RAPIDIBD

Redesigning A faster Pathway to IBD Diagnosis
RAPID
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[RAPIDIBD @PANTSresearch]

PANTS - Maximising patient data and samples + fantastic collaboration

Recruitment March 2013- July 2016

PANTS - FACTS
👥 1600+ patients
🩺13900 patient visits
🏥118 NHS Hospitals
👩‍💻300 NHS research staff
🧪~90000 frozen samples
💩~6000 poo samples
@tariqahmadIBD

[National Institute for Health and Care Research @NIHRresearch]

Free e-learning resources are available for health and care researchers to help develop your leadership skills. Log in or register on NIHR Learn and select Leadership Development and then Leadership e-learning modules to find out more: https://t.co/jyhnh0CLyd

[RAPIDIBD @PANTSresearch]

No10 !! 3 YR
Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study -https://t.co/hQwMjWOkhT

@ibdseb @charlie_lees @exeteribdresea1
Watch this space

[RAPIDIBD @PANTSresearch]

PANTS - Maximising patient data and samples + fantastic collaboration

Recruitment March 2013- July 2016

PANTS - FACTS
👥 1600+ patients
🩺13900 patient visits
🏥118 NHS Hospitals
👩‍💻300 NHS research staff
🧪~90000 frozen samples
💩~6000 poo samples
@tariqahmadIBD

[RAPIDIBD @PANTSresearch]

No9
Baseline TREM-1 Whole Blood Gene Expression Does Not Predict Response to Adalimumab Treatment in Patients with Ulcerative Colitis or Crohn’s Disease in the SERENE Studies https://t.co/yNIxlvPTUI
@SeverineVermei1 @bverstockt

[CLARITY IBD @clarityibd]

Week 2 @NIHRresearch.

✅84 🏥 in set up.
✅30 🏥 ready to 🟢!
✅52 patients recruited.
✅ 3500 patient packs sent.

Active #IBDresearch collaborations in 🏴󠁧󠁢󠁷󠁬󠁳󠁿 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🏴󠁧󠁢󠁥󠁮󠁧󠁿

[RAPIDIBD @PANTSresearch]

Eight years later, the pub’s still the best place for PANTS ideas. Watch this space...

[Edward Loftus @EdwardLoftus2]

Genetic variant influences anti-TNF immunogenicity in Crohn’s https://t.co/G2GZwjqxkt HLA-DQA1*05 essentially doubles the rate of immunogenicity @HealioGastro @AGA_Gastro

[Eric Topol @EricTopol]

The main treatment for #Crohns disease is a TNF-antibody, but many patients develop an immune response. It turns out that a common HLA allele (40% w/ European ancestry) is tied to this problem https://t.co/HlAMUZEGnB @AGA_Gastro @AmerGastroAssn #PGX

[Nick Kennedy @DrNickKennedy]

Our #GWAS of immunogenicity to anti-TNF in #Crohns has just gone online at @AGA_Gastro. Thanks to all the patients, PIs, nurses and the hard work of the @PANTSresearch team led by @tariqahmadIBD and @anderson_carl's group at @sangerinstitute! https://t.co/EbzGUKWU1z

[Charlie Lees @charlie_lees]

This is @PANTSresearch - collaborative UK IBD research at its best. Led tirelessly by @tariqahmadIBD + @ClaireBewshea ... driven by @DrNickKennedy + @alehins ... & many of us with brilliant sites & >1500 patients, prospective data and a gene hit of direct clinical utility.

[Charlie Lees @charlie_lees]

BRAVO @PRED4research Tariq & @ClaireBewshea - Not only transforming the pharmacogenetic landscape in #IBD, but also launching a vintage era for IBD research in the UK - collaborative, #bigdata projects - demonstrating what is possible with vision & grit on a shoestring.

[PRED4 @PRED4research]

3000 patients 👩‍👩‍👦, 7 years 🗓️, 9 arms 🧬, 162 sites 🏥 later... thank you to all the patients, research nurses and PIs who have contributed to @pred4research....