26年5月發佈在期刊(Cell Metabolism)上的研究:
大蒜裏面的S1PC能延緩衰老,前提是有脂肪
Summary
Garlic (Allium sativum L.) and its aged extract contain many bioactive compounds that can bring health benefits to humans. Among them, S-1-propenyl-L-cysteine (S1PC) has recently drawn significant attention in the field of nutriceutical research. However, the mechanism of its molecular action has remained poorly understood. Here, we show that S1PC significantly activates liver kinase B1 (LKB1) through enhancing its tertiary complex formation with STRAD and MO25, leading to stimulating the phosphorylation of a mammalian NAD+-dependent protein deacetylase, SIRT1, and promoting the secretion of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in white adipose tissue (WAT). Interestingly, eNAMPT secreted from WAT specifically targets the hypothalamus, significantly enhancing skeletal muscle force and improving frailty indices in aged mice. Furthermore, S1PC is also able to increase circulating eNAMPT levels in human individuals who maintain healthy adipose mass. These findings demonstrate that S1PC specifically stimulates the LKB1-SIRT1 pathway and enhances eNAMPT secretion in WAT, counteracting skeletal muscle aging in aged individuals.
source:https://t.co/U0aWNwLfeh
Siri sucks. So I made a way for Codex to act as my iPhone's voice assistant.
Now Codex can read my screen, control apps, and take actions on my behalf – all in vanilla iOS 27.
All right chat, it’s that time of the month again.
What’s your #1 highest conviction stock and why?
I actually learn a lot from reading these, so share some cool ideas.
✳️
Merger Date
New from The Information just now:
Cursor staff were told their merger deal could close as soon as the end of next week — around August 14. Elon already confirmed almost all regulatory hurdles are cleared and the close is “quite soon.” This is much earlier than the announced "end of Q3", which shows how things are imminent on all sides.
Let's be precise:
Nothing in the SpaceX-Cursor merger agreement prevents SpaceX from announcing a Tesla merger before the Cursor deal closes. Exclusivity is one-way only (it binds Cursor, not SpaceX), and Parent’s covenants are extremely narrow.
But: waiting until after Cursor closes is the cleanest path. It avoids any residual regulatory optics, gun-jumping questions, or appearance of conflict while the deal is still pending.
One important mechanic you should understand:
The Cursor deal is an all-stock transaction at a fixed $60 billion equity value. The exact number of SPCX shares Cursor shareholders receive is calculated using SpaceX’s volume-weighted average stock price over the 7 trading days immediately before the closing date (so already including Wed - Friday this week).
Announcing a Tesla merger while that 7-day pricing window is still open could inject massive volatility into SPCX stock and create unnecessary noise around the share calculation.
With Cursor locking in around the 14th, a Tesla merger announcement over the weekend of August 16 is now both my "cleanest and the highest-probability".