Diazepam may not be effective for reducing the symptom burden for sciatica. A more appropriate treatment may be an NSAID such as naproxen or indometacin.
To reduce muscle spasms, Diazepam does not act directly on muscle tissue. Rather, it acts indirectly through its interactions with the GABA receptors within the brain & spinal cord.
Combining citalopram with amitriptyline is not recommended.
They compete for - amongst others - the same liver enzyme for their metabolism.
This can result in an increased concentration of one of the medications in the blood, increasing the risk of unwanted side effects
When considering between Ibuprofen + Naproxen, although similar in their efficacy. Ibuprofen has been shown to reduce pain quicker than Naproxen, whereas Naproxen has been shown to reduce pain over a longer period of time.
Alcohol🍺 is an absolute contraindication if you are also taking Amitriptyline.
It can causes heart rhythm abnormalities, hypotension + enhanced sedation ❌
Amitriptyline, a tricyclic antidepressant medication, is indicated for reducing nerve pain ✅
But, an unwanted side effect can be drowsiness. This effect is thought to be more pronounced in the elderly.
#nervepain#neuropathic#amitriptyline#sideeffects
Tramadol is a opioid medication indicated to manage severe pain
It may also help if you are suffering with neuropathic pain. Initial dose: 50mg every 4 hours. ✔️
#Tramadol#nervepain#opioid
Avoid drinking alcohol 🍺, if you're taking these medications 👇
▶️ Opioids e.g codeine
▶️ Benzodiazepines e.g. diazepam
▶️ Z Drugs e.g. zolpidem
#pain#benzos#zdrusg
If you have muscle spasms, and are concerned around the risk of dependence of controlled medications such as diazepam, methocarbamol is a viable alternative.
It’s less sedating and carries less risk of dependence ✅
#diazepam#benzos#methocarbamol#musclespasms
Baclofen - a medication indicated to reduce muscle spasms + spasticity associated with multiple sclerosis.
It’s contraindicated if you have stomach ulcers ❌
#MS#baclofen#musclespasms#pain
When comparing dihydrocodeine + codeine, both of which are opioid medications.
Dihydrocodeine is considered more effective at reducing pain ✅
#codeine#dihydrocodeine#pain#opioids
Prednisolone can have a severe interaction with these medications 👇
✅ Anti-coagulants e.g warfarin as it can either enhance or alter warfarin’s effect
✅ Live vaccines e.g MMR; prednisolone suppresses the immune system increasing risk of infection
#corticosteroid#pred