NormalHumanBeing

nothing i say is serious unless you agree with it

[MonikaCinnyRoll 💫 3D Creator @MonikaCinnyRoll]

This will either be the funniest Game Awards or it will be the ending to "The Menu".
There's no in between.

[colette @iri_tonkotsu]

in my america youd be able to by loli rape doujins at bookstores. land of the free my ass

[NormalHumanBeing @normal_doing]

a couple screenshots, which have slight spoilers and are slightly boring since its just blocks. but i mainly want to show how beautiful the environments are

[NormalHumanBeing @normal_doing]

i got to the "big twist" of order of the sinking star after 65 hours and yeah its game of the year and definitely in top 10 games of all time

[NormalHumanBeing @normal_doing]

wildwood was a super pretty movie but it had horrible and boring writing, still like a 9/10 from the visuals alone but its painful to hear the characters talk at times

[Shvya @Sunderguilt]

One of my favorites that I painted this year

[わにやま @wani428]

えのじゅん

[わにやま @wani428]

スチームパンク赤松さんかわいい

[NormalHumanBeing @normal_doing]

my theory is that hes talking about all of this to make it appealing to investors because the company is getting sold off soon

[Tim Sweeney @TimSweeneyEpic]

We have a huge pivot underway here at Epic, moving developers around to retool for maximum AI acceleration.

The aim isn't to do the same stuff with fewer people, but to enable everyone here to build MORE and BETTER stuff, and to bring the benefits to all teams using Unreal.

[NormalHumanBeing @normal_doing]

theranos 2

[Citrini @citrini]

There’s a really pronounced divide between people who are on the AI side of things and people who are on the biology side of things. Even among people working in AI, the divide persists based on where they’re focused.

The AI side, adherents of scaling laws and the bitter lesson, believe that AI getting better means AI being more capable of novel discoveries in medicine (that go beyond discovering new drugs in well understood targets or speeding up dry lab work etc).

The biology people think the idea of a bitter lesson in biology is kind of ridiculous and that regardless of AI’s capabilities it’s going to be at least 5-10 years until you could hope to reliably simulate human toxicology in silico (right now AI/ML can’t even reliably simulate in vivo studies like binding affinities or functional assays).

Even the most AI pilled of them, who will list all the areas that AI can reduce the time spent on various areas, don’t think the concept of AI discovering novel targets or generating new understanding of causal biology is realistic in the near term. Most, in fact, will readily characterize the assumption that even an “ASI” level model could find cures hidden in our current understanding (without expanding that understanding with significantly more biological data) as patently false.

This was a big part of why we wanted to experience it ourselves by using AI for a (very) small portion of what it can do in biology. It was both mind blowing and revealed some poignant insights into how different the problem of making AI better at something like coding is to the problems of biology.

Even if it unlocked the ability to generate new molecules at a stunning pace, its simulation (in silico) of binding only had 49% accuracy. And if we wanted to improve that, we’d need to feed it back the data from the lab - data that took about 30x as long to get as it took to generate the molecules. And these were tests in a test tube (turn of phrase), imagine how long it would take if we wanted to improve the model with data that required recruiting humans and monitoring their reactions.

Human biology is very complex, and adding a drug - especially a novel drug and doubly so for a novel drug acting on a novel mechanism - means mapping interactions that have nth-order-effects that we don’t have the data to predict. Virtual cells have made advancements enabled by AI, but the perturbations equate to a small fraction of the possible.

This is before you even get into curing disease, especially uniquely human diseases. Brain function involves cellular identities that are unique to humans, meaning animal studies are of little use.

How long does it take to understand what the side effects of chronic administration of a drug in humans are? AI can speed up analyzing the data, or designing the trial or even getting it approved…but it can’t make a 6 month trial complete in 3 months.

I think its important to point out that significant advancements can be made in AI that contribute to biology, while also being realistic about how much it speeds up something as complex as curing a specific cancer or diseases of the brain.

[NormalHumanBeing @normal_doing]

all this talk when really what it boils down to is that the hades art style is fucking ugly so of course you dont find the characters depicted in an ugly art style to be visually appealing

[Lex Maniac 🦌🎃 @Lexbianism]

"Hades characters aren't hot" chuds are not attracted to women dawg you cannot tell me this isn't the hottest woman in fiction

[OscarJ QuinteroM @OscarjQuint2892]

Draconia Malfoy #HarryPotter #Malfoid #DraconiaMalfoy

[NormalHumanBeing @normal_doing]

order of the sinking star is fantastic so far

[NormalHumanBeing @normal_doing]

the very very start of the game is this then it gets insane

[Shivers @thinkingshivers]

I didn't realize that Order of the Sinking Star licensed a bunch of other Sokoban games.

Here's a level from Alan Hazelden's 2015 game "Skipping Stones to Lonely Homes" and its reproduction in Order of the Sinking Star.

[NormalHumanBeing @normal_doing]

are you fucking insane?? cincinnati is more of a shithole than detroit. same thing for houston. and chicago should be at the very bottom not slightly above LA

[Alessandro Palombo @thealepalombo]

America’s most livable cities, at local median salary and local tax rate.

New York: this is probably the reason why Mamdani won

[NormalHumanBeing @normal_doing]

in all the reasonable ones ive seen of this florida is a hellscape where half the year is miserable, which is accurate

[Penguin Wrangler @PenWrangler]

Look at what happens when you’re not a pussy and can enjoy what is given to you.

[Nico Niikura @niconiikura]

"Wanna go fishing?"

[NormalHumanBeing @normal_doing]

@HedgeDirty this is really stupid to say so confidently, i suggest leaving your house and not using twitter for a few months