Sepsis-associated AKI (SA-AKI): Pathophysiology
#Nephpearls#AKIinICU
📌 Organ dysfunction during sepsis develops even in the absence of decreased O2 delivery (Hypotension and ischemic injury are not the sole cause)
⚠️ Other mechanisms include microvascular dysfunction, endothelial injury, alterations of cellular metabolism, and immune system dysregulation
⚠️ Variations in renal microcirculation, diffusion
limitation from edema and inflammation, production of reactive oxygen species, and damage to the endothelial barrier and glycocalyx likely contribute to the structural and functional changes
⚠️ Sepsis treatment related factors, such as exposure to nephrotoxic drugs and hyperchloremia, can also indirectly contribute
👉 https://t.co/MYgINCCbZ6