April Lo

Computational Biologist @AdaptiveBiotech | Ph.D. with @aliceb_phd @fredhutch & @uwgenome 🇭🇰 she/her

[April Lo @pamyl]

It's my #Twitterversary! I have been on Twitter for 14 years, since 22 Jan 2009 (via @twi_age).

[April Lo @pamyl]

Look it’s @mrvollger ! ❤️

[Alex Cagan @ATJCagan]

Mitchell Vollger on comprehensive diploid genetic and epigenetic profiles with single-molecule precision #AGBT23

[Mitchell R. Vollger @mrvollger]

We have a new family member! Bowie!!

He is very smart but, I am struggling to find training videos to get him interested in long reads and genome assembly. Please help!

[Dimitra Technology @dimltratech]

There are so many really incredible people in academia who get really harmed & burnt out from it. For all the kind and passionate people in academia who may be struggling, just know that many of us are grateful you're here, it's not YOU it's the system, and you're doing amazing.

[April Lo @pamyl]

finishing grad school with a cohort you love is so bittersweet because I am so so so proud of everyone but now that WE DID IT we're all going our separate ways and I'll miss everybody 🥺

[April Lo @pamyl]

@FutureDrDukes I felt similarly last week when I defended! I had a playlist titled "You Got This". took deep breaths. and the best advice I got is you're nervous bc you care a lot, it makes sense! and there's a thin line between nerves and excitement, this is normal :) good luck and have fun!

[April Lo @pamyl]

Thank you Alice!! That Dr. part is still sinking in but I know I'm so grateful for and proud of the lab and all we've done 💜💙

[Alice Berger @aliceb_phd]

Thrilled to congratulate @pamyl (Dr. April Lo) on a beautifully presented thesis defense yesterday! You can check out her work here https://t.co/9CjChtvouK and here: https://t.co/mFeOf5Duup

[Caitlin Pozmanter @CaiPoz]

Hey science Twitter! I’m teaching a class to introduce undergrads to reading biology literature in the fall. I’d like have some PIs/ authors do an interview the author with the class! Please retweet!

[Anna Minkina @Anna_Minkina]

I am delighted to share THE LORAX, a method which combines cell lineage trees (get it? 😉), scRNA-seq, & scATAC-seq to explore the underpinnings of clonal cell heterogeneity! (1/12)
https://t.co/1tFqLNzJ5w

[Michael Love @mikelove]

Got an RNA-seq dataset with 50, 100, 200+ samples? Plug it into a differential expression tool and hope for the best? No! You need to consider QC, EDA, and modeling technical variation, or else risk generating spurious results. A thread on papers, methods, and best practices:

[April Lo @pamyl]

@mglerner @IBJIYONGI I found and read this because of a book club with @UW_GSAIMS who might have some advice!

(I wasn't an organizer but led one discussion session and loved it, so I'd personally just say to all involved don't be shy! the discussions which spring from this writing are all valuable)

[April Lo @pamyl]

In one week, for one fun evening, you can hear me and my fellow scientists talk about why we study what we study!

If you're not yet convinced, here's a teaser in emojis for my pitch:
💀🚭🧐🧬🛩️💊

[Engage Science @EngageScience]

Join us for Pitch Night on March 8th! Each student will give and elevator pitch to sell you on their science, and in the end you'll vote for the funniest, most moving, and crowd favorite.

[Elevator not required]

https://t.co/IfADK60fya

[April Lo @pamyl]

It's my #Twitterversary! I have been on Twitter for 13 years, since 22 Jan 2009 (via @twi_age).

[Science Signaling @scisignal]

Lo (@pamyl), Berger (@aliceb_phd), and co show that the RIT1 member of the #RasProtein family induces cancer-linked changes in lung epithelial cells, both when mutated and overexpressed in wild-type form. @fredhutch #Biochemistry https://t.co/ILiFgMFcl2

[April Lo @pamyl]

@noncanonikyle @scisignal @aliceb_phd @skamlapurkar30 @sitapriya17 Thanks Kyle! 😄

[April Lo @pamyl]

I am SO excited and proud to present my first 1st author paper which characterizes RIT1, out today in @scisignal!

Big thank you’s to @aliceb_phd for being the best mentor, and my co-authors Kristin, @skamlapurkar30, Fil, @sitapriya17, and more 😊 1/🧵

https://t.co/XYN6J7JYcH

[April Lo @pamyl]

Overall, we provide transcriptomic, proteomic, and phosphoproteomic profiles of RIT1 and hope this resource helps to further studies of RIT1 to understand its role in cell signaling, lung cancer, and other disorders! 5/

[April Lo @pamyl]

By gene set analyses, we found that RIT1 corresponds to an EMT phenotype which was also reflected in migration assays and increased activity of the EMT genes Snail and Slug. 4/