Nicolò Tampellini

PhD student @MillerGroupYale 🇺🇸
B. Sc. @LabSynthesis 🇮🇹
Asymmetric catalysis with flasks and computers ⚗️💻

[Nicolò Tampellini @ntampellini_]

It's finally time to share this: my long time obsession with inherently chiral medium-sized rings now has a catalytic, enantioselective method. After a number of attempts, we developed a strategy based on choosing the maximally preorganized disconnection, which... [1/3]

[Nicolò Tampellini @ntampellini_]

Please check out Rowan, an amazing company taking the technical hassle out of computational chemistry!

The project is of course fully open source. Happy to see this project being adopted!

Code on Github: https://t.co/K5O8uCVPXi

4/4

[Nicolò Tampellini @ntampellini_]

Too many chemically identical rotamers in your CREST ensembles? If you are not interested in them, they can inflate your ensembles greatly!

https://t.co/Cj6n5Szc4n

(w/@RowanSci)

🧵1/4

[Nicolò Tampellini @ntampellini_]

In collaboration with Jonathon from @RowanSci, I packaged my code into a polished standalone library for ease of use and contribution! Working with Jonathon was not only a breeze, but also a great formative experience about modern software development practices (thanks!).

3/4

[kazuhiro morisaki @KmorisakiC]

Simple yet Efficient New Method for Direct Site-selective Deoxygenation of Benzylalcohol Derivatives is now out in @ChemRxiv (https://t.co/WpSuYT2iZ4)

[Baran Lab @BaranLabReads]

🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv (https://t.co/zGZFCsK7aK) the first method for stereoretentive radical cross-coupling is disclosed. No fancy ligands or redox needed—just a Ni-diazene twist. 120 years after Gomberg, a new chapter begins.

Quick summary:
Since Gomberg discovered free radicals over 120 years ago and Kochi pioneered radical cross-coupling in the 1970s, this field has surged with interest for linking C(sp3) fragments. Unlike traditional polar methods (e.g., Suzuki), radical cross-coupling excels with saturated systems, offering mild conditions and chemoselectivity to build complex molecules from common fragments. Until now, enantiospecific radical cross-coupling was deemed impossible due to rapid racemization, but today that changes with readily available sulfonylhydrazides and a simple Ni-catalyst. This stereoretentive approach, enabled by a unique Ni-diazene transition state and driven by loss of N2, skips chiral ligands and redox steps, opening new possibilities for synthesis.

[Angewandte Chemie @angew_chem]

Cationic, Iodine(III)-Mediated and Directed Diastereoselective Oxidation of Inert C-H Bonds in Cyclic Hydrocarbons (Nuno Maulide and co-workers) @MaulideLab #openaccess 🔓 https://t.co/4vjRTLFW2U

[Synthesis Workshop @MatthewHorwitz1]

Join us today as @ntampellini_ from @MillerGroupYale shares his work on enantiocontrolled cyclization reactions!! Thanks to Sourav @CompoSciTian_SM for hosting!

Link: https://t.co/1cQ0Tx3kmr

@J_A_C_S https://t.co/j0GMfh9RZ4

[Nicolò Tampellini @ntampellini_]

@andrea_rogolino @J_A_C_S Grazie Rogo 🤗

[Nicolò Tampellini @ntampellini_]

The final version of this work is now out in @J_A_C_S
https://t.co/fe98vGkbwy

[Nicolò Tampellini @ntampellini_]

It's finally time to share this: my long time obsession with inherently chiral medium-sized rings now has a catalytic, enantioselective method. After a number of attempts, we developed a strategy based on choosing the maximally preorganized disconnection, which... [1/3]

[Nicolò Tampellini @ntampellini_]

@therealprofhudd Very glad you do! 🤘🏻

[Nicolò Tampellini @ntampellini_]

@filippo_romiti @J_A_C_S Grazie Filo! 🙏🏻

[Nicolò Tampellini @ntampellini_]

@tymcdon @J_A_C_S Thanks a lot Tyler.
A warm praise in this format
Is of the best kind.

[Nicolò Tampellini @ntampellini_]

@AriWagen @RowanSci Great job! Looks crisp as always!

[Nicolò Tampellini @ntampellini_]

@CorinWagen I feel you - I had to write a Python parser for .cube files years ago and I was shocked to learn how they are put together 😅

[Nicolò Tampellini @ntampellini_]

Let's follow each other on Bluesky:
https://t.co/iqQj75ae5e

[Nicolò Tampellini @ntampellini_]

@KmorisakiC @ChemRxiv Awesome! Thank you, looking forward to reading about the next steps.

[kazuhiro morisaki @KmorisakiC]

Conceptually new asymmetric transformation—Reflexive Chirality Transfer (RCT)— appeared in @ChemRxiv (https://t.co/LNFljXeLSO).
1,3-Dipolar cycloaddition of amino acid Schiff bases proceeds with "preserving chirality" despite the once loss of the chirality at the α-carbon.

[Nicolò Tampellini @ntampellini_]

@LabSynthesis @ACSCatalysis Congrats @Giovanni_Cent11 @a_pellegrini15 @ChiaraPortolani! Enjoyed reading through the rigorous, comprehensive dissection of the mechanistic aspects. Great job!