kidney, testes, pancreas, heart, brain...
@Ethnography911 I think the strawberries and blueberries were fresh though. Definitely worth the trek! (I just randomly remembered that I drove the shuttle too)